Patents by Inventor Corey D. Braastad

Corey D. Braastad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS TO DETECT A SILENT CARRIER GENOTYPE
    Publication number: 20240018587
    Abstract: Provided herein are methods and compositions for the detection of silent carriers of chromosomal deletion alleles in a human subject using haploid cells (e.g., sperm cells or egg cells) derived from the subject. The methods provided herein allow for the detection of silent (2+0) carriers of SMA, where the individual has a deletion of the SMN1 gene on one chromosome 5 homolog and two or more copies of the SMN1 gene on the other chromosome 5 homolog.
    Type: Application
    Filed: September 6, 2023
    Publication date: January 18, 2024
    Applicant: Athena Diagnostics, Inc.
    Inventors: David A. Hill, Matthew Evans, Corey D. Braastad
  • Methods of detecting mutations associated with ataxia-ocular apraxia 2 (AOA2)
    Patent number: 11512352
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: November 29, 2022
    Assignee: Athena Diagnostics, Inc.
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan K. Allen, Sat Dev Batish, Hui Zhu
  • METHODS TO DETECT A SILENT CARRIER GENOTYPE
    Publication number: 20200385807
    Abstract: Provided herein are methods and compositions for the detection of silent carriers of chromosomal deletion alleles in a human subject using haploid cells (e.g., sperm cells or egg cells) derived from the subject. The methods provided herein allow for the detection of silent (2+0) carriers of SMA, where the individual has a deletion of the SMN1 gene on one chromosome 5 homolog and two or more copies of the SMN1 gene on the other chromosome 5 homolog.
    Type: Application
    Filed: June 24, 2020
    Publication date: December 10, 2020
    Applicant: Athena Diagnostics, Inc.
    Inventors: David A. Hill, Matthew Evans, Corey D. Braastad
  • Methods to detect a silent carrier genotype
    Patent number: 10697016
    Abstract: Provided herein are methods and compositions for the detection of silent carriers of chromosomal deletion alleles in a human subject using haploid cells (e.g., sperm cells or egg cells) derived from the subject. The methods provided herein allow for the detection of silent (2+0) carriers of SMA, where the individual has a deletion of the SMN1 gene on one chromosome 5 homolog and two or more copies of the SMN1 gene on the other chromosome 5 homolog.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: June 30, 2020
    Assignee: ATHENA DIAGNOSTICS, INC.
    Inventors: David A. Hill, Matthew Evans, Corey D. Braastad
  • METHODS OF DETECTING MUTATIONS ASSOCIATED WITH ATAXIA-OCULAR APRAXIA 2 (AOA2)
    Publication number: 20200149107
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Application
    Filed: August 20, 2019
    Publication date: May 14, 2020
    Applicant: Athena Diagnostics, Inc.
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan K. Allen, Sat Dev Batish, Hui Zhu
  • METHODS TO DETECT A SILENT CARRIER GENOTYPE
    Publication number: 20190300955
    Abstract: Provided herein are methods and compositions for the detection of silent carriers of chromosomal deletion alleles in a human subject using haploid cells (e.g., sperm cells or egg cells) derived from the subject. The methods provided herein allow for the detection of silent (2+0) carriers of SMA, where the individual has a deletion of the SMN1 gene on one chromosome 5 homolog and two or more copies of the SMN1 gene on the other chromosome 5 homolog.
    Type: Application
    Filed: February 25, 2019
    Publication date: October 3, 2019
    Applicant: Athena Diagnostics, Inc.
    Inventors: DAVID A. HILL, Matthew Evans, Corey D. Braastad
  • Methods to detect a silent carrier of a null allele genotype
    Patent number: 10227650
    Abstract: Provided herein are methods and compositions for the detection of silent carriers of chromosomal deletion alleles in a human subject using haploid cells (e.g., sperm cells or egg cells) derived from the subject. The methods provided herein comprise quantitative nucleic acid amplification reactions and determination of a ratio of a target gene to a reference gene, and indicate that a subject is a silent carrier of a null allele corresponding to the target gene if the ratio is at or below a threshold level. The methods provided herein allow for the detection of silent (2+0) carriers of SMA, where the individual has a deletion of the SMN1 gene on one chromosome 5 homolog and two or more copies of the SMN1 gene on other chromosome 5 homolog.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: March 12, 2019
    Assignee: Athena Diagnostics, Inc.
    Inventors: David A. Hill, Matthew Evans, Corey D. Braastad
  • METHODS OF DETECTING MUTATIONS ASSOCIATED WITH ATAXIA-OCULAR APRAXIA 2 (AOA2)
    Publication number: 20170166970
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Application
    Filed: February 21, 2017
    Publication date: June 15, 2017
    Applicant: Athena Diagnostics, Inc.
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan K. Allen, Sat Dev Batish, Hui Zhu
  • Methods of detecting mutations associated with ataxia-ocular apraxia 2 (AOA2)
    Patent number: 9611512
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: April 4, 2017
    Assignee: ATHENA DIAGNOSTICS, INC.
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan K. Allen, Sat Dev Batish, Hui Zhu
  • METHODS TO DETECT A SILENT CARRIER GENOTYPE
    Publication number: 20160153037
    Abstract: Provided herein are methods and compositions for the detection of silent carriers of chromosomal deletion alleles in a human subject using haploid cells (e.g., sperm cells or egg cells) derived from the subject. The methods provided herein allow for the detection of silent (2+0) carriers of SMA, where the individual has a deletion of the SMN1 gene on one chromosome 5 homolog and two or more copies of the SMN1 gene on the other chromosome 5 homolog.
    Type: Application
    Filed: November 13, 2015
    Publication date: June 2, 2016
    Applicant: ATHENA DIAGNOSTICS, INC.
    Inventors: David A. Hill, Matthew Evans, Corey D. Braastad
  • METHODS OF DETECTING MUTATIONS ASSOCIATED WITH ATAXIA-OCULAR APRAXIA 2 (AOA2)
    Publication number: 20140323318
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Application
    Filed: July 11, 2014
    Publication date: October 30, 2014
    Inventors: Corey D. BRAASTAD, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan K. Allen, Sat Dev Batish, Hui Zhu
  • Methods of detecting mutations associated with ataxia-ocular apraxia 2 (AOA2)
    Patent number: 8785122
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: July 22, 2014
    Assignee: Athena Diagnostics, Inc.
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan Allen, Sat Dev Batish, Hui Zhu
  • METHODS OF DETECTING MUTATIONS ASSOCIATED WITH ATAXIA-OCULAR APRAXIA 2 (AOA2)
    Publication number: 20120237934
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Application
    Filed: June 4, 2012
    Publication date: September 20, 2012
    Applicant: Athena Diagnostics, Inc.
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan Allen, Sat Dev Batish, Hui Zhu
  • Methods of detecting mutations associated with ataxia-ocular apraxia 2 (AOA2)
    Patent number: 8192933
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: June 5, 2012
    Assignee: Athena Diagnostics, Inc.
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan Allen, Sat Dev Batish, Hui Zhu
  • Methods of Detecting Mutations Associated With Ataxia-Ocular Apraxia 2 (AOA2)
    Publication number: 20100167305
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Application
    Filed: March 11, 2010
    Publication date: July 1, 2010
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan Allen, Sat Dev Batish, Hui Zhu
  • Methods of detecting mutations associated with ataxia-ocular apraxia 2 (AOA2)
    Patent number: 7704691
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: April 27, 2010
    Assignee: Athena Diagnostics, Inc.
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan Allen, Sat Dev Batish, Hui Zhu