Patents by Inventor Corine A. M. Vernet

Corine A. M. Vernet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Proteins, polynucleotides encoding them and methods of using the same
    Patent number: 7108972
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: September 19, 2006
    Assignee: CuraGen Corporation
    Inventors: Carol E. A. Pena, Richard A. Shimkets, Li Li, Suresh G. Shenoy, Ramesh Kekuda, Kimberly A. Spytek, Corine A. M. Vernet, Uriel M. Malyankar, Xiaojia (Sasha) Guo, Vladimir Y. Gusev, Stacie J. Casman, Ferenc L. Boldog, Katarzyna Furtak, Velizar T. Tchernev, Meera Patturajan, Esha A. Gangolli, Muralidhara Padigaru, Xiaohong Liu, Jason C. Baumgartner, Valerie Gerlach, Steven K. Spaderna, Bryan D. Zerhusen
  • Proteins and nucleic acids encoding same
    Patent number: 7109000
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: September 19, 2006
    Assignee: CuraGen Corporation
    Inventors: Shlomit R. Edinger, John R. MacDougall, Isabelle Millet, Karen Ellerman, David J. Stone, Valerie Gerlach, William M. Grosse, John P. Alsobrook, II, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess, Stacie J. Casman, Kimberly A. Spytek, Ferenc L. Boldog, Li Li, Muralidhara Padigaru, Vishnu Mishra, Meera Patturajan, Suresh G. Shenoy, Luca Rastelli, Velizar T. Tchernev, Corine A. M. Vernet, Bryan D. Zerhusen, Uriel M. Malyankar, Xiaojia Guo, Charles E. Miller, Esha A. Gangolli
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Patent number: 7034132
    Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: June 3, 2002
    Date of Patent: April 25, 2006
    Inventors: David W. Anderson, Jason C. Baumgartner, Ferenc L. Boldog, Stacie J. Casman, Shlomit R. Edinger, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, Xiaojia Guo, Tord Hjalt, Ramesh Kekuda, Li Li, John R. MacDougall, Uriel M. Malyankar, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Luca Rastelli, Richard A. Shimkets, David J. Stone, Kimberly A. Spytek, Corine A. M. Vernet, Edward Z. Voss, Bryan D. Zerhusen
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Patent number: 6974684
    Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: December 13, 2005
    Assignee: CuraGen Corporation
    Inventors: David W. Anderson, John P. Alsobrook II, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Shlomit R. Edinger, Esha A. Gangolli, Linda Gorman, Xiaojia Sasha Guo, Nikolai Khramtsov, Denise M. Lepley, John R. MacDougall, Carol E. A. Pena, John A. Peyman, Meera Patturajan, Daniel K. Rieger, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, Corine A. M. Vernet, Edward Z. Voss, Mei Zhong
  • Novel polypeptides and nucleic acids encoding same
    Publication number: 20040121380
    Abstract: The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Application
    Filed: October 20, 2003
    Publication date: June 24, 2004
    Inventors: Raymond J. Taupier, Kumud Majumder, Steven K. Spaderna, Glennda Smithson, Peter S. Mezes, Corine A.M. Vernet
  • Novel proteins and nucleic acids encoding same
    Publication number: 20040086875
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 4, 2002
    Publication date: May 6, 2004
    Inventors: Michele L. Agee, John P. Alsobrook, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, John S. Chant, Amitabha Chaudhuri, Vincent A. DiPippo, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Esha A. Gangolli, Linda Gorman, Valerie Gerlach, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Li Li, Uriel M. Malyankar, John R. MacDougall, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Chean Eng. Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Steven K. Spaderna, Kimberly A. Spytek, Raymond J. Taupier, Corine A.M. Vernet, Bryan D. Zerhusen, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040072997
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 3, 2003
    Publication date: April 15, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Catherine E. Burgess, Shlomit R. Edinger, Karen Ellerman, Katarzyna Furtak, Esha A. Gangolli, Valerie Gerlach, Jennifer A. Gilbert, Erik Gunther, Linda Gorman, Xiaojia (Sasha) Guo, Weizhen Ji, Li Li, Charles E. Miller, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, John R. MacDougall, Vishnu Mishra, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Suresh G. Shenoy, Raymond J. Taupier, Corine A.M. Vernet, Mei Zhong, Uriel M. Malyankar, Isabelle Millet, Ramesh Kekuda, William M. Grosse
