Abstract: A method is provided for utilizing multi-omic data indices for tumor profiling. The method can comprise storing a plurality of multi-omic data indices, wherein each of the plurality of multi-omic data indices comprises cancer-specific tokenized data; ingesting additional multi-omic data and any annotations associated with the additional multi-omic data, the additional multi-omic data related to one or more indices; indexing the ingested additional multi-omic data and annotations while preserving gene names, gene variant names and multi-omic mapping between different data streams for the same patient in the specific index, to produce tokenized ingested additional multi-omic data; receiving a user query; selecting one or more relevant multi-omic data indices based on the user query; ranking the selected one or more multi-omic data indices based on at least one of clinical actionability, pathogenicity, feature weight, or frequency; and returning the ranked one or more multi-omic data indices to the user.