Patents by Inventor Corinne Sinquin

Corinne Sinquin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Marine Bacterial Exopolysaccharide Derivatives and Uses Thereof in the Treatment of Mucopolysaccharidoses
    Publication number: 20230233598
    Abstract: The invention provides low-molecular-weight over-sulfated polysaccharides with anti-heparanase activity prepared from marine native exopolysaccharides excreted by mesophilic marine bacteria from a deep-sea hydrothermal environment and relates to the use of these low-molecular-weight over-sulfated polysaccharides for the prevention or treatment of mucopolysaccharidoses, in particular mucopolysaccharidoses type III (Sanfilippo syndrome).
    Type: Application
    Filed: July 1, 2021
    Publication date: July 27, 2023
    Applicants: Institut Francais de Recherche Pour l'Exploitation de la Mer (IFREMER), Fondation Sanfilippo Suisse
    Inventors: Sylvia Colliec-Jouault, Corinne Sinquin, Agata Zykwinska, Ariane De Agostini, Jean-Christophe Tille, Noémi Veraldi, Isabelle Dentant-Quadri, Jennifer Mbosso Beffort, Nawel Zouggari
  • Anti-metastatic marine bacterial exopolysaccharide derivative and uses thereof
    Patent number: 11219638
    Abstract: The invention provides a low-molecular-weight (15 kDa) over-sulfated exopolysaccharide (GYS15) prepared from a marine native exopolysaccharide excreted by a mesophilic marine bacterium from a deep-sea hydrothermal environment, and relates to the use of this low-molecular-weight over-sulfated exopolysaccharide for the prevention or inhibition of metastases formation.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: January 11, 2022
    Assignees: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE DE NANTES, INSERM (Institut National de la Santé et de la Recherche Médicale), CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
    Inventors: Sylvia Colliec-Jouault, Corinne Sinquin, Jacqueline Ratiskol, Dominique Heymann, Carmen Ruiz-Velasco, Julie Chesneau
  • Sulfated depolymerized derivatives of exopolysaccharides (EPS) from mesophilic marine bacteria, method for preparing same, and uses thereof in tissue regeneration
    Patent number: 10105393
    Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: October 23, 2018
    Assignees: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5
    Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
  • AN ANTI-METASTATIC MARINE BACTERIAL EXOPOLYSACCHARIDE DERIVATIVE AND USES THEREOF
    Publication number: 20180280427
    Abstract: The invention provides a low-molecular-weight (15 kDa) over-sulfated exopolysaccharide (GYS15) prepared from a marine native exopolysaccharide excreted by a mesophilic marine bacterium from a deep-sea hydrothermal environment, and relates to the use of this low-molecular-weight over-sulfated exopolysaccharide for the prevention or inhibition of metastases formation.
    Type: Application
    Filed: September 28, 2016
    Publication date: October 4, 2018
    Inventors: Sylvia Colliec-Jouault, Corinne Sinquin, Jacqueline Ratiskol, Dominique Heymann, Carmen Ruiz-Velasco, Julie Chesneau
  • SULFATED DEPOLYMERIZED DERIVATIVES OF EXOPOLYSACCHARIDES (EPS) FROM MESOPHILIC MARINE BACTERIA, METHOD FOR PREPARING SAME, AND USES THEROF IN TISSUE REGENERATION
    Publication number: 20150344848
    Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.
    Type: Application
    Filed: August 10, 2015
    Publication date: December 3, 2015
    Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
  • Sulfated depolymerized derivatives of exopolysaccharides (EPS) from mesophilic marine bacteria, method for preparing same, and uses thereof in tissue regeneration
    Patent number: 9125883
    Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: September 8, 2015
    Assignees: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5
    Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
  • Sulfated Depolymerized Derivatives of Exopolysaccharides (EPS) From Mesophilic Marine Bacteria, Method For Preparing Same, And Uses Thereof In Tissue Regeneration
    Publication number: 20140037597
    Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.
