Abstract: The present invention discloses polynucleotides which identify and encode pDP214 as well as novel functions for the DP214 gene family (pDP214) which are specifically expressed specifically expressed in the mesenchyme of the developing pancreas, in the lung, the stomach, the kidney and specific areas of the ectoderm such as ectodermal ridge and hair follicles. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding pDP214 and a method for producing pDP214. The invention also provide for agonists, antibodies, or antagonists specifically binding, pDP214, and their, use, in the prevention and treatment of diseases associated with the expression of pDP214. Additionally, the invention provides for the use or antisense molecules to polynucleotides encoding pDP214 for the treatment or diseases associated with the expression of pDP214.