Patents by Inventor Corrado Spadafora

Corrado Spadafora has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-nucleosidic inhibitors of reverse transcriptase as antagonists of cell proliferation and inducers of cell differentiation
    Patent number: 10507207
    Abstract: The invention refers to the use of Reverse Transcriptase (RT) inhibitor compounds for the preparation of pharmaceutical compositions to counteract the loss of cellular differentiation in tumour and non tumour pathologies, said compound being able to bind the hydrophobic pocket on the RT subunit p66. Particularly preferred for such uses are the following compounds: nevirapine, efavirenz, delavirdine, corresponding salts and/or pharmaceutically acceptable derivatives thereof.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: December 17, 2019
    Assignee: ISTITUTO SUPERIORE DI SANITA
    Inventors: Corrado Spadafora, Patriźia Ĺavia, Elisabetta Mattei, Gugliemo Palombini, Rodolfo Nello Lorenzini, Clara Nervi
  • Monoclonal antibody to human line-1 ORF2 protein and method for early detection of transforming cells in pre-neoplastic tissues of a human subject
    Patent number: 10214591
    Abstract: The present disclosure relates to a monoclonal antibody specifically binding to human Long Interspersed Element-1 ORF2 encoded protein (L1-ORF2p) obtained from hybridoma chA1, and derivatives and uses thereof, including for prediction of response of cancer patients to NNRTI treatments. It also relates to a method for early detection of cell transformation in pre-neoplastic tissues of a human subject, comprising detecting in cells of a pre-neoplastic tissue sample from said subject the expression of L1-ORF2p, wherein the expression of L1-ORF2p indicates the presence of cell transformation in said pre-neoplastic tissues. It also relates to a method for detecting progression of colon adenoma in a human subject suffering from colon adenoma, based on detection of an increase of L1-ORF2p expression.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: February 26, 2019
    Inventors: Corrado Spadafora, Ilaria Sciamanna, Chiara De Luca, Paola Sinibaldi-Vallebona, Fiorella Guadagni, Gerald Schumann, Enrico Garaci
  • Retrotransposon Inhibition in Therapy
    Publication number: 20090203892
    Abstract: RNA interference is useful in the treatment of cancerous lesions, wherein the RNA recognises a portion of at least one LINE-I repeat element.
    Type: Application
    Filed: December 30, 2005
    Publication date: August 13, 2009
    Applicants: ISTITUTO SUPERIORE DI SANITA
    Inventors: Enrico Garaci, Paola Sinibaldi, Corrado Spadafora, Carmine Pittoggi, Ilaria Sciamanna, Cristina Mearelli
  • Non-nucleosidic inhibitors of reverse transcriptase as antagonists of cell proliferation and inducers of cell differentiation
    Publication number: 20060166970
    Abstract: The invention refers to the use of Reverse Transcriptase (RT) inhibitor compounds for the preparation of pharmaceutical compositions to counteract the loss of cellular differentiation in tumour and non tumour pathologies, said compound being able to bind the hydrophobic pocket on the RT subunit p66. Particularly preferred for such uses are the following compounds: nevirapine, efavirenz, delavirdine, corresponding salts and/or pharmaceutically acceptable derivatives thereof.
    Type: Application
    Filed: December 23, 2002
    Publication date: July 27, 2006
    Inventors: Corrado Spadafora, Patrizia Lavia, Elisabetta Mattei, Gugliemo Palombini, Rodolfo Lorenzini, Clara Nervi
  • RNA transfection of sperm cells
    Publication number: 20040031070
    Abstract: A method is described for transferring expressible foreign genes into multi-cellular organisms by means of RNA uptake by sperm cells, followed by endogenous reverse transcription of RNA into cDNA. cDNA molecules are transferred to embryos through fertilization, and are transmitted to born animals and their progeny. The cDNA sequences are mosaically distributed in the cells and tissue of the organisms, and are preferentially expressed in target tissues.
    Type: Application
    Filed: October 15, 2001
    Publication date: February 12, 2004
    Inventors: Corrado Spadafora, Clague Pitman Hodgson, Rodolfo N. Lorenzini