Patents by Inventor Cornelis J. Van der Laken

Cornelis J. Van der Laken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilization of carboxyl esterase
    Patent number: 5538876
    Abstract: Carboxyl esterase is inactivated by several chemical compounds such as naproxen or diclofop. By substituting or modifying certain basic residues of the carboxyl esterase, this enzyme shows improved stability properties during application. In this way it is possible to perform stereospecific hydrolysis reactions on industrial scale even at high substrate concentrations.
    Type: Grant
    Filed: August 23, 1995
    Date of Patent: July 23, 1996
    Assignee: Gist-brocades, N.V.
    Inventors: Johanna H.G.M. Mutsaers, Cornelis J. Van Der Laken, Cornelis P. Broekhuizen, Wilhemus J. Quax
  • Stabilization of carboxyl esterase
    Patent number: 5238831
    Abstract: Carboxyl esterase is inactivated by several chemical compounds such as naproxen or diclofop. By substituting or modifying certain basic residues of the carboxyl esterase, this enzyme shows improved stability properties during application. In this way it is possible to perform stereospecific hydrolysis reactions on industrial scale even at high substrate concentrations.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: August 24, 1993
    Assignee: Gist-brocades
    Inventors: Johanna H. G. M. Mutsaers, Cornelis J. van der Laken, Cornelis P. Broekhuizen, Wilhemus J. Quax
  • Microbial purified esterases
    Patent number: 5037751
    Abstract: A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula ##STR1## or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R.sub.1 represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula ##STR2## wherein R.sub.
    Type: Grant
    Filed: September 11, 1989
    Date of Patent: August 6, 1991
    Assignee: Gist-Brocades N.V.
    Inventors: Mauro A. Bertola, Arthur F. Marx, Hein S. Koger, Wilhelmus J. Quax, Cornelis J. van der Laken, Gareth T. Phillips, Brian W. Robertson, Peter D. Watts
  • Process for the purification of serum albumin
    Patent number: 4990447
    Abstract: Recombinantly produced serum albumin is purified in a series of steps, initially employing an alkaline precipitation, optionally followed by incubation with an anion exchange absorbent, followed by affinity chromatography employing a hydrophobic solid phase and using a water-soluble lipid anion as desorbens in the aqueous phase.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: February 5, 1991
    Assignee: Gist-Brocades NV
    Inventors: Boudewijn W. Konig, Michiel N. Hamers, Cornelis J. van der Laken
  • Process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula
    Patent number: 4886750
    Abstract: A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula ##STR1## or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R.sub.1 represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula ##STR2## wherein R.sub.
    Type: Grant
    Filed: January 6, 1987
    Date of Patent: December 12, 1989
    Assignees: Gist-Brocades N.V., Shell Internationale Research Mattschappij B.V.
    Inventors: Mauro A. Bertola, Arthur F. Marx, Hein S. Koger, Wilhelmus J. Quax, Cornelis J. Van der Laken, Gareth T. Phillips, Brian W. Robertson, Peter D. Watts