    Type: Application
    Filed: October 11, 2013
    Publication date: February 6, 2014
    Applicants: UNIVERSITY RENE DESCARTES PARIS 5, INSTITUT FRANCAIS DE RECHERCHE POUR L' EXPLOITATION DE LA MER (IFREMER)
    Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
  • CHONDROGENIC DIFFERENTIATION MEDIA AND METHODS FOR INDUCING CHONDROGENIC DIFFERENTIATION OF CELLS
    Publication number: 20130336937
    Abstract: The invention provides chondrogenic differentiation media comprising chondrogenic growth factors and low-molecular-weight sulfated polysaccharide derivatives of marine native exopolysaccharides (EPS) excreted by mesophilic marine bacteria from deep-sea hydrothermal environments. The invention relates to methods for inducing chondrogenic differentiation in pluripotent or multipotent cells, to cartilage tissues obtained by such methods, and to the use of such cartilage tissues for therapeutic purposes.
    Type: Application
    Filed: March 16, 2012
    Publication date: December 19, 2013
    Applicants: Institut National de la Sante et de Ia Recherche Medicale, UNIVERSITE DE NANTES, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER
    Inventors: Emilie Rederstorff, Corinne Sinquin, Jacqueline Ratiskol, Sylvia Colliec-Jouault, Jérome Guicheux, Pierre Weiss, Christophe Merceron
  • Sulfated depolymerized derivatives of expolysaccharides (EPS) from mesophilic marine bacteria, method for preparing the same, and uses thereof in tissue regeneration
    Patent number: 8598142
    Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: December 3, 2013
    Assignees: Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), Universite Rene Descartes Paris 5
    Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
  • METHOD FOR DEPOLYMERISING POLYSACCHARIDES BY MEANS OF MECHANICAL MILLING
    Publication number: 20130032650
    Abstract: A method for controlled reduction of the weight average molar mass of a polysaccharide down to a lower and determined weight average molar mass, which method includes a step for mechanical milling of the polysaccharide by a ball mill, until the polysaccharide having the desired weight average molar mass is obtained.
    Type: Application
    Filed: November 29, 2010
    Publication date: February 7, 2013
    Applicants: CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE - CNRS, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER-IFREMER, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6 )
    Inventors: Claire Boisset, Tinaig Le Costaouec, Joelle Cozien, Corinne Sinquin, Jacqueline Ratiskol, William Helbert, Gaelle Correc, Veronique Larreta Garde
  • USE OF A POLYSACCHARIDE WHICH IS EXCRETED BY THE VIBRIO DIABOLICUS SPECIES FOR THE REGENERATION AND PROTECTION OF THE PERIODONTIUM
    Publication number: 20110305647
    Abstract: The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the regeneration and protection of the non-mineralised connective tissue of the periodontium.
    Type: Application
    Filed: June 17, 2011
    Publication date: December 15, 2011
    Applicant: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER)
    Inventors: Karim SENNI, Corinne SINQUIN, Sylvia COLLIEC-JOUAULT, Gaston-Jacques GODEAU, Jean GUEZENNEC
  • Sulfated Depolymerized Derivatives of Expolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing the Same, and Uses Thereof in Tissue Regeneration
    Publication number: 20110245199
    Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.
    Type: Application
    Filed: January 7, 2011
    Publication date: October 6, 2011
    Applicants: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5
    Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
  • Bone substitute comprising fucans and methods of making and use thereof
    Patent number: 7951391
    Abstract: The present invention relates to the use of fucans with a weight-average molar mass of between 5000 and 100 000 g/mol, for the purposes of bone grafting, engineering and regeneration.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: May 31, 2011
    Assignees: Universite Rene Descartes Paris 5, Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER)
    Inventors: Sylvie Igondjo-Tchen Changotade, Karim Senni, Alexandrine Foucault-Bertaud, Grégory Korb, Maya Brigitte Baroukh, Jean-Louis Saffar, Gaston-Jacques Godeau, Corinne Sinquin, Sylvia Colliec-Jouault, Patrick Durand
  • Use of low-molecular-weight highly sulfated polysaccharide derivatives for modulating angiogenesis
    Patent number: 7833990
    Abstract: The invention relates to the use of certain low-molecular weight highly sulphated polysaccharide derivatives obtained from a bacterial polysaccharide for preparing a pharmaceutical composition suitable for modulating angiogenesis, particularly for use in accelerating vascular endothelial repair with a low haemorrhage risk in the event of thrombotic injuries.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: November 16, 2010
    Assignees: Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), Universite Rene Descartes Paris 5
    Inventors: Sabine Matou, Sylvia Colliec-Jouault, Dominique Helley, Jacqueline Ratiskol, Corinne Sinquin, Claire Boisset, Jean Guezennec, Anne-Marie Fischer
  • USE OF FUCANS FOR THE PURPOSE OF BONE GRAFTING, ENGINEERING AND REGENERATION
    Publication number: 20090043399
    Abstract: The present invention relates to the use of fucans with a weight-average molar mass of between 5000 and 100 000 g/mol, for the purposes of bone grafting, engineering and regeneration.