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040067490
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: September 6, 2002
    Publication date: April 8, 2004
    Inventors: Mei Zhong, Li Li, Linda Gorman, Kimberly A. Spytek, Ramesh Kekuda, Raymond J. Taupier, David W. Anderson, Corine A.M. Vernet, Elina Catterton, Charles E. Miller, Suresh G. Shenoy, Meera Patturajan, Carol E. A. Pena, Velizar T. Tchernev, Muralidhara Padigaru, Vladimir Y. Gusev, Uriel M. Malyankar, Catherine E. Burgess, Valerie Gerlach, Stacie J. Casman, Daniel K. Rieger, William M. Grosse, Glennda Smithson, John A. Peyman, Gary Starling, Mark E. Rothenberg, William J. LaRochelle, Richard A. Shimkets, Julie Crabtree, Luca Rastelli, Edward Z. Voss, Ferenc L. Boldog, Shlomit R. Edinger, Isabelle Millet, John R. MacDougall, Karen Ellerman, Andrei Chapoval
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040067882
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 5, 2002
    Publication date: April 8, 2004
    Inventors: John P. Alsobrook, Enrique Alvarez, David W. Anderson, Melanie Baron, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Andrei Chapoval, Mohanraj Dhanabal, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Seth Ettenberg, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, William M. Grosse, Xiaojia (Sasha) Guo, Craig Hackett, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Denise M. Lepley, Li Li, John R. MacDougall, Uriel M. Malyankar, Ann Mazur, Kelly McQueeney, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Glennda Smithson, Steven K. Spaderna, Gary Starling, Kimberly A. Spytek, David J. Stone, Velizar T. Tchernev, Nancy Twomlow, Corine A.M. Vernet, Bryan D. Zerhusen, Edward Z. Voss, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040067505
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: May 1, 2003
    Publication date: April 8, 2004
    Inventors: Enrique Alvarez, David Anderson, Ferenc Boldog, Elina Catterton, Shlomit R. Edinger, Elma Fernandes, Valerie Gerlach, Linda Gorman, William Grosse, Xiaojia (Sasha) Guo, Weizhen Ji, Ramesh Kekuda, Li Li, John R. MacDougall, Muralidhara Padigaru, Meera Patturajan, Jeffery D. Peterson, Luca Rastelli, Richard Shimkets, Kimberly Spytek, David J. Stone, Corine A.M. Vernet, Edward Voss, Mei Zhong
  • Novel proteins and nucleic acids encoding same
    Publication number: 20040058338
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: December 2, 2002
    Publication date: March 25, 2004
    Inventors: Michele L. Agee, John P. Alsobrook, David W. Anderson, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, Elina Catterton, Vincent A. DiPippo, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, Bonnie Gould Rothberg, Xiaojia Sasha Guo, John L. Herrmann, Yuan-Di Halvorsen, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, William J. LaRochelle, Denise M. Lepley, Li Li, John R. MacDougall, Charles E. Miller, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Glennda Smithson, Steven K. Spaderna, Kimberly A. Spytek, David J. Stone, Raymond J. Taupier, Corine A.M. Vernet, Edward Z. Voss, Mei Zhong
  • Proteins and nucleic acids encoding same
    Publication number: 20040052806
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 4, 2002
    Publication date: March 18, 2004
    Inventors: Ramesh Kekuda, John P. Alsobrook, Velizar T. Tchernev, Xiaohong Liu, Kimberly A. Spytek, Meera Patturajan, William M. Grosse, Denise M. Lepley, Catherine E. Burgess, Corine A.M. Vernet, Li Li, Linda Gorman, Shlomit R. Edinger, Paul Sciore, Karen Ellerman, Uriel M. Malyankar, Mark E. Rothenberg, David J. Stone, Ferenc L. Boldog, Xiaojia (Sasha) Guo, Suresh G. Shenoy, David W. Anderson, Muralidhara Padigaru, Raymond J. Taupier, Charles E. Miller, Andrew Eisen
  • Endozepine-like polypeptides and polynucleotides encoding same
    Publication number: 20040048248
    Abstract: Disclosed herein are novel human nucleic acid sequences which encode endozepine-like polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving this novel human endozepine-like nucleic acid and protein.
