Patents by Inventor Corrado Colli

Corrado Colli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction and novel synthesis intermediates
    Patent number: 11053227
    Abstract: Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: July 6, 2021
    Assignee: OLON S.P.A.
    Inventors: Corrado Colli, Giorgio Bertolini, Mara Sada, Faris Garis, Filippo Nisic, Aldo Bianchi, Cinzia Biaggi, Romano Di Fabio, Silvano Ronzoni, Stefania Bertuolo, Adolfo Prandi, Stefano Maiorana
  • Process for the preparation of a novel umeclidinium synthesis intermediate
    Patent number: 11028082
    Abstract: The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: June 8, 2021
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Filippo Nisic, Mara Sada, Stefania Bertuolo, Silvano Ronzoni, Stefano Maiorana, Romano Di Fabio
  • PROCESS FOR THE SYNTHESIS OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS
    Publication number: 20210061757
    Abstract: Subject-matter of the present invention is a process for the preparation of optically active phenyl-beta-amino alcohols by means of a specific reduction of the corresponding phenyl-beta-amino ketones. Further subject-matter of the invention are said novel synthesis intermediates and their use for the preparation of active pharmaceutical ingredients.
    Type: Application
    Filed: April 11, 2019
    Publication date: March 4, 2021
    Inventors: Filippo NISIC, Faris GARIS, Corrado COLLI, Giorgio BERTOLINI, Mara SADA, Stefania BERTUOLO, Silvano RONZONI, Romano DI FABIO, Stefano MAIORANA
  • PROCESS FOR PREPARING INTERMEDIATES FOR THE SYNTHESIS OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS BY ENZYMATIC REDUCTION AND NOVEL SYNTHESIS INTERMEDIATES
    Publication number: 20200385366
    Abstract: Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.
    Type: Application
    Filed: December 19, 2018
    Publication date: December 10, 2020
    Inventors: Corrado COLLI, Giorgio BERTOLINI, Mara SADA, Faris GARIS, Filippo NISIC, Aldo BIANCHI, Cinzia BIAGGI, Romano DI FABIO, Silvano RONZONI, Stefania BERTUOLO, Adolfo PRANDI, Stefano MAIORANA
  • PROCESS FOR THE PREPARATION OF A NOVEL UMECLIDINIUM SYNTHESIS INTERMEDIATE
    Publication number: 20200102300
    Abstract: The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.
    Type: Application
    Filed: May 28, 2018
    Publication date: April 2, 2020
    Inventors: Giorgio BERTOLINI, Corrado COLLI, Filippo NISIC, Mara SADA, Stefania BERTUOLO, Silvano RONZONI, Stefano MAIORANA, Romano DI FABIO
  • Process for the preparation of indanamine derivatives and new synthesis intermediates
    Patent number: 10538479
    Abstract: Subject-matter of the invention is a process for the preparation of key intermediates in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: January 21, 2020
    Assignee: OLON S.P.A.
    Inventors: Corrado Colli, Alessandro Agosti, Stefano Maiorana, Federica Colombo, Giorgio Bertolini
  • Process for preparing intermediates useful in the synthesis of antifungal drugs
    Patent number: 10487070
    Abstract: Subject-matter of the invention is a process for preparing intermediates useful in the synthesis of drugs, for example antifungal drugs, such as efinaconazole. Subject-matter of the invention are also such novel synthesis intermediates and the use thereof.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 26, 2019
    Assignee: OLSON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Mara Sada, Federica Colombo
  • PROCESS FOR PREPARING INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANTIFUNGAL DRUGS
    Publication number: 20190119244
    Abstract: Subject-matter of the invention is a process for preparing intermediates useful in the synthesis of drugs, for example antifungal drugs, such as efinaconazole. Subject-matter of the invention are also such novel synthesis intermediates and the use thereof.
