Patents by Inventor Cortina Kaletta

Cortina Kaletta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective toxin expression in angiogenic endothelial cells
    Publication number: 20030125294
    Abstract: The present invention relates to pharmaceutical compositions capable of specifically inducing cell death in the proliferating angiogenic endothelial cells associated with solid tumors and other angiogenesis associated diseases. More specifically, the present invention relates to nucleotide constructs that are selectively active in angiogenic endothelial cells and that encode highly toxic agents, such as diphtheria toxin, for expression in such cells.
    Type: Application
    Filed: November 15, 2002
    Publication date: July 3, 2003
    Applicant: University Technology Corporation
    Inventors: Ian H. Maxwell, Francoise Maxwell, Cortina Kaletta, Kurt W. Naujoks
  • Method for electrochemiluminescent labeling of nucleic acid, use in detection, and compositions therefor
    Patent number: 6027885
    Abstract: Method for immobilizing nucleic acids by hybridizing the nucleic acid with a capture probe. The capture probe is protected against enzymatic extension and/or enzymatic degradation of the formed hybrid.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: February 22, 2000
    Assignee: Roche Diagnostics GmbH
    Inventors: Cornelia Kruse-Mueller, Sibylle Berner, Cortina Kaletta
  • Biosynthetic process for the preparation of chemical compounds
    Patent number: 5843709
    Abstract: A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described.Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 1, 1998
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Karl-Dieter Entian, Friedrich Gotz, Norbert Schnell, Johannes Augustin, Germar Engelke, Ralf Rosenstein, Cortina Kaletta, Cora Klein, Bernd Wieland, Thomas Kupke, Gunther Jung, Roland Kellner
  • DNA encoding and biosynthetic process for the preparation of chemical compounds, lantibiotics
    Patent number: 5837485
    Abstract: A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described.Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: November 17, 1998
    Assignee: Dr. Karl Tomae GmbH
    Inventors: Karl-Dieter Entian, Friedrich Gotz, Norbert Schnell, Johannes Augustin, Germar Engelke, Ralf Rosenstein, Cortina Kaletta, Cora Klein, Bernd Wieland, Thomas Kupke, Gunther Jung, Roland Kellner
  • Method for immobilizing nucleic acids using modified capture probes
    Patent number: 5639609
    Abstract: Method for immobilizing nucleic acids by hybridizing the nucleic acid with a capture probe. The capture probe is protected against enzymatic extension and/or enzymatic degradation of the formed hybrid.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: June 17, 1997
    Assignee: Boehringer Mannheim GmbH
    Inventors: Cornelia Kruse-Mueller, Sibylle Berner, Cortina Kaletta
  • Promotor controlled specific amplification of nucleic acid sequences
    Patent number: 5474916
    Abstract: Process for the specific production of nucleic acids based on the principle of transcription in which a promoter oligonucleotide and a template-specific oligonucleotide which can hybridize with it are used as a promoter reagent and a process for nucleic acid detection which is based on this process.
    Type: Grant
    Filed: September 28, 1992
    Date of Patent: December 12, 1995
    Assignee: Boehringer Mannheim GmbH
    Inventors: Udo Reischl, Ruediger Rueger, Cortina Kaletta, Christoph Kessler, Joerg Kleiber