Abstract: Device and method for handling biological specimens. For example, the device includes a base and a substrate. The substrate includes a first surface disposed on the base and a second surface configured to support a biological specimen. A compressive element is disposed on the second surface of the substrate and surrounds the biological specimen. The compressive element includes an opening opposite the second surface of the substrate on which the compressive element is placed. The opening is configured to form a well that allows one or more reagents to be introduced into the well for chemically processing the biological specimen. The compressive element and the base cooperate to secure the compressive element to the substrate to form a seal which is configured to retain the one or more reagents in the well.

Abstract: Method and system for processing biological specimens. For example, the method includes loading a plurality of biological specimens on a continuous substrate at a plurality of spaced-apart locations on the continuous substrate, attaching a plurality of wells to the continuous tape substrate corresponding to the plurality of spaced-apart locations where each well surrounds a respective biological specimen on the continuous substrate, performing one or more chemical processes on the respective biological specimen contained in the each well of the plurality of wells, and analyzing results of the one or more chemical processes on the respective biological specimen contained in the each well of the plurality of wells.