Abstract: The present application relates to compounds of formula (I), or pharmaceutically acceptable salts thereof: wherein R1 and R2 represent hydrogen or deuterium; R3 represents hydrogen, —COOH or —OH; R3? and R3? represent hydrogen, methyl, methoxy, chlorine, fluorine or cyano; R4 and R41 represent hydrogen or fluorine; R5 represents hydrogen, fluorine or (C1-C3)alkyl; R6 represents phenyl, fused phenyl, bicyclic group comprising 5 to 12 carbon atoms, heteroaryl group comprising 2 to 9 carbon atoms and comprising from 1 to 3 heteroatoms, cycloalkyl group comprising 3 to 7 carbon atoms, (C3-C6)cycloalkyl(C1-C3)alkyl group, 3 to 8 membered-heterocycloalkyl group comprising 1 or 2 heteroatoms, (C1-C6)alkyl, and phenyl(C1-C2)alkyl group; X represents —CH2—, —O— or —S—; Y represents —CH?, —N? or —CR??, wherein R? represents (C1-C3)alkyl, halogen, cyano, or (C1-C3)fluoroalkyl; R7 represents (C1-C3)alkyl, halogen atom, cyano, or (C1-C3)fluoroalkyl; R8 represents hydrogen or fluorine; R9 represents hydrogen, (C1-C3)alkyl

Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for AIk1, which plays an integral role in various disorders or conditions, such as cancer and macular degeneration. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of AIk1 in the progression of disorders associated with pathogenic angiogenesis. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Abstract: The present invention relates to recombinant human or humanized polypeptides which bind to ?5?1 integrin with high affinity and blocking function. Further, diagnostic and pharmaceutic applications of the potypeptides are disclosed.

Abstract: A double-ply paper bag provided in the vicinity of its opening with a strip supporting closure means, said strip forming two substantially facing webs, with only of the two webs being fixed to the inside face of the inner ply of the bag prior to the bag being filled and closed. A method of manufacturing such a bag, and the use of said bag for packaging food for animals.

Abstract: The invention relates to a catalyst for the partial oxidation of methane or a gaseous mixture containing methane, said catalyst which preferably has a perovskite structure has the following composition:Ln.sub.x A.sub.1-y B.sub.y O.sub.3in which x is a number such that 0<x<10, y is a number such that 0<y<1, Ln is at least one element chosen from within the group formed by rare earths, strontium and bismuth and A and B are metals of groups IV b, V b, VI b and VIII of the periodic classification of elements.

Abstract: Catalytic process for controlled oxidation of methane using microwaves, characterized in that it makes use of a catalyst exhibiting in its structure electrical charge defects and geometric deformations enabling it to absorb electromagnetic energy, or microwaves, under the effect of an electromagnetic field.