Abstract: X-ray sources emit X-rays into an examination region along different projection views. An X-ray detector array detects the X-rays emitted by the X-ray sources after passing through the examination region. X-ray imaging data are acquired by cycling through the X-ray sources with each step of the cycle including: switching an active X ray source on to emit X-rays and the other X ray sources off to not emit X rays, and acquiring X ray imaging data along the projection view corresponding to the active X-ray source that is switched on. Tomosynthesis image reconstruction is performed on the X ray imaging data to generate at least one volumetric image. A time sequence of spatially aligned images is produced from the time sequence of volumetric images. A perfusion image and/or a ventilation image is generated based on voxel intensity variation over time of the time sequence of spatially aligned images.

Abstract: A system and method for determining a correlation between medication intake and sleep disordered breathing, SDB, therapy outcome for a subject taking at least one type of medication and being provided with SDB therapy. The SDB therapy comprises at least positive airway pressure, PAP, therapy provided by a PAP device. Medication information, relating to a medication intake of the subject, and SDB therapy information, relating to a therapy outcome of the SDB therapy, are obtained and correlated.

Abstract: A mechanical ventilation device includes at least one electronic controller configured to receive two or more respiratory data streams, each spanning multiple breath cycles; generate a confidence band over a breath cycle for each data stream based on statistics of the data stream determined from the multiple breaths spanned by the data stream; and on a display, plot the confidence bands for the data streams on a common graph.

Abstract: A proning assessment method includes determining, from received respiratory and/or body position data, a flipping time (tflipping) when a patient is placed in a partial or full prone position; determining a target imaging time (timg,target) for acquiring imaging data to assess an impact of proning on mechanical ventilation therapy as the flipping time (tflipping) plus a predetermined time interval (?t); receiving at least one lung image of at least one lung of the patient, the at least one lung image being timestamped with an image acquisition time (timg,actual); and at least one of: (i) displaying the at least one lung image; and/or (ii) analyzing the at least one lung image to generate a proning recommendation for the patient, and displaying, on a display device, a representation of the proning recommendation.

Abstract: A system and method for quantifying a pulmonary ventilation and perfusion gradient of a lung of a subject. Local Hounsfield density histograms are generated from computed tomography imaging data and each local histogram is cross-correlated with a global Hounsfield density histogram at a plurality of different shift values. A final shift value is determined for each local histogram based on the correlation values obtained by the cross-correlation.

Abstract: A system and method for controlling a sleep disordered breathing (SDB) therapy device. Signals responsive to a subject's breathing and baroreceptor-initiated changes in sympathetic activity of the subject, while the subject is undergoing therapy using the SDB therapy device, are obtained and processed to detect a change in sympathetic activity. For changes in sympathetic activity exceeding a predetermined threshold, a determination as to whether the change is chemoreceptor-initiated or baroreceptor-initiated. A control signal for controlling the SDB therapy device is generated according to whether the change is chemoreceptor-initiated or baroreceptor-initiated.

Abstract: A system and method for generating a predictive indicator representing a difference between a PAP titration sleep session and at least one conventional sleep session. Data relating to the subject's sleep and to sleep influencing factors is obtained for both the PAP titration sleep session and the conventional sleep session, and is processed to identify any differences between the PAP titration sleep session and the conventional sleep session. A predictive indicator indicative of whether the identified difference(s), if present, satisfy a first predetermined condition is generated.

Abstract: Systems and methods are proposed for verifying whether a digital twin of abiological asset (or biological system) of a subject (110) indeed relates to the subject (110). Such proposals may be based on obtaining: a first signal comprising a value of a physiological parameter of the subject (e.g. determined by a physical and/or virtual sensor arrangement); and a second signal generated by the digital twin that simulates a value of a physiological parameter of the subject (110). By comparing the first and second signals, a verification result may then be determined.

Abstract: A respiration monitoring device includes at least one electronic processor programmed to perform a respiration monitoring method including receiving ultrasound imaging data of a diaphragm of a patient as a function of time during inspiration and expiration while the patient undergoes mechanical ventilation therapy with a mechanical ventilator; receiving respiratory data of the patient as a function of time during the inspiration and expiration while the patient undergoes the mechanical ventilation therapy; calculating an intrinsic positive end-expiratory pressure (iPEEP) value for the patient based on the ultrasound imaging data and the respiratory data; and displaying, on a display device, a representation of the calculated iPEEP value.

Abstract: A biological cell preservation or culturing arrangement (20) comprises a chamber defining a fluid retaining space (30) for retaining in use a body of fluid (34) and a deformable membrane (36) in communication with the fluid retaining space, and being manipulable by an electroactive polymer actuator arrangement (38) to undergo a defined topology change to induce in the fluid a pattern of fluid flow by which fluid is exchanged between a sub-region (46) immediately proximal the deformable membrane and a sub-region (48) removed from the deformable membrane.