    Type: Application
    Filed: February 21, 2007
    Publication date: February 12, 2009
    Applicant: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (FREMER)
    Inventors: Sylvie Igondjo-Tchen Changotade, Karim Senni, Alexandrine Foucault-Bertaud, Gregory Korb, Maya Brigitte Baroukh, Jean-Louis Saffar, Gaston-Jacques Godeau, Corinne Sinquin, Sylvia Colliec-Jouault, Patrick Durand
  • USE OF A POLYSACCHARIDE WHICH IS EXCRETED BY THE VIBRIO DIABOLICUS SPECIES FOR THE REGENERATION AND PROTECTION OF THE PERIODONTIUM
    Publication number: 20090028924
    Abstract: The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the re-generation and protection of the non-mineralised connective tissue of the periodontium.
    Type: Application
    Filed: December 6, 2007
    Publication date: January 29, 2009
    Applicant: UNIVERSITE RENE DESCARTES PARIS 5
    Inventors: Karim Senni, Corinne Sinquin, Sylvia Colliec-Jouault, Gaston-Jacques Godeau, Jean Guezennec
  • Use of a Polysaccharide Which is Excreted by the Vibrio Diabolicus Species For the Engineering of Non-Mineralized Connective Tissue
    Publication number: 20080317860
    Abstract: The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the engineering of non-mineralised connective tissues, in particular for skin and cartilage engineering.
    Type: Application
    Filed: December 6, 2006
    Publication date: December 25, 2008
    Applicants: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5
    Inventors: Karim Senni, Corinne Sinquin, Sylvia Colliec-Jouault, Gaston-Jacques Godeau, Jean Guezennec
  • Sulfated Depolymerized Derivatives of Exopolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing Same, and Uses Thereof in Tissue Regeneration
    Publication number: 20080131472
    Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g(m)g/ml.
    Type: Application
    Filed: June 6, 2005
    Publication date: June 5, 2008
    Applicant: UNIVERSITE RENE DESCARTIES PARIS 5
    Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gerard Raguenes, Anthony Courtois, Jean Guezennec
  • Use of Low-Molecular-Weight Highly Sulfated Polysaccharide Derivatives for Modulating Angiogenesis
    Publication number: 20070259833
    Abstract: The invention relates to the use of certain low-molecular weight highly sulphated polysaccharide derivatives obtained from a bacterial polysaccharide for preparing a pharmaceutical composition suitable for modulating angiogenesis, particularly for use in accelerating vascular endothelial repair with a low haemorrhage risk in the event of thrombotic injuries.
    Type: Application
    Filed: June 6, 2005
    Publication date: November 8, 2007
    Applicants: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (FREMER), UNIVERSITE RENE DESCARTES PARIS 5
    Inventors: Sabine Matou, Sylvia Colliec-Jouault, Dominique Helley, Jacqueline Ratiskol, Corinne Sinquin, Claire Boisset, Jean Guezennec, Anne-Marie Fischer
  • Use of fucane for regulating the reconstruction of connective tissue
    Patent number: 6559131
    Abstract: The invention concerns the use of fucanes for obtaining medicines for modulating metalloprotease and inhibiting leukocytic elastase. Said medicines help activate collagen synthesis inhibit proliferation of gingival fibroblasts, and activate proliferation of dermal fibroblasts. They are useful in particular for treating periodontal pathologies and dermal lesions.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: May 6, 2003
    Assignees: Ifremer, Centre National de la Recherche Scientifique, Universite Rene Descartes
    Inventors: Karim Senni, Bernard Pellat, Bruno Gogly, Catherine Blondin, Didier Letourneur, Jacqueline Jozefonvicz, Corinne Sinquin, Sylvia Colliec-Jouault, Patrick Durand