Abstract: The present invention relates to genetic mutations in mitochondrial cytochrome oxidase genes that segregate with Alzheimer's disease (AD). The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset clinical symptoms. The invention further provides treatment of cytochrome oxidase dysfunction.

Abstract: Methods are described for producing recombinant DNA molecules from suitable host vectors and nucleic acids subjected to 3'-terminal transferase activity. In one embodiment, the method takes advantage of the single 3'-deoxy-adenosine monophosphate (dAMP) residues attached to the 3' termini of PCR generated nucleic acids. Vectors are prepared with recognition sequences that afford single 3'-terminal deoxy-thymidine monophosphate (dTMP) residues upon reaction with a suitable restriction enzyme. Thus, PCR generated copies of genes can be directly cloned into the vectors without need for preparing primers having suitable restriction sites therein. The invention also contemplates associated plasmid vectors and kits for implementing the methods.

Abstract: The toxin gene encoding a protein toxic to beetles of the order Coleoptera, named M-7, has been cloned and expressed. M-7 is a novel Bacillus thuringiensis strain which has been deposited with a recognized culture repository.

Abstract: The toxin gene encoding a protein toxic to beetles of the order Coleoptera, named M-7, has been cloned and expressed. M-7 is a novel Bacillus thuringiensis strain which has been deposited with a recognized culture repository. The microbe is now known as B. thuringiensis strain san diego.

Abstract: The subject invention concerns a novel and useful insecticide with activity against elm leaf beetle. These pests do heavy damage to the crops. The insecticide of the subject invention is a B. thuringiensis microbe given the designation strain san diego. The spores or crystals of this microbe are useful to control the cotton boll weevil, the Colorado potato beetle, the alfalfa weevil, the corn rootworm, and elm leaf beetle.

Abstract: The toxin gene encoding a protein toxic to beetles of the order Coleoptera, named M-7, has been cloned and expressed. M-7 is a novel Bacillus thuringiensis strain which has been deposited with a recognized culture repository.

Abstract: The toxin gene encoding a protein toxic to beetles of the order Coleoptera, named M-7, has been cloned and expressed. M-7 is a novel Bacillus thuringiensis strain which has been deposited with a recognized culture repository.

Abstract: The toxin gene encoding a protein toxic to beetles of the order Coleoptera, named M-7, has been cloned and expressed. M-7 is a novel Bacillus thuringiensis strain which has been deposited with a recognized culture repository. The microbe is now known as B. thuringiensis strain san diego.

Abstract: The subject invention concerns a novel and useful insecticide with activity against insect pests of cotton, potato, alfalfa and corn crops. These pests do heavy damage to the crops. The insecticide of the subject invention is a B. thuringiensis microbe given the designation strain san diego. The spores or crystals of this microbe are useful to control the cotton boll weevil, the Colorado potato beetle, the alfalfa weevil, and the corn rootworm.

Abstract: The toxin gene encoding a protein toxic to beetles of the order Coleoptera, named M-7, has been cloned and expressed. M-7 is a novel Bacillus thuringiensis strain which has been deposited with a recognized culture repository. The microbe is now known as B. thuringiensis strain san diego.

Abstract: The subject invention concerns a novel and useful insecticide with activity against insect pests of the order Coleoptera. Pests in this order do heavy damage to crops, e.g., corn. The insecticide of the subject invention is a novel B. thuringiensis microbe given the specie designation M-7. The spores or crystal of this microbe are useful to control Coleoptera pests in various environments.