Patents by Inventor Corwin Miller

Corwin Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for making selenocysteine containing polypeptides
    Patent number: 10240158
    Abstract: Non-naturally occurring tRNASec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNASec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring tRNASec a recombinant expression system, such as E. coli, with SerRS, EF-Tu, SelA, or PSTK and SepSecS, and an mRNA with at least one codon that recognizes the anticodon of the non-naturally occurring tRNASec.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: March 26, 2019
    Assignee: Yale University
    Inventors: Dieter Soll, Caroline Aldag, Michael Hohn, Corwin Miller
  • Compositions and Methods for Making Selenocysteine Containing Polypeptides
    Publication number: 20170002347
    Abstract: Non-naturally occurring tRNASec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNASec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring tRNASec a recombinant expression system, such as E. coli, with SerRS, EF-Tu, SelA, or PSTK and SepSecS, and an mRNA with at least one codon that recognizes the anticodon of the non-naturally occurring tRNASec.
    Type: Application
    Filed: July 5, 2016
    Publication date: January 5, 2017
    Inventors: Dieter Soll, Caroline Aldag, Michael Hohn, Corwin Miller
  • Method and apparatus for detecting cadmium with optical emission spectroscopy
    Patent number: 9097584
    Abstract: An apparatus and method for detecting cadmium using optical emission spectroscopy is provided. The apparatus contains a system which uses optical emission spectroscopy which is programmed and calibrated to detect the presence of cadmium in PPM. The system is calibrated using test samples which have been prepared with a lead/cadmium matrix material having at least one iron based electrode integrated therein.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: August 4, 2015
    Assignee: LINCOLN GLOBAL, INC.
    Inventors: John Edward McLane, Corwin Miller
  • METHOD AND APPARATUS FOR DETECTING CADMIUM WITH OPTICAL EMISSION SPECTROSCOPY
    Publication number: 20140218728
    Abstract: An apparatus and method for detecting cadmium using optical emission spectroscopy is provided. The apparatus contains a system which uses optical emission spectroscopy which is programmed and calibrated to detect the presence of cadmium in PPM. The system is calibrated using test samples which have been prepared with a lead/cadmium matrix material having at least one iron based electrode integrated therein.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: LINCOLN GLOBAL, INC.
    Inventors: John Edward McLane, Corwin Miller
  • Method and apparatus for detecting cadmium with optical emission spectroscopy
    Patent number: 8730470
    Abstract: An apparatus and method for detecting cadmium using optical emission spectroscopy is provided. The apparatus contains a system which uses optical emission spectroscopy which is programmed and calibrated to detect the presence of cadmium in PPM. The system is calibrated using test samples which have been prepared with a lead/cadmium matrix material having at least one iron based electrode integrated therein.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: May 20, 2014
    Assignee: Lincoln Global, Inc.
    Inventors: John Edward McLane, Corwin Miller
  • METHOD AND APPARATUS FOR DETECTING CADMIUM WITH OPTICAL EMISSION SPECTROSCOPY
    Publication number: 20120013904
    Abstract: An apparatus and method for detecting cadmium using optical emission spectroscopy is provided. The apparatus contains a system which uses optical emission spectroscopy which is programmed and calibrated to detect the presence of cadmium in PPM. The system is calibrated using test samples which have been prepared with a lead/cadmium matrix material having at least one iron based electrode integrated therein.
    Type: Application
    Filed: July 14, 2010
    Publication date: January 19, 2012
    Applicant: LINCOLN GLOBAL, INC.
    Inventors: John Edward McLane, Corwin Miller