Patents by Inventor Cory A Brennick

Cory A Brennick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unbiased identification of tumor rejection mediating neoepitopes
    Patent number: 11920202
    Abstract: Described herein is an unbiased method of identifying tumor rejection mediating neoepitopes (TRMNs). Putative neoepitopes from a cancer cell exome sequence from a cancer patient are putative neoepitopes are unbiased by MHC binding and/or CD8T* reactivity. By plotting the putative neoepitope IC50s on one axis, and the non-mutated amino acid sequence IC50s on a perpendicular axis to provide a bivariate scatter plot, novel TRMNs are identified TRMNs the neoepitopes in the bivariate scatter plot which are in the space greater than 501 nM on the x-axis and greater than 501 nM on the y-axis. Peptides and nucleic acids for expressing peptides including the TRMNs are also described.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: March 5, 2024
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Pramod K. Srivastava, Ion I Mandoiu, Cory A Brennick, Mariam M George, Marmar Moussa
  • UNBIASED IDENTIFICATION OF TUMOR REJECTION MEDIATING NEOEPITOPES
    Publication number: 20210317533
    Abstract: Described herein is an unbiased method of identifying tumor rejection mediating neoepitopes (TRMNs). Putative neoepitopes from a cancer cell exome sequence from a cancer patient are putative neoepitopes are unbiased by MHC binding and/or CD8T* reactivity. By plotting the putative neoepitope IC50s on one axis, and the non-mutated amino acid sequence IC50s on a perpendicular axis to provide a bivariate scatter plot, novel TRMNs are identified TRMNs the neoepitopes in the bivariate scatter plot which are in the space greater than 501 nM on the x-axis and greater than 501 nM on the y-axis. Peptides and nucleic acids for expressing peptides including the TRMNs are also described.
    Type: Application
    Filed: April 8, 2021
    Publication date: October 14, 2021
    Inventors: Pramod K. Srivastava, Ion I Mandoiu, Cory A Brennick, Mariam M George, Marmar Moussa