Patents by Inventor Corrado Busi

Corrado Busi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatotropic conjugates of antiblastic drugs accomplishing a loco-regional chemotherapy of liver micrometastases after adminstration by peripheral venous route
    Publication number: 20040044178
    Abstract: Pharmaceutical compositions containing as active compound conjugates of lactosaminated albumin with antiblastic nucleosides (and their analogs) are here described. These compositions are particularly useful to increase the efficacy of the antiblastic nucleosides (and their analogs) on liver micrometastases. They preferably consist of aqueous solutions administered by parenteral route, preferably by intravenous injection. The antiblastic nucleoside of choice is 5-fluoro-2′-deoxyuridine (FUdR).
    Type: Application
    Filed: July 9, 2003
    Publication date: March 4, 2004
    Inventors: Luigi Fiume, Giuseppina Di Stefano, Corrado Busi
  • Hepatotropic conjugates of antiviral drugs carriers thereof and pharmaceutical compositions containing them
    Patent number: 6291638
    Abstract: The present invention refers to conjugated compounds of antiviral drugs having hepatotropic activity, methods of making these compounds, and compositions thereof.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: September 18, 2001
    Assignee: Laboratori Balducci S.p.a.
    Inventors: Luigi Fiume, Corrado Busi, Guiseppina Di Stefano, Alessandro Mattioli, Massimo Baldacci
  • Hepatotropic conjugates of antiviral drugs carriers thereof and pharmaceutical compositions containing them
    Patent number: 5959077
    Abstract: The present invention refers to conjugated compounds of antiviral drugs having hepatotropic activity, methods of making these compounds, and compositions thereof.
    Type: Grant
    Filed: April 1, 1998
    Date of Patent: September 28, 1999
    Assignee: Laboratori Balducci S.p.A.
    Inventors: Luigi Fiume, Corrado Busi, Giuseppina Di Stefano, Alessandro Mattioli, Massimo Baldacci
  • Process of conjugation of antiviral nucleosides with lactosaminated human albumin
    Patent number: 5594110
    Abstract: A conjugate of an antiviral nucleoside with a lactosaminated human albumin (L-HSA) and its method of preparation is described. The method of preparation involves the reaction of an antiviral phosphorylated nucleoside in the form of an imidizolide with L-HSA at a pH above 7.5 and running the reaction until the desired molar ratio of drug to L-HSA is obtained.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: January 14, 1997
    Assignee: Laboratori Baldacci SpA
    Inventors: Luigi Fiume, Corrado Busi, Giuseppina D. Stefano, Alessandro Mattioli
  • Method for the preparation of conjugates of adenine-9-beta-arabinofuranoside 5' monophosphate with lactosaminated human albumin, the obtained conjugates and therapeutically active compositions containing them
    Patent number: 4794170
    Abstract: For the preparation of conjugates of adenine-9-beta-D-arabinofuranoside 5'monophosphate (ara-AMP) with lactosaminated human albumin (L-HSA) aqueous solutions of the two components to be conjugated are brought into contact in the presence of 1-ethyl-3-(dimethylaminopropyl)-carbodiimide, by adjusting the pH in the range from slightly acidic to alkaline and by carrying out the conjugate separation. The resulting conjugate, wherein the molar ratio, as determined through spectrophotometric route, between ara-AMP and L-HSA does vary between 5 and 20, remains soluble after lyophilization even at room temperature and shows biological activity at least equivalent to that of the conjugate as prepared according to the known art.
    Type: Grant
    Filed: December 11, 1985
    Date of Patent: December 27, 1988
    Assignee: Laboratori Baldacci SpA
    Inventors: Luigi Fiume, Corrado Busi, Alessandro Mattioli, Massimo Baldacci
  • Conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin, process for the preparation thereof and pharmaceutical compositions containing it
    Patent number: 4725672
    Abstract: A conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin is therapeutically more efficacious than the free drug in the treatment of chronical hepatitis induced from Virus B. For the preparation of the conjugate an aqueous solution of 9-(2-hydroxyethoxymethyl)-guanine in form of a derivative, particularly monophosphate, and an aqueous solution of lactosaminated human albumin are reacted in the presence of 1-ethyl-3-(dimethylaminopropyl)-carbodiimide, by adjusting the pH to the value of 7.5 and by maintaining the reaction mixture for 24 hours under stirring and in the dark.
    Type: Grant
    Filed: October 21, 1986
    Date of Patent: February 16, 1988
    Assignee: Laboratori Baldacci S.p.A.
    Inventors: Massimo Baldacci, Luigi Fiume, Corrado Busi, Alessandro Mattioli