Patents by Inventor Corey S. Goodman
Corey S. Goodman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100233819Abstract: Robo1 and Robo2 polypeptides may be produced recombinantly from transformed host cells from the disclosed Robo encoding nucleic acids or purified from human cells. The invention provides isolated Robo hybridization probes and primers capable of specifically hybridizing with the disclosed Robo genes, Robo-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: ApplicationFiled: March 10, 2009Publication date: September 16, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: COREY S. GOODMAN, THOMAS KIDD, KEVIN J. MITCHELL, GUY TEAR
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Publication number: 20090155928Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides.Type: ApplicationFiled: August 13, 2007Publication date: June 18, 2009Applicant: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
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Publication number: 20080312158Abstract: A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.Type: ApplicationFiled: June 14, 2007Publication date: December 18, 2008Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Corey S. Goodman, Alex L. Kolodkin, David Matthes, David R. Bentley, Timothy O'Connor
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Patent number: 7153936Abstract: A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.Type: GrantFiled: February 4, 2002Date of Patent: December 26, 2006Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Alex L. Kolodkin, David Matthes, David R. Bentley, Timothy O'Connor
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Patent number: 7005411Abstract: The amount of active Robo expressed on a cell is modified by modulating the effective amount of a Comm polypeptide in contact with the cell, whereby the amount of expressed active Robo is modulated inversely with the modulation of the effective amount of the Comm polypeptide in contact with the cell. In a particular embodiment, the Comm polypeptide is provided to the cell by exogenously in a pharmaceutically acceptable composition. In another aspect, the invention provides methods of screening for agents which modulate Robo-Comm interactions. These methods generally involve forming a mixture of a Robo-expressing cell, a Comm polypeptide and a candidate agent, and determining the effect of the agent on the amount of Robo expressed by the cell.Type: GrantFiled: November 13, 1998Date of Patent: February 28, 2006Assignee: Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Guy Tear, Claire Russell, Kevin J. Mitchell
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Patent number: 6861228Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides.Type: GrantFiled: November 6, 2002Date of Patent: March 1, 2005Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
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Publication number: 20040167226Abstract: Methods are disclosed for treating and preventing pain such as neuropathic pain, and traumatic injuries such as traumatic brain injury and acute spinal cord injury, which comprise administering effective amounts of a benzamide compound of formula I: 1Type: ApplicationFiled: December 15, 2003Publication date: August 26, 2004Inventors: Tito A. Serafini, Corey S. Goodman
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Publication number: 20030170727Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides.Type: ApplicationFiled: November 6, 2002Publication date: September 11, 2003Inventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
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Publication number: 20030166849Abstract: A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.Type: ApplicationFiled: February 4, 2002Publication date: September 4, 2003Inventors: Corey S. Goodman, Alex L. Kolodkin, David Matthes, David R. Bentley, Timothy O'Connor
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Patent number: 6344544Abstract: A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.Type: GrantFiled: April 15, 1998Date of Patent: February 5, 2002Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Alex L. Kolodkin, David Matthes, David R. Bentley, Timothy O'Connor
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Patent number: 6270984Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the agent modulates the interaction of the Robo and Slit polypeptides.Type: GrantFiled: March 31, 2000Date of Patent: August 7, 2001Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
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Patent number: 6270995Abstract: Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides.Type: GrantFiled: March 31, 2000Date of Patent: August 7, 2001Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
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Patent number: 6046015Abstract: Disclosed are methods and compositions for identifing agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the agent modulates the interaction of the Robo and Slit polypeptides.Type: GrantFiled: November 13, 1998Date of Patent: April 4, 2000Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Thomas Kidd, Katja Brose, Marc Tessier-Lavigne
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Patent number: 6013781Abstract: A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.Type: GrantFiled: April 8, 1997Date of Patent: January 11, 2000Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Alex L. Kolodkin, David Matthes, David R. Bentley, Timothy O'Connor
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Patent number: 5935865Abstract: A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.Type: GrantFiled: April 15, 1998Date of Patent: August 10, 1999Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Alex L. Kolodkin, David Matthes, David R. Bentley, Timothy O'Connor
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Patent number: 5807826Abstract: A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.Type: GrantFiled: April 8, 1997Date of Patent: September 15, 1998Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Alex L. Kolodkin, David Matthes, David R. Bentley, Timothy O'Connor
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Patent number: 5639856Abstract: A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.Type: GrantFiled: September 13, 1993Date of Patent: June 17, 1997Assignee: The Regents of the University of CaliforniaInventors: Corey S. Goodman, Alex L. Kolodkin, David Matthes, David R. Bentley, Timothy O'Connor