Abstract: Devices, systems, and methods relating to intraluminal imaging are disclosed. In an embodiment, an intraluminal imaging device is disclosed. One embodiment of the intraluminal imaging device comprises a flexible elongate member configured to be inserted into a body lumen of a patient, the flexible elongate member comprising a proximal portion and a distal portion. The intraluminal imaging device further comprises an ultrasound imaging assembly disposed at the distal portion of the flexible elongate member. The imaging assembly comprises a support member, a flexible substrate positioned around the support member, a plurality of ultrasound transducer elements integrated in the flexible substrate, and a plurality of control circuits disposed on the flexible substrate at a position proximal to the plurality of transducer elements. The plurality of control circuits has an outer profile that does not extend beyond an outer profile of the plurality of transducer elements.

Abstract: The invention is relates to multispecific antibodies that comprise an antigen binding site that binds an extracellular part of CD137 and an antigen binding site that binds an extracellular part of a second membrane protein for use in a method of treatment of a cancer in a subject in need thereof. The invention further relates to such multispecific antibodies and methods and other aspects related thereto.

Abstract: The disclosure relates to means and methods of treating a subject for a CLEC12A positive cancer. In some embodiments the method comprises treating the subject in need thereof with two or more administrations of a bispecific antibody that binds CD3 and CLEC12A, wherein in a first administration an first amount of the bispecific antibody is administered and wherein in each of the subsequent administrations the amount of bispecific antibody is higher than the amount of bispecific antibody in the first administration. In some embodiments CLEC12A positive cancer treatment methods are provided at intervals and dosing regimens that spare hemopoietic stem cell compartment allowing for recovery of normal CLEC12A positive hemopoietic cells.

Abstract: A system can collapse steps into an aggregate step to simplify analysis while maintaining underlying data that forms each of the steps collapsed into the aggregate step. The steps may or may not be related in a sequence or grouping of steps. The aggregate step may be a new step that comprises the data of the individual steps used to form the aggregate step. Alternatively, the aggregate step may be a virtual step that may reference or link to the steps used to form the aggregate step, but may not include the data itself. By forming aggregate steps, filtering and notification generation can be simplified. Further, extraneous data can be collapsed into a single aggregate step, which can be particularly advantageously when analyzing large data sets.

Abstract: The subject disclosure relates to ways to identify self-hit data collected by autonomous vehicle (AV) sensors. In some aspects, a method of the disclosed technology includes steps for generating a geometric model of an autonomous vehicle (AV), wherein the geometric model specifies physical boundaries of the AV in three-dimensional (3D) space, collecting sensor data for an environment around the AV, and identifying one or more data points, from among the collected sensor data, that correspond with a surface of the AV. Systems and machine-readable media are also provided.

Abstract: An autonomous vehicle having a lidar sensor system is described. A computing system is configured to determine that the lidar sensor system is to update a code that is included in light signals emitted by the lidar sensor system. The computing system transmits a command signal to the lidar sensor system, wherein the command signal causes the lidar sensor system to transition from emitting light signals with a first code therein to emitting light signals with a second code therein, wherein the first code is different from the second code.

Abstract: The subject disclosure relates to ways to identify self-hit data collected by autonomous vehicle (AV) sensors. In some aspects, a method of the disclosed technology includes steps for generating a geometric model of an autonomous vehicle (AV), wherein the geometric model specifies physical boundaries of the AV in three-dimensional (3D) space, collecting sensor data for an environment around the AV, and identifying one or more data points, from among the collected sensor data, that correspond with a surface of the AV. Systems and machine-readable media are also provided.

Abstract: An autonomous vehicle having a lidar sensor system is described. A computing system is configured to determine that the lidar sensor system is to update a code that is included in light signals emitted by the lidar sensor system. The computing system transmits a command signal to the lidar sensor system, wherein the command signal causes the lidar sensor system to transition from emitting light signals with a first code therein to emitting light signals with a second code therein, wherein the first code is different from the second code.

Abstract: The disclosure relates to means and methods in the treatment of cancer. The disclosure in particular relates to a method of treating a cancer in an individual with an antibody that binds LGR5 and EGFR. The invention further relates to the combination for use in such methods and to the combination for use in the manufacture of a medicament for the treatment of gastrointestinal cancer. Such antibodies are particularly useful in the treatment of gastric, esophageal, or gastro-esophageal-junction cancer.

Abstract: An autonomous vehicle having a lidar sensor system is described. A computing system is configured to determine that the lidar sensor system is to update a code that is included in light signals emitted by the lidar sensor system. The computing system transmits a command signal to the lidar sensor system, wherein the command signal causes the lidar sensor system to transition from emitting light signals with a first code therein to emitting light signals with a second code therein, wherein the first code is different from the second code.

Abstract: The subject disclosure relates to ways to identify self-hit data collected by autonomous vehicle (AV) sensors. In some aspects, a method of the disclosed technology includes steps for generating a geometric model of an autonomous vehicle (AV), wherein the geometric model specifies physical boundaries of the AV in three-dimensional (3D) space, collecting sensor data for an environment around the AV, and identifying one or more data points, from among the collected sensor data, that correspond with a surface of the AV. Systems and machine-readable media are also provided.