Abstract: A mechanical ventilation assessment assistance device includes at least one electronic processor; and a non-transitory storage medium storing instructions readable and executable by the at least one electronic processor to perform a mechanical ventilation assessment assistance method including obtaining an image of a patient (P) receiving mechanical ventilation; generating or updating a patient-specific lung model of at least one lung of the patient based on the obtained image; simulating a response of the patient to a mechanical ventilation therapy using the generated or updated patient-specific lung model; comparing the simulated response with an actual response of the patient to the mechanical ventilation therapy; based on the comparison, determining an imaging recommendation for acquiring an image of at least one lung of the patient; and outputting the determined imaging recommendation.

Abstract: A method is provided for recording or representing captured ultrasound-derived information. The method is based on obtaining positioning information related to an ultrasound probe during execution of an ultrasound examination, and using this to associate captured data samples, or information derived therefrom, with anatomical position information for the data samples. The link between the two is achieved using an anatomical model which can relate probe surface position with anatomical body structure underlying the surface. A map can be generated of the obtained data as a function of position across the surface of the anatomical body. i.e. effectively a projection of the data onto the object 2D surface.

Abstract: A mechanical ventilation device includes an electronic controller (13) configured to: receive imaging data (22) and ventilator data associated with lungs of a patient while the patient undergoes mechanical ventilation therapy with an associated mechanical ventilator (2); determine a respiratory pressure of the patient based at least on the received ventilator data; determine a lung volume and a lung flow for at least one region of the lungs based on lung sliding data determined from the received imaging data and the determined respiratory pressure; determine a regional resistance and elastance for the at least one region of the lungs from the lung volume and the lung flow for the at least one region; and display the regional resistance and elastance for the at least one region of the lungs on a display device (14).

Abstract: A respiration monitoring device for monitoring a respiratory system of a patient includes an electronic controller configured to receive first ultrasound imaging data as a function of time acquired of a first portion of the respiratory system of the patient over a first time interval; receive second ultrasound imaging data as a function of time acquired of a second portion of the respiratory system of the patient over a second time interval wherein the second portion of the respiratory system of the patient is contralateral to the first portion of the respiratory system of the patient; and present a graphical user interface (GUI) displaying a visualization including simultaneous display of an image of the first portion of the respiratory system of the patient and an image of the second portion of the respiratory system of the patient respectively.

Abstract: The invention implements a digital twin to provide e.g. estimated measurements of one or more physiological or anatomical parameters in a way that requires less local storage space and local processing capacity. Embodiments are based on constructing and implementing a lean digital twin model or dataset by storing results of a number of full digital model simulations in advance and then using these pre-stored simulation results (42) to provide physiological parameter estimations, in place of the full digital twin model (32).

Abstract: Methods and systems for recommending at least one patient interface device from among a plurality of patient interface devices for a patient. The methods and systems monitor an initial stress response of the patient upon being exposed to each of the potential patient interface devices of the plurality and from such monitoring select a device or devices that produce lesser stress responses.

Abstract: A mechanical ventilation device includes at least one electronic controller configured to receive imaging data related to a dimension of a diaphragm of a patient during inspiration and expiration while the patient undergoes mechanical ventilation therapy with an associated mechanical ventilator; calculate a pressure value (Pl, DPl) of a chest of the patient based on at least the imaging data; and when the calculated pressure value (Pl, DPl) does not satisfy an acceptance criterion, at least one of output an alert indicative of the calculated pressure value (Pl, DPl) failing to satisfy the acceptance criterion; and output a recommended adjustment to one or more parameters of the mechanical ventilation therapy delivered to the patient.

Abstract: A diaphragm measurement device includes a non-transitory storage medium storing a patient-specific registration model for referencing ultrasound imaging data to a reference frame. At least one electronic processor is programmed to perform a diaphragm measurement method including receiving ultrasound imaging data of a diaphragm of a patient during inspiration and expiration while the patient undergoes mechanical ventilation therapy with a mechanical ventilator; calculating a diaphragm thickness metric based on the received ultrasound imaging data of the diaphragm of the patient referenced to the reference frame using the patient-specific registration model; and displaying, on a display device, a representation of the calculated diaphragm thickness metric.

Abstract: A mechanical ventilation assistance device includes at least one electronic controller configured to receive positional data of a patient; determine a position of an imaging device configured to obtain imaging data of the patient based on the received positional data; and display, on a display device, a representation of the determined position of the imaging device.

Abstract: A diaphragm measurement system (1) includes at least one electronic processor (13) programmed to perform a diaphragm measurement method (100) including receiving ultrasound imaging data (24) of a diaphragm of a patient over a time period encompassing multiple breaths; receiving respiration data of the patient over the time period; calculating a diaphragm thickness metric based on the received ultrasound imaging data of the diaphragm and the received respiration data; and displaying, on a display device (14), a representation (30) of the calculated diaphragm thickness metric.