Patents by Inventor Corinne MALPUECH-BRUGERE

Corinne MALPUECH-BRUGERE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10238695
    Abstract: Composition containing a microorganism, preferably an Archaea, expressing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein, capable of metabolizing trimethylamine (TMA) in the presence of hydrogen in a human cavity, such as the intestine or the vagina, for use as a medicament for treating, reducing or eliminating TMA at the level of the human cavity. In addition, a composition containing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein. These compositions are of use for treating trimethylaminuria, for treating vaginal fluids in the case of bacterial vaginosis and for reducing or eliminating odours due to TMA. These compositions are also of use for reducing the level of plasma TMAO, for preventing the formation of atheroma plaques and/or for preventing cardiovascular diseases.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: March 26, 2019
    Assignee: UNIVERSITE D'AUVERGNE CLERMONT I
    Inventors: Jean-François Brugere, Guillaume Borrel, Paul William O'Toole, Corinne Malpuech-Brugere, Monique Alric
  • Publication number: 20160074440
    Abstract: Composition containing a microorganism, preferably an Archaea, expressing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein, capable of metabolizing trimethylamine (TMA) in the presence of hydrogen in a human cavity, such as the intestine or the vagina, for use as a medicament for treating, reducing or eliminating TMA at the level of the human cavity. In addition, a composition containing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein. These compositions are of use for treating trimethylaminuria, for treating vaginal fluids in the case of bacterial vaginosis and for reducing or eliminating odours due to TMA. These compositions are also of use for reducing the level of plasma TMAO, for preventing the formation of atheroma plaques and/or for preventing cardiovascular diseases.
    Type: Application
    Filed: September 27, 2013
    Publication date: March 17, 2016
    Inventors: Jean-François BRUGERE, Guillaume BORREL, Paul William O'TOOLE, Corinne MALPUECH-BRUGERE, Monique ALRIC