Patents by Inventor Cornelis J. Leenhouts

Cornelis J. Leenhouts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attaching substances to microorganisms
    Patent number: 7312311
    Abstract: The invention relates to surface display of proteins on microorganisms via the targeting and anchoring of heterologous proteins to the outer surface of cells such as yeast, fungi, mammalian, plant cells, and bacteria. The invention provides a proteinaceous substance comprising a reactive group and at least one attaching peptide including a stretch of amino acids having a sequence corresponding to at least a part of the consensus amino acid sequence listed in FIG. 10 and further includes a method for attaching a proteinaceous substance to the cell wall of a microorganism comprising the use of the attaching peptide.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: December 25, 2007
    Assignee: Applied Nanosystems B.V.
    Inventors: Girbe Buist, Cornelis J. Leenhouts, Gerard Venema, Jan Kok
  • Method to provide bacterial ghosts provided with antigens
    Patent number: 7067639
    Abstract: Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: June 27, 2006
    Assignee: Applied Nanosystems B.V.
    Inventors: Cornelis J. Leenhouts, Ranjan Ramasamy, Anton Steen, Jan Kok, Girbe Buist, Oscar P. Kuipers
  • Food-grade vector suitable for transforming a food-grade host cell use of said vector for transforming food-grade host cells and use of said transformed cells in biotransformation processes
    Patent number: 5627072
    Abstract: A food-grade vector is provided which is suitable for transforming a food-grade host cell and is incapable of replicating autonomously in the host cell due to deletion of the replicase gene.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: May 6, 1997
    Assignee: Van Den Bergh Foods Co., Division of Conopco Inc.
    Inventors: Cornelis J. Leenhouts, John D. Marugg, Cornelis T. Verrips