Patents by Inventor Cory L. Ahonen

Cory L. Ahonen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOSTIMULATORY COMBINATIONS
    Publication number: 20190083592
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Application
    Filed: October 22, 2018
    Publication date: March 21, 2019
    Inventors: Randolph J. NOELLE, Cory L. AHONEN, Ross M. KEDL
  • Immunostimulatory combinations
    Patent number: 10105426
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: October 23, 2018
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Randolph J. Noelle, Cory L. Ahonen, Ross M. Kedl
  • Immunostimulatory Combinations
    Publication number: 20160129095
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Application
    Filed: September 10, 2015
    Publication date: May 12, 2016
    Inventors: Randolph J. NOELLE, Cory L. Ahonen, Ross M. Kedl
  • Immunotherapy comprising TLR9 ligand and CD40 ligand
    Patent number: 9161976
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: October 20, 2015
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Cory L. Ahonen, Ross M. Kedl
  • Method for modulating inflammatory responses
    Patent number: 8679501
    Abstract: The present invention is a method for inhibiting Treg cell functional activities by blocking Treg cell-mediated mast cell activation. It has been found IL-9 produced by Treg cells activates mast cells, which in turn mediate an amplification loop critical for graft tolerance and immune responses to tumors. Thus, a method for enhancing an immune response to a vaccine, such as a cancer vaccine, is also provided as is a method for increasing cell and humoral immunity in a subject.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: March 25, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Cory L. Ahonen
  • USE OF TLR AGONISTS AND/OR TYPE 1 INTERFERONS TO ALLEVIATE TOXICITY OF TNF-R AGONIST THERAPEUTIC REGIMENS
    Publication number: 20130302278
    Abstract: Improved (safer and more effective) methods of therapy using TNF-R agonists, e.g., CD40 agonists are provided. These methods provide for the addition of an amount of a type 1 interferon and/or a TLR agonist that is effective to prevent or reduce the toxicity (liver toxicity) that may otherwise result in some patients of the TNF-R agonist is used as a monotherapy (without the type 1 interferon and/or TLR agonist).
    Type: Application
    Filed: April 16, 2013
    Publication date: November 14, 2013
    Inventors: Randolph J. Noelle, Ross M. Kedl, Cory L. Ahonen
  • Ex vivo uses of immunostimulatory combinations
    Patent number: 8329197
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: December 11, 2012
    Assignees: 3M Innovative Properties Company, Trustees of Dartmouth
    Inventors: Randolph J. Noelle, Cory L. Ahonen, Ross M. Kedl
  • IMMUNOSTIMULATORY COMBINATIONS
    Publication number: 20110280903
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Application
    Filed: June 22, 2011
    Publication date: November 17, 2011
    Inventors: Randolph J. Noelle, Cory L. Ahonen, Ross M. Kedi
  • TLR9 agonist and CD40 agonist immunostimulatory combinations
    Patent number: 7993659
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: August 9, 2011
    Assignees: 3M Innovative Properties Company, Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Cory L. Ahonen, Ross M. Kedl
  • Immunostimulatory Combinations
    Publication number: 20110002946
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Application
    Filed: July 29, 2010
    Publication date: January 6, 2011
    Inventors: Randolph J. Noelle, Cory L. Ahonen, Ross M. Kedi
  • IMMUNOSTIMULATORY COMBINATIONS
    Publication number: 20090123460
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Application
    Filed: March 17, 2008
    Publication date: May 14, 2009
    Applicant: 3M Innovative Properties Company
    Inventors: Randolph J. NOELLE, Cory L. Ahonen, Ross M. Kedl
  • Method for Modulating Inflammatory Responses
    Publication number: 20080220006
    Abstract: The present invention is a method for inhibiting Treg cell functional activities by blocking Treg cell-mediated mast cell activation. It has been found IL-9 produced by Treg cells activates mast cells, which in turn mediate an amplification loop critical for graft tolerance and immune responses to tumors. Thus, a method for enhancing an immune response to a vaccine, such as a cancer vaccine, is also provided as is a method for increasing cell and humoral immunity in a subject.
    Type: Application
    Filed: November 1, 2006
    Publication date: September 11, 2008
    Inventors: Randolph J. Noelle, Li-Fan Lu, Cory L. Ahonen
  • Immunostimulatory combinations
    Patent number: 7387271
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: June 17, 2008
    Assignees: 3M Innovative Properties Company, Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Cory L. Ahonen, Ross M. Kedl
  • Immunostimulatory combinations
    Publication number: 20040141950
    Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
    Type: Application
    Filed: December 30, 2003
    Publication date: July 22, 2004
    Applicant: 3M Innovative Properties Company
    Inventors: Randolph J. Noelle, Cory L. Ahonen, Ross M. Kedl
  • Maturation of dendritic cells with immune response modifying compounds
    Publication number: 20030186440
    Abstract: A method of inducing the maturation of dendritic cells by stimulating immature dendritic cells with an imidazoquinoline type immune response modifying compound. Dendritic cells that have been matured in this manner display increased antigen presenting ability and may be used as immunotherapeutic agents.
    Type: Application
    Filed: January 30, 2003
    Publication date: October 2, 2003
    Applicant: 3M Innovative Properties Company
    Inventors: Mark A. Tomai, John P. Vasilakos, Cory L. Ahonen
  • Maturation of dendritic cells with immune response modifying compounds
    Patent number: 6558951
    Abstract: A method of inducing the maturation of dendritic cells by stimulating immature dendritic cells with an imidazoquinoline type immune response modifying compound. Dendritic cells that have been matured in this manner display increased antigen presenting ability and may be used as immunotherapeutic agents.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: May 6, 2003
    Assignee: 3M Innovative Properties Company
    Inventors: Mark A. Tomai, John P. Vasilakos, Cory L. Ahonen