Patents by Inventor Cord Brakebusch

Cord Brakebusch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-p55 TNF receptor antibody
    Patent number: 7728111
    Abstract: A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: June 1, 2010
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Cord Brakebusch
  • TNF RECEPTOR ACTION MODULATION
    Publication number: 20090088558
    Abstract: A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.
    Type: Application
    Filed: August 12, 2008
    Publication date: April 2, 2009
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: David WALLACH, Cord Brakebusch
  • TNF receptor action modulation
    Patent number: 7429379
    Abstract: A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: September 30, 2008
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Cord Brakebusch
  • TNF receptor action modulaton
    Publication number: 20060210560
    Abstract: A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.
    Type: Application
    Filed: April 14, 2006
    Publication date: September 21, 2006
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Cord Brakebusch
  • TNF receptor action modulation
    Patent number: 7056505
    Abstract: A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: June 6, 2006
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Cord Brakebusch
  • TNF receptor action modulation
    Publication number: 20020142357
    Abstract: A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.
    Type: Application
    Filed: April 12, 2002
    Publication date: October 3, 2002
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Cord Brakebusch
  • TNF receptor action modulation
    Patent number: 6395267
    Abstract: A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.
    Type: Grant
    Filed: May 3, 1993
    Date of Patent: May 28, 2002
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Cord Brakebusch
  • Expression of the recombinant tumor necrosis factor binding protein I (TBP-I)
    Patent number: 5811261
    Abstract: Tumor Necrosis Factor Binding Protein I (TBP-I), precursors and analogs thereof, are produced by transfecting eukaryotic cells with an expression vector comprising al DNA molecule encoding the whole human type I TNF receptor or a soluble domain thereof, and culturing the transfected cells, whereby the soluble proteins are secreted into the medium.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: September 22, 1998
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Yaron Nophar, Oliver Kemper, Hartmut Engelmann, Cord Brakebusch, Dan Aderka
  • Method for identifying and producing a protease capable of cleaving the TNF receptor
    Patent number: 5766917
    Abstract: Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: June 16, 1998
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Cord Brakebusch, Eugene Varfolomeev, Michael Batkin
  • Molecules influencing the shedding of the TNF receptor, their preparation and their use
    Patent number: 5665859
    Abstract: Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: September 9, 1997
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Cord Brakebusch, Eugene Varfolomeev, Michael Batkin
  • Multimers of the soluble forms of TNF receptors, their preparation and pharmaceutical compositions containing them
    Patent number: 5478925
    Abstract: Multimers of the soluble forms of the tumor necrosis factor receptors (TNF-Rs) are provided. These multimers are produced either by chemical or by recombinant methods. The multimers of the soluble forms of TNF-Rs are useful for protecting mammals (including humans) from the deleterious effects of TNF.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: December 26, 1995
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Cord Brakebusch