Abstract: An autonomous vehicle having a lidar sensor system is described. A computing system is configured to determine that the lidar sensor system is to update a code that is included in light signals emitted by the lidar sensor system. The computing system transmits a command signal to the lidar sensor system, wherein the command signal causes the lidar sensor system to transition from emitting light signals with a first code therein to emitting light signals with a second code therein, wherein the first code is different from the second code.

Abstract: An autonomous vehicle having a lidar sensor system is described. A computing system is configured to determine that the lidar sensor system is to update a code that is included in light signals emitted by the lidar sensor system. The computing system transmits a command signal to the lidar sensor system, wherein the command signal causes the lidar sensor system to transition from emitting light signals with a first code therein to emitting light signals with a second code therein, wherein the first code is different from the second code.

Abstract: The invention relates to a food processing device (100), comprising: a jar (10), a base unit (20), a vacuum mechanism (30) for sucking air from the jar (10), comprising a vacuum pump (31) arranged in the base unit (20) and a first vacuum conduit (32) extending through the base unit (20), and a lid (40) for covering the jar (10) and realizing air communication between the jar (10) and the base unit (20), wherein the vacuum mechanism (30) further comprises a second vacuum conduit (33) extending through the lid (40), wherein the respective vacuum conduits (32, 33) are engageable to each other through respective engaging ends (34, 35) thereof, and wherein at least one of the engaging ends (34, 35) of the respective vacuum conduits (32, 33) is displaceable between an outward position and a retracted position in the respective one of the base unit (20) and the lid (40).

Abstract: The invention relates to a food processing device (100), comprising: a jar (10), a base unit (20), a vacuum mechanism (30) for sucking air from the jar (10), comprising a vacuum pump (31) arranged in the base unit (20) and a first vacuum conduit (32) extending through the base unit (20), and a lid (40) for covering the jar (10) and realizing air communication between the jar (10) and the base unit (20), wherein the vacuum mechanism (30) further comprises a second vacuum conduit (33) extending through the lid (40), wherein the respective vacuum conduits (32, 33) are engageable to each other through respective engaging ends (34, 35) thereof, and wherein at least one of the engaging ends (34, 35) of the respective vacuum conduits (32, 33) is displaceable between an outward position and a retracted position in the respective one of the base unit (20) and the lid (40).

Abstract: The invention relates to a blender (10) for blending ingredients. The blender (10) comprises a base part (11) comprising a heating plate (22), and a container (13) for receiving said ingredients. The container (13) is detachable from the base part (11) and comprising a bottom part for contacting the heating plate (22). The base part (11) comprises a temperature sensor (23) for sensing the temperature of the bottom part. The temperature sensor (23) extends tends through the heating plate (22).

Abstract: The invention relates to a blender (10) for blending ingredients. The blender (10) comprises a base part (11) comprising a heating plate (22), and a container (13) for receiving said ingredients. The container (13) is detachable from the base part (11) and comprising a bottom part for contacting the heating plate (22). The base part (11) comprises a temperature sensor (23) for sensing the temperature of the bottom part. The temperature sensor (23) extends tends through the heating plate (22).

Abstract: Corresponding results were obtained with A method for obtaining a plant, in particular a cultivated lettuce plant (L. sativa), with a lasting resistance to a pathogen, in particular Bremia lactucae, comprising of providing one or more specific DNA markers linked to one or more resistance genes, determining the presence of one or more resistance genes in a plant using these DNA markers, subsequently crossing a first plant comprising one or more resistance genes with a second plant comprising one or more resistance genes, and selecting from the progeny a plant in which one or more resistance genes are present by using the DNA markers. The invention further relates to the plants obtained with this method, seeds and progeny of these plants, as well as progeny thereof.

Abstract: Corresponding results were obtained with A method for obtaining a plant, in particular a cultivated lettuce plant (L. sativa), with a lasting resistance to a pathogen, in particular Bremia lactucae, comprising of providing one or more specific DNA markers linked to one or more resistance genes, determining the presence of one or more resistance genes in a plant using these DNA markers, subsequently crossing a first plant comprising one or more resistance genes with a second plant comprising one or more resistance genes, and selecting from the progeny a plant in which one or more resistance genes are present by using the DNA markers. The invention further relates to the plants obtained with this method, seeds and progeny of these plants, as well as progeny thereof.

Abstract: A method for obtaining a plant, in particular a cultivated lettuce plant (L. sativa), with a lasting resistance to a pathogen, in particular Bremia lactucae, comprising of providing one or more specific DNA markers linked to one or more resistance genes, determining the presence of one or more resistance genes in a plant using these DNA markers, subsequently crossing a first plant comprising one or more resistance genes with a second plant comprising one or more resistance genes, and selecting from the progeny a plant in which one or more resistance genes are present by using the DNA markers. The invention further relates to the plants obtained with this method, seeds and progeny of these plants, as well as progeny thereof.