Patents by Inventor Corina GABAZZA

Corina GABAZZA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic mouse expressing kidney-specific human TGF-beta1, and biomarker for tissue fibrosis mouse model
    Patent number: 10251378
    Abstract: A transgenic mouse has a genome that includes the entire gene region of human transforming growth factor beta-1 (human TGF?1) located downstream of a mouse Podocin promoter such that expression of the human TGF?1 is controlled by the mouse Podocin promoter. The human TGF?1 contains 7 exons and 6 introns, the human TGF?1 is expressed in a kidney of the mouse as non-active TGF?1 and becomes active TGF?1 extracellularly, and the transgenic mouse spontaneously develops renal fibrosis.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: April 9, 2019
    Assignee: MIE UNIVERSITY
    Inventors: Yutaka Yano, Esteban C. Gabazza, Corina Gabazza
  • TRANSGENIC MOUSE EXPRESSING KIDNEY-SPECIFIC HUMAN TGF-BETA1, AND BIOMARKER FOR TISSUE FIBROSIS MOUSE MODEL
    Publication number: 20170135328
    Abstract: A transgenic mouse has a genome that includes the entire gene region of human transforming growth factor beta-1 (human TGF?1) located downstream of a mouse Podocin promoter such that expression of the human TGF?1 is controlled by the mouse Podocin promoter. The human TGF?1 contains 7 exons and 6 introns, the human TGF?1 is expressed in a kidney of the mouse as non-active TGF?1 and becomes active TGF?1 extracellularly, and the transgenic mouse spontaneously develops renal fibrosis.
    Type: Application
    Filed: June 24, 2015
    Publication date: May 18, 2017
    Inventors: Yutaka YANO, Esteban C. GABAZZA, Corina GABAZZA