    Type: Application
    Filed: February 27, 2002
    Publication date: March 11, 2004
    Inventors: Sudhirdas K. Prayaga, Richard A. Shimkets, Kumud Majumder, Andrew Eisen, Corine A.M. Vernet, Steven K. Spaderna, Jason Baumgartner, Linda Gorman, Vladimir Gusev, Muralidhara Padigaru, Meera Patturajan, Velizar Tchernev, Li Li
  • Novel proteins and nucleic acids encoding same
    Publication number: 20040048256
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: September 6, 2002
    Publication date: March 11, 2004
    Inventors: Michele L. Agee, John P. Alsobrook, David W. Anderson, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Elina Catterton, John S. Chant, Amitabha Chaudhuri, Julie Bokor, Vincent A. DiPippo, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Esha A. Gangolli, Valerie Gerlach, Loic Giot, Linda Gorman, Xiaojia (Sasha) Guo, Vladimir Y. Gusev, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Martin D. Leach, Denise M. Lepley, Li Li, Xiaohong Liu, Uriel M. Malyankar, Charles E. Miller, Chean Eng Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Steven K. Spaderna, Kimberly A. Spytek, Raymond J. Taupier, Nancy Twomlow, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Mei Zhong
  • Novel proteins and nucleic acids encoding same
    Publication number: 20040043929
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 3, 2003
    Publication date: March 4, 2004
    Inventors: David W. Anderson, Robert A. Ballinger, Jason C. Baumgartner, Catherine E. Burgess, Stacie J. Casman, John S. Chant, Constance Berghs, Esha A. Gangolli, Shlomit R. Edinger, Karen Ellerman, Katarzyna Furtak, Valerie Gerlach, Jennifer A. Gilbert, Erik Gunther, Linda Gorman, Xiaojia Sasha Guo, Weizhen Ji, Li Li, Xiaohong Liu, Charles E. Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, John R. MacDougall, Vishnu Mishra, Carol E.A. Pena, Steven K. Spaderna, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Suresh G. Shenoy, Tatiana Ort, Raymond J. Taupier, Velizar T. Tchernev, Corine A.M. Vernet, Adam R. Wolenc, Bryan D. Zerhusen, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040043928
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: August 1, 2002
    Publication date: March 4, 2004
    Inventors: Ramesh Kekuda, Charles E. Miller, Meera Patturajan, Carol E. A. Pena, Daniel K. Rieger, Richard A. Shimkets, Bryan D. Zerhusen, Li Li, Weizhen Ji, Muralidhara Padigaru, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Linda Gorman, Mario W. Leite, Corine A.M. Vernet, David W. Anderson, Xiaojia Sasha Guo, Mei Zhong, Valerie Gerlach, Luca Rastelli, Tord Hjalt, Kimberly A. Spytek, Shlomit R. Edinger, Karen Ellerman, Uriel M. Malyankar, John R. MacDougall, David J. Stone, John P. Alsobrook, Denise M. Lepley, Catherine E. Burgess, Kumud Majumder, Adam R. Wolenc, Glennda Smithson, Jason C. Baumgartner
  • Novel proteins and nucleic acids encoding same
    Publication number: 20040043382
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
    Type: Application
    Filed: March 7, 2002
    Publication date: March 4, 2004
    Inventors: Muralidhara Padigaru, Kimberly A. Spytek, Suresh G. Shenoy, Raymond J. Taupier, Carol E. A. Pena, Li Li, Bryan D. Zerhusen, Vladimir Y. Gusev, Weizhen Ji, Linda Gorman, Charles E. Miller, Ramesh Kekuda, Meera Patturajan, Esha A. Gangolli, Corine A.M. Vernet, Xiaojia Sasha Guo, Velizar T. Tchernev, Elma R. Fernandes, Stacie J. Casman, Uriel M. Malyankar, Valerie Gerlach, Yi Liu, David W. Anderson, Steven K. Spaderna, Elina Catterton, Mario W. Leite, Haihong Zhong, John P. Alsobrook, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040038230
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 4, 2002
    Publication date: February 26, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, John S. Chant, Andrei Chapoval, Amitabha Chaudhuri, Shlomit R. Edinger, Andrew Eisen, Esha A. Gangolli, Valerie Gerlach, Xiaojia Sasha Guo, Weizhen Ji, Nikolai V. Khramtsov, Mario W. Leite, Li Li, Peter S. Mezes, Isabelle Millet, Chean Eng Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Luca Rastelli, Daniel K. Rieger, Kerry E. Quinn Senger, Glennda Smithson, Steven K. Spaderna, Kimberly A. Spytek, David J. Stone, Nancy Twomlow, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040038877
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: October 1, 2002
    Publication date: February 26, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, Elina Catterton, Shlomit R. Edinger, Karen Ellerman, Valerie Gerlach, Linda Gorman, Xiaojia (Sasha) Guo, Weizhen Ji, Ramesh Kekuda, Martin D. Leach, Li Li, Charles E. Miller, Meera Patturajan, Daniel K. Rieger, Mark E. Rothenberg, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, Raymond J. Taupier, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Mei Zhong
  • Polypeptides and nucleic acids encoding same
    Publication number: 20040033971
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention farther discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: December 19, 2001
    Publication date: February 19, 2004
    Inventors: Esha A. Gangolli, Meera Patturajan, Corine A.M. Vernet, Uriel M. Malyankar, Ramesh Kekuda, David J. Stone, David Anderson, Richard A. Shimkets, Catherine E. Burgess, Bryan D. Zerhusen, Xiaohong Liu, Kimberly A. Spytek, Stacie J. Casman, Ference L. Boldog, Glennda Smithson, Li Li, Weizhen Ji, John R. MacDougall