Patents by Inventor Cornelis Johannes Leenhouts

Cornelis Johannes Leenhouts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial ghosts provided with antigens
    Patent number: 6896887
    Abstract: Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: May 24, 2005
    Assignee: Applied Nanosystems B.V.
    Inventors: Cornelis Johannes Leenhouts, Ranjan Ramasamy, Anton Steen, Jan Kok, Girbe Buist, Oscar Paul Kuipers
  • Export and modification of (poly)peptides in the lantibiotic way
    Patent number: 6861236
    Abstract: The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intracellular posttranslational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether-containing peptides and dehydroalanine/dehydrobutyrine-containing.peptides, wherein thioether rings may be formed extracellularly.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: March 1, 2005
    Assignee: Applied Nanosystems B.V.
    Inventors: Gert Nikolaas Moll, Cornelis Johannes Leenhouts
  • Export and modification of (poly)peptides in the lantibiotic way
    Publication number: 20040009550
    Abstract: The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether containing peptides and dehydroalanine/dehydrobutyrine-containing peptides, wherein extracellularly thioether rings may be formed.
    Type: Application
    Filed: February 7, 2003
    Publication date: January 15, 2004
    Inventors: Gert Nikolaas Moll, Cornelis Johannes Leenhouts
  • Bacterial ghosts prvided with antigens
    Publication number: 20030186851
    Abstract: Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material.
    Type: Application
    Filed: December 13, 2002
    Publication date: October 2, 2003
    Inventors: Cornelis Johannes Leenhouts, Ranjan Ramasamy, Anton Steen, Jan Kok, Girbe Buist, Oscar Paul Kuipers
  • Method to provide bacterial ghosts provided with antigens
    Publication number: 20030180816
    Abstract: Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material.
    Type: Application
    Filed: December 16, 2002
    Publication date: September 25, 2003
    Inventors: Cornelis Johannes Leenhouts, Ranjan Ramasamy, Anton Steen, Jan Kok, Girbe Buist, Oscar Paul Kuipers