Patents by Inventor Cornelis Wilhelmus VAN Bokhoven

Cornelis Wilhelmus VAN Bokhoven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 11.beta.-hydroxy-18-alkyl-estrane compounds
    Patent number: 4031074
    Abstract: The present invention relates to a novel process for the preparation of 11.beta.-hydroxy-18-alkyl-estrane compounds by reacting an 11.beta.-hydroxy-13-methyl-gonane compound with an excess of an acylhypoiodite to give an estrano-18,11.beta.-lactone, reacting the latter compound with a Grignard compound or an alkyl lithium compound, possibly after hydrolysis of the lactone, and reducing the thus-obtained 11.beta.-hydroxy-18-alkyl-18-ketone to the corresponding 11.beta.-hydroxy-18-alkyl-estrane compound, and to novel intermediates of the subject compounds.
    Type: Grant
    Filed: July 18, 1975
    Date of Patent: June 21, 1977
    Assignee: Akzona Incorporated
    Inventors: Hendrik Paul deJongh, Cornelis Wilhelmus VAN Bokhoven