Abstract: The invention relates to a rotor for an agitating mill having a generally cylindrical rotor body, the outer wall of which defines an inner surface of a milling chamber, through which a feed material to be treated flows during operation of the agitating mill. A ceramic ring is arranged at the rotor end of the rotor body, the rotor end being arranged opposite the product inlet of the agitating mill. The invention also relates to an agitating mill comprising the rotor according to the invention, to the use of the rotor according to the invention in an agitating mill for producing dispersions, and to a method for producing the rotor.

Abstract: A generally cylindrical rotor (1) for an agitator mill is provided. The rotor has a rotor wall (11), a plurality of tools (13) attached to the rotor wall, a rotor separation ring (12), a rotor hub (14), and at least one connecting rod (15). The rotor (11) and the rotor separation ring (12) are clamped in the hub (14) by means of the connecting rods (15). The rotor separation ring (12) is designed as a rotationally symmetrical hollow cylinder. The rotor wall (11) is rotationally symmetrical with respect to an axis of rotation (19) and is mirror-symmetrical with respect to a plane of symmetry perpendicular to the axis of rotation. A mill comprising the rotor, a method for servicing the mill, and a stator assembly for use in a mill are also provided.

Abstract: The invention relates to transgene expression constructs—particularly self inactivating lentiviral vectors—comprising a dendritic cell specific promoter controlling the expression of autoantigen proteins, namely myelin basic protein, proteolipid protein and myelin oligodendrocyte glycoprotein, for use in the therapy of multiple sclerosis.

Abstract: The invention relates to transgene expression constructs—particularly self inactivating lentiviral vectors—comprising a dendritic cell specific promoter controlling the expression of autoantigen proteins, namely myelin basic protein, proteolipid protein and myelin oligodendrocyte glycoprotein, for use in the therapy of multiple sclerosis.

Abstract: The present invention relates to an enhanced and simplified herpes virus amplicon packaging system. The packaging system comprises a herpes virus amplicon vector and a packaging vector. In one embodiment, the packaging vector comprises a bacterial artificial chromosome (BAC) containing the HSV-1 genome. The packaging vector contains an intact pac site but is otherwise rendered packaging defective. The packaging vector can be rendered packaging defective by inserting nucleotides into the pac site, or by otherwise interfering with the capsid's ability to close, for example, by increasing the size of the DNA fragment upon which the herpes virus genome is cloned. This system can be used to package a wide range of nucleotide sequences (e.g., a therapeutic or antigenic gene) into an empty herpes virus particle taking advantage of the large transgene capacity of herpes viruses. This system can also be used as a vaccine to induce protective immunity against HSV-1, or other complex pathogens.

Abstract: We have now discovered a helper virus free herpesvirus packaging system. This system can be used to package a wide range of desired nucleotide segments, preferably a DNA segment, into an empty herpesvirus particle because of the large genomes of herpesviruses. Preferably, the herpesvirus is an alpha herpesvirus. More preferably, the herpesvirus is an alpha herpesvirus such as Varicella-Zoster virus, pseudorabies virus, or a herpes simplex virus such as HSV-1 or HSV-2. Another preferred herpesvirus is Epstein-Barr virus.

Abstract: We have now discovered a helper virus free herpesvirus packaging system. This system can be used to package a wide range of desired nucleotide segments, preferably a DNA segment, into an empty herpesvirus particle because of the large genomes of herpesviruses. Preferably, the herpesvirus is an alpha herpesvirus. More preferably, the herpesvirus is an alpha herpesvirus such as Varicella-Zoster virus, pseudorabies virus, or a herpes simplex virus such as HSV-1 or HSV-2. Another preferred herpesvirus is Epstein-Barr virus.