Patents by Inventor CONSTANTINE CHRYSOSTOMOU

CONSTANTINE CHRYSOSTOMOU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HOMING ENDONUCLEASE VARIANTS
    Publication number: 20250368973
    Abstract: The present disclosure provides homing endonuclease variants and megaTALs reprogrammed to bind and cleave a polynucleotide sequence in the genome. The homing endonuclease variants and megaTALs have been engineered to increase the thermostability and/or activity.
    Type: Application
    Filed: August 19, 2025
    Publication date: December 4, 2025
    Applicant: Novo Nordisk A/S
    Inventors: Jordan JARJOUR, Kyle HAVENS, Constantine CHRYSOSTOMOU
  • Homing endonuclease variants
    Patent number: 12404500
    Abstract: The present disclosure provides homing endonuclease variants and megaTALs reprogrammed to bind and cleave a polynucleotide sequence in the genome. The homing endonuclease variants and megaTALs have been engineered to increase the thermostability and/or activity.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: September 2, 2025
    Assignee: NOVO NORDISK A/S
    Inventors: Jordan Jarjour, Kyle Havens, Constantine Chrysostomou
  • HOMING ENDONUCLEASE VARIANTS
    Publication number: 20220119784
    Abstract: The present disclosure provides homing endonuclease variants and megaTALs reprogrammed to bind and cleave a polynucleotide sequence in the genome. The homing endonuclease variants and megaTALs have been engineered to increase the thermostability and/or activity.
    Type: Application
    Filed: December 9, 2019
    Publication date: April 21, 2022
    Applicant: 2seventy bio, Inc.
    Inventors: JORDAN JARJOUR, KYLE HAVENS, CONSTANTINE CHRYSOSTOMOU