    Type: Application
    Filed: March 23, 2017
    Publication date: April 25, 2019
    Inventors: Giorgio BERTOLINI, Corrado COLLI, Mara SADA, Federica COLOMBO
  • Process for the preparation of indanamine derivatives and new synthesis intermediates
    Publication number: 20180258028
    Abstract: Subject-matter of the invention is a process for the preparation of key intermediates in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Application
    Filed: September 28, 2016
    Publication date: September 13, 2018
    Inventors: Corrado COLLI, Alessandro AGOSTI, Stefano MAIORANA, Federica COLOMBO, Giorgio BERTOLINI
  • Process for the preparation of indanamine derivatives and new synthesis intermediates
    Patent number: 10059653
    Abstract: Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: August 28, 2018
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Paolangelo Cerea, Corrado Colli, Lazzaro Feliciani, Federico Gassa, Aldo Bianchi, Federica Colombo, Stefano Maiorana, Filippo Nisic
  • Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters
    Patent number: 10023535
    Abstract: The present invention refers to a process for the preparation of 1-(2-halogen-ethyl)-4-piperidinecarboxylic acid ethyl esters, in particular of 1-(2-chloroethyl)-4 piperidinecarboxylic acid ethyl ester, a versatile synthesis intermediate, particularly useful as an intermediate compound in the synthesis of umeclidinium.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: July 17, 2018
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Aldo Bianchi, Federica Colombo, Stefano Maiorana, Filippo Nisic
  • PROCESS FOR THE PREPARATION OF INDANAMINE DERIVATIVES AND NEW SYNTHESIS INTERMEDIATES
    Publication number: 20170362161
    Abstract: Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Application
    Filed: January 19, 2016
    Publication date: December 21, 2017
    Applicant: OLON S.P.A.
    Inventors: Giorgio BERTOLINI, Paolangelo CEREA, Corrado COLLI, Lazzaro FELICIANI, Federico GASSA, Aldo BIANCHI, Federica COLOMBO, Stefano MAIORANA, Filippo NISIC
  • METHOD FOR THE PREPARATION OF 1-(2-HALOGEN-ETHYL)-4 PIPERIDINE-CARBOXYLIC ACID ETHYL ESTERS
    Publication number: 20170313657
    Abstract: The present invention refers to a process for the preparation of 1-(2-halogen-ethyl)-4-piperidinecarboxylic acid ethyl esters, in particular of 1-(2-chloroethyl)-4 piperidinecarboxylic acid ethyl ester, a versatile synthesis intermediate, particularly useful as an intermediate compound in the synthesis of umeclidinium.
    Type: Application
    Filed: October 22, 2015
    Publication date: November 2, 2017
    Applicant: OLON S.P.A.
    Inventors: Giorgio BERTOLINI, Corrado COLLI, Aldo BIANCHI, Federica COLOMBO, Stefano MAIORANA, Filippo NISIC
  • Process for preparing Bosentan monohydrate and it's intermediates
    Patent number: 8933226
    Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: January 13, 2015
    Assignee: Zach Systems S.p.A.
    Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
  • PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATED
    Publication number: 20130253195
    Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
    Type: Application
    Filed: September 22, 2011
    Publication date: September 26, 2013
    Applicant: ZACH SYSTEM SPA
    Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
  • Process for the preparation of levetiracetam
    Patent number: 7939676
    Abstract: A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (?)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: May 10, 2011
    Assignee: Zach System S.p.A.
    Inventors: Corrado Colli, Massimiliano Forcato, Livius Cotarca
  • Process for the preparation of Levetiracetam
    Publication number: 20110065932
    Abstract: A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (?)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.
    Type: Application
    Filed: September 17, 2009
    Publication date: March 17, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Corrado Colli, Massimiliano Forcato, Livius Cotarca
  • Process for the synthesis of modafinil
    Publication number: 20040106829
    Abstract: The present invention relates to a process for the preparation of 2-(benzhydrylthio)acetamide (II), key intermediate for the synthesis of modafinil, by reaction of benzhydryl chloride with thiourea and chloroacetamide.
    Type: Application
    Filed: November 10, 2003
    Publication date: June 3, 2004
    Applicant: PROCOS S.P.A.
    Inventors: Mirco Fornaroli, Francesco Velardi, Corrado Colli, Roberto Baima