Patents by Inventor Constantine Mitsiades

Constantine Mitsiades has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THREE-DIMENSIONAL TISSUE STRUCTURES
    Publication number: 20200063108
    Abstract: The present invention provides methods of three dimensional tissue cultures and methods of using same.
    Type: Application
    Filed: February 28, 2018
    Publication date: February 27, 2020
    Inventors: Eugen DHIMOLEA, Constantine MITSIADES
  • Systems, apparatus, and methods related to magnetically-controlled three-dimensional tissue cultures
    Patent number: 10221381
    Abstract: Systems, devices, and methods for generating, culturing, and using magnetically-controlled three-dimensional (3D) tissues are described. A magnetically-enabled transwell system for immobilizing and supplying perfusion to a 3D mini-tissue includes a cell culture vessel with at least a first chamber and a second chamber, the mini-tissue being disposed in the first chamber, and a perfusion mechanism defining an elongate perfusion channel with a proximal end in the first chamber and a distal end in fluid communication with the second chamber, with a magnetic element configured to immobilize a magnetically-controlled 3D mini-tissue such that the proximal end is in fluid communication with basolateral space of the immobilized mini-tissue.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: March 5, 2019
    Assignee: Dana-Faber Cancer Institute, Inc.
    Inventors: Eugen Dhimolea, Constantine Mitsiades
  • SYSTEMS, APPARATUS, AND METHODS RELATED TO MAGNETICALLY-CONTROLLED THREE-DIMENSIONAL TISSUE CULTURES
    Publication number: 20170137766
    Abstract: Systems, devices, and methods for generating, culturing, and using magnetically-controlled three-dimensional (3D) tissues are described. A magnetically-enabled transwell system for immobilizing and supplying perfusion to a 3D mini-tissue includes a cell culture vessel with at least a first chamber and a second chamber, the mini-tissue being disposed in the first chamber, and a perfusion mechanism defining an elongate perfusion channel with a proximal end in the first chamber and a distal end in fluid communication with the second chamber, with a magnetic element configured to immobilize a magnetically-controlled 3D mini-tissue such that the proximal end is in fluid communication with basolateral space of the immobilized mini-tissue.
    Type: Application
    Filed: June 30, 2015
    Publication date: May 18, 2017
    Inventors: Eugen Dhimolea, Constantine Mitsiades
  • Aplidine for multiple myeloma treatment
    Publication number: 20070149445
    Abstract: Aplidine and aplidine analogues are used in the manufacture of a medicament for treating multiple myeloma.
    Type: Application
    Filed: March 12, 2004
    Publication date: June 28, 2007
    Inventors: Joseph Bertino, Daniel Medina, Glynn Faircloth, Constantine Mitsiades, Kenneth Anderson, Nicholas Mitsiades
  • Aplidine for multiple myeloma treatment
    Publication number: 20060172926
    Abstract: Aplidine and aplidine analogues are used in the manufacture of a medicament for treating multiple myeloma.
    Type: Application
    Filed: March 12, 2004
    Publication date: August 3, 2006
    Inventors: Joseph Bertino, Daniel Medina, Glynn Faircloth, Constantine Mitsiades, Kenneth Anderson, Nicholas Mitsiades
  • Methods and compositions for treating cancer using proteasome inhibitors
    Publication number: 20050267037
    Abstract: The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
    Type: Application
    Filed: April 29, 2005
    Publication date: December 1, 2005
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Kenneth Anderson, Teru Hideshima, Constantine Mitsiades, Nicholas Mitsiades