Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.

Abstract: Provided herein are anti-Trop 2 antibodies or binding fragments thereof that bind Trop 2, e.g., human Trop 2. The anti-Trop 2 antibodies of the disclosure are useful for the treatment of proliferative disorders or cells that express Trop 2 or mutant Trop 2. Also provided herein are methods of use for the anti-Trop 2 antibodies or binding fragments thereof, as well as bi-valent or multi-valent anti-Trop 2 antibodies or binding fragments thereof that may form complexes that attract immune effectors or binding to other cells, such as, a second antibody, antigen-binding of the second antibody or fragment thereof; a target-binding protein, a cytokine; a lectin; or a toxin.

Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.

Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

Abstract: Provided herein are anti-EGFRvII antibodies and binding fragments thereof. The anti-EGFRvIII antibodies of the disclosure are useful for the treatment of cancers through, e.g., antibody-dependent cell cytotoxicity (ADCC). Also provided herein are methods of making and using the anti-EGFRvIII antibodies for the treatment of cancer, and polynucleotides that encode the same.

Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.

Abstract: Systems and methods of transmitting data packets in a live data feed are provided. A live data processing system receives a plurality of tracking data packets that are obtained using radar devices and image capturing devices. The live data processing system determines that a particular tracking data packet is missing from the plurality of tracking data packets based on a predetermined order for receiving the plurality of tracking data packets. The live data processing system queues the plurality of tracking data packets. The live data processing system generates a plurality of message packets based on the plurality of tracking data packets and the particular tracking data packet that is received after receiving the plurality of tracking data packets. The live data processing system transmits, in the live data feed, the plurality of message packets in the predetermined order to a plurality of devices for display.

Abstract: Systems and methods for presenting sports data is provided. A server receives raw game data relating to a sporting event. The server determines whether the raw game data satisfies at least one predefined criterion in a plurality of predefined rules. Responsive to determining that the raw game data satisfies at least one predefined criterion in the plurality of predefined rules, the server generates game commentary data comprising text related to action occurring during the sporting event. The server provides the generated game commentary data to an electronic user device for display.

Abstract: A method for performing pitch classification includes receiving, at a computing device, one or more pitch properties corresponding to a ball thrown by a pitcher. Pitcher information corresponding to the pitcher is also received. The pitcher information includes at least an identification of one or more pitches that are in a repertoire of the pitcher. A classification of the pitch is determined using at least a pitch classification algorithm, where the classification of the pitch is based at least in part on the one or more pitch properties and at least in part on the pitcher information.

Abstract: A method for performing pitch classification includes receiving, at a computing device, one or more pitch properties corresponding to a ball thrown by a pitcher. Pitcher information corresponding to the pitcher is also received. The pitcher information includes at least an identification of one or more pitches that are in a repertoire of the pitcher. A classification of the pitch is determined using at least a pitch classification algorithm, where the classification of the pitch is based at least in part on the one or more pitch properties and at least in part on the pitcher information.

Abstract: A system and method is described for determining a scoring efficiency of a team engaged in a sport, such as baseball, softball or other sport in which runners attempt to advance from a series of base positions. A memory or database stores a total number of runs scored from scoring position and a total number of individual base runners that reached base from a single at-bat, over a predetermined interval, such as an inning, a series of innings, a game or a series of games. A processor, coupled to the memory, determine scoring efficiency by determining a ratio between the number of runs scored from scoring position and the total number of individual base runners that reached base from a single at-bat. An output device operatively connected the processor receives the scoring efficiency calculated by the processor and transmits or displays the scoring efficiency for evaluation of a team's efficiency in scoring from scoring position or preventing scoring from scoring position.

Abstract: A method for performing pitch classification includes receiving, at a computing device, one or more pitch properties corresponding to a ball thrown by a pitcher. Pitcher information corresponding to the pitcher is also received. The pitcher information includes at least an identification of one or more pitches that are in a repertoire of the pitcher. A classification of the pitch is determined using at least a pitch classification algorithm, where the classification of the pitch is based at least in part on the one or more pitch properties and at least in part on the pitcher information.

Abstract: A system and method is described for determining a scoring efficiency of a team engaged in a sport, such as baseball, softball or other sport in which runners attempt to advance from a series of base positions. A memory or database stores a total number of runs scored from scoring position and a total number of individual base runners that reached base from a single at-bat, over a predetermined interval, such as an inning, a series of innings, a game or a series of games. A processor, coupled to the memory, determine scoring efficiency by determining a ratio between the number of runs scored from scoring position and the total number of individual base runners that reached base from a single at-bat. An output device operatively connected the processor receives the scoring efficiency calculated by the processor and transmits or displays the scoring efficiency for evaluation of a team's efficiency in scoring from scoring position or preventing scoring from scoring position.