Patents by Inventor Constantin Polychronakos

Constantin Polychronakos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Genetic alterations on chromosome 16 and methods of use thereof for the diagnosis and treatment of type 1 diabetes

Patent number: 10266896

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Grant

Filed: September 14, 2016

Date of Patent: April 23, 2019

Assignee: The Children's Hospital of Philadelphia

Inventors: Hakon Hakonarson, Struan F. A. Grant, Jonathan P. Bradfield, Constantin Polychronakos
Genetic alterations on chromosomes 21Q, 6Q and 15Q and methods of use thereof for the diagnosis and treatment of type 1 diabetes

Patent number: 10066266

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Grant

Filed: February 20, 2015

Date of Patent: September 4, 2018

Assignee: The Children's Hospital of Philadelphia

Inventors: Hakon Hakonarson, Struan Frederick Airth Grant, Jonathan Paul Bradfield, Constantin Polychronakos, Hui-Qi Qu
Genetic alterations associated with type I diabetes and methods for use thereof for diagnosis and treatment

Patent number: 9926600

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Grant

Filed: April 14, 2014

Date of Patent: March 27, 2018

Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA

Inventors: Hakon Hakonarson, Joseph Glessner, Struan F. A. Grant, Constantin Polychronakos
Genetic Alterations on Chromosome 16 and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes

Publication number: 20170044611

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Application

Filed: September 14, 2016

Publication date: February 16, 2017

Inventors: Hakon Hakonarson, Struan F.A. Grant, Jonathan P. Bradfield, Constantin Polychronakos
Genetic Alterations on Chromosomes 21Q, 6Q and 15Q and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes

Publication number: 20150299793

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Application

Filed: February 20, 2015

Publication date: October 22, 2015

Inventors: Hakon Hakonarson, Struan F.A. Grant, Jonathan Bradfield, Constantin Polychronakos, Hui-Qi Qu
Genetic Alterations Associated with Type I Diabetes and Methods of Use Thereof for Diagnosis and Treatment

Publication number: 20150023984

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Application

Filed: April 14, 2014

Publication date: January 22, 2015

Applicant: The Children's Hospital of Philadelphia

Inventors: Hakon Hakonarson, Jonathan Bradfield, Struan Grant, Constantin Polychronakos
Genetic alterations on chromosome 12 and methods of use thereof for the diagnosis and treatment of type 1 diabetes

Patent number: 8575120

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Grant

Filed: March 13, 2008

Date of Patent: November 5, 2013

Assignee: The Children's Hospital of Philadelphia

Inventors: Hakon Hakonarson, Struan F. A. Grant, Jonathan P. Bradfield, Constantin Polychronakos
Genetic Alterations on Chromosome 12 and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes

Publication number: 20120095074

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Application

Filed: March 13, 2008

Publication date: April 19, 2012

Inventors: Hakon Hakonarson, Struan F.A. Grant, Jonathan P. Bradfield, Constantin Polychronakos
Genetic Alterations on Chromosome 16 and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes

Publication number: 20110286997

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Application

Filed: March 13, 2008

Publication date: November 24, 2011

Inventors: Hakon Hakonarson, Struan F.A. Grant, Jonathan P. Bradfield, Constantin Polychronakos
Genetic Alterations Associated with Type I Diabetes and Methods of Use Thereof for Diagnosis and Treatment

Publication number: 20110243922

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Application

Filed: October 8, 2009

Publication date: October 6, 2011

Inventors: Hakon Hakonarson, Struan F.A. Grant, Joseph Glessner, Constantin Polychronakos
Genetic Alterations on Chromosomes 21q, 6q and 15q and Methods of Use Thereof for the Diagnosis and Treatment of Type I Diabetes

Publication number: 20110236370

Abstract: Compositions and methods for the detection and treatment of T1D are provided.

Type: Application

Filed: November 16, 2010

Publication date: September 29, 2011

Inventors: Hakon Hakonarson, Struan Grant, Jonathan Bradfield, Constantin Polychronakos, Hui-Qi Qu
Continuous glucose quantification device and method

Publication number: 20040108226

Abstract: A device and method for glucose quantification in a liquid medium using a reference electrode; a counter electrode and a working electrode with a semipermeable membrane is provided.

Type: Application

Filed: October 28, 2003

Publication date: June 10, 2004

Inventors: Constantin Polychronakos, Marcus F. Lawrence, Olivier Leloup
DNA assay for the prediction of autoimmune diabetes

Patent number: 6534272

Abstract: The present invention relates to a novel DNA assay for the diagnosis and/or prediction of autoimmune diabetes. The present invention relates to a DNA assay for the prediction of autoimmune diabetes in human subjects, which comprises the steps of a) obtaining a DNA sample from the subject and amplifying at least one class III allele of variable number of tandem repeats (VNTR) located upstream of the insulin gene (INS) which is associated with silencing of thymic insulin mRNA expression; and b) subjecting the sample to electrophoresis to identify the silencing class III allele.

Type: Grant

Filed: July 23, 2001

Date of Patent: March 18, 2003

Assignee: McGill University

Inventors: Constantin Polychronakos, Petros Vafiadis, Rosemarie Grabs, Houria Ounissi-Benkalha
DNA assay for the prediction of autoimmune diabetes

Publication number: 20020160376

Abstract: The present invention relates to a novel DNA assay for the diagnosis and/or prediction of autoimmune diabetes. The present invention relates to a DNA assay for the prediction of autoimmune diabetes in human subjects, which comprises the steps of a) obtaining a DNA sample from the subject and amplifying at least one class III allele of variable number of tandem repeats (VNTR) located upstream of the insulin gene (INS) which is associated with silencing of thymic insulin mRNA expression; and b) subjecting the sample to electrophoresis to identify the silencing class III allele.

Type: Application

Filed: July 23, 2001

Publication date: October 31, 2002

Inventors: Constantin Polychronakos, Petros Vafiadis, Rosemarie Grabs, Houria Ounissi-Benkalha