Patents by Inventor Cornelis Korstiaan Van Der Ent

Cornelis Korstiaan Van Der Ent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid quantitative test to diagnose polycystic kidney disease
    Patent number: 11988661
    Abstract: The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: May 21, 2024
    Assignees: UMC Utrecht Holding, B.V., Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Jeffrey Matthijn Beekman, Johanna Florentia Dekkers, Cornelis Korstiaan Van Der Ent, Johannes Carolus Clevers
  • RAPID QUANTITATIVE ASSAY TO MEASURE CFTR FUNCTION IN A PRIMARY INTESTINAL CULTURE MODEL
    Publication number: 20210333266
    Abstract: The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.
    Type: Application
    Filed: May 7, 2021
    Publication date: October 28, 2021
    Applicants: UMC Utrecht Holding, B.V., Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Jeffrey Matthijn Beekman, Johanna Florentia Dekkers, Cornelis Korstiaan Van Der Ent, Johannes Carolus Clevers
  • Antimicrobial peptides and their use
    Patent number: 11130781
    Abstract: The invention relates to the field of antibiotics, more specifically to peptide antibiotics, such as antimicrobial peptides and their use in the treatment of diseases associated with microbial infections. In particular, the invention provides a peptide with antimicrobial activity comprising an amino acid sequence RRWVQRWIRRWR (SEQ ID NO: 24) or an analogue thereof.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: September 28, 2021
    Assignees: Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.
    Inventors: Marinus Van Eijk, Albert Van Dijk, Hendrik Peter Haagsman, Cornelis Korstiaan Van Der Ent
  • Identifying drug candidates for treating polycystic kidney disease using organoids generated from primary cells
    Patent number: 11035852
    Abstract: The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: June 15, 2021
    Assignees: UMC Utrecht Holding, B.V., Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Jeffrey Matthijn Beekman, Johanna Florentia Dekkers, Cornelis Korstiaan Van Der Ent, Johannes C. Clevers
  • ANTIMICROBIAL PEPTIDES AND THEIR USE
    Publication number: 20200190145
    Abstract: The invention relates to the field of antibiotics, more specifically to peptide antibiotics, such as antimicrobial peptides and their use in the treatment of diseases associated with microbial infections. In particular, the invention provides a peptide with antimicrobial activity comprising an amino acid sequence RRWVQRWIRRWR (SEQ ID NO: 24) or an analogue thereof.
    Type: Application
    Filed: April 24, 2018
    Publication date: June 18, 2020
    Inventors: Marinus Van Eijk, Albert Van Dijk, Hendrik Peter Haagsman, Cornelis Korstiaan Van Der Ent
  • RAPID QUANTITATIVE ASSAY TO MEASURE CFTR FUNCTION IN A PRIMARY INTESTINAL CULTURE MODEL
    Publication number: 20190383799
    Abstract: The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.
    Type: Application
    Filed: June 8, 2018
    Publication date: December 19, 2019
    Applicants: UMC Utrecht Holding B.V., Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Jeffrey Matthijn Beekman, Johanna Florentia Dekkers, Cornelis Korstiaan Van Der Ent, Johannes C. Clevers
  • Rapid quantitative assay to measure CFTR function in a primary intestinal culture model
    Patent number: 10006904
    Abstract: The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: June 26, 2018
    Assignees: UMC Utrecht Holding B.V., Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Jeffrey Matthijn Beekman, Johanna Florentia Dekkers, Cornelis Korstiaan Van Der Ent, Johannes C. Clevers
  • A RAPID QUANTITATIVE ASSAY TO MEASURE CFTR FUNCTION IN A PRIMARY INTESTINAL CULTURE MODEL
    Publication number: 20150276719
    Abstract: The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.
    Type: Application
    Filed: December 19, 2012
    Publication date: October 1, 2015
    Applicants: UMC Utrecht Holding B.V., Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Jeffrey Matthijn Beekman, Johanna Florentia Dekkers, Cornelis Korstiaan Van Der Ent, Johannes C. Clevers
  • RAPID QUANTITATIVE ASSAY TO MEASURE CFTR FUNCTION IN A PRIMARY INTESTINAL CULTURE MODEL
    Publication number: 20150011420
    Abstract: The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.
    Type: Application
    Filed: December 19, 2012
    Publication date: January 8, 2015
    Applicants: UMC Utrecht Holding B.V., Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Jeffrey Matthijn Beekman, Johanna Florentia Dekkers, Cornelis Korstiaan Van Der Ent, Johannes C. Clevers