Patents by Inventor Costas N. Karatzas

Costas N. Karatzas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of collagen in the milk of transgenic mammals
    Publication number: 20100305039
    Abstract: The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided.
    Type: Application
    Filed: November 10, 2008
    Publication date: December 2, 2010
    Applicants: Pharming Intellectual Property B.V., Cohesion Technologies, Inc.
    Inventors: Costas N. Karatzas, Frank Pieper, Ineke De Wit, Richard Berg, Gerard Platenburg, Paul David Toman
  • Production of biofilaments in transgenic animals
    Patent number: 7157615
    Abstract: Disclosed is a method for the recombinant production of biofilaments, such as spider silk or insect fibroins, using transgenic animals which secrete the biofilaments in their milk and/or urine, and transgenic cells which secrete the biofilaments into culture media. Such a method is useful for producing large quantities of biofilament material. Also disclosed is a nucleic acid molecule for generating such transgenic animals.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: January 2, 2007
    Assignee: Nexia Biotechnologies, Inc.
    Inventors: Costas N. Karatzas, Jeffrey D. Turner, Anthoula Lazaris-Karatzas
  • Production of collagen in the milk of transgenic mammals
    Patent number: 6713662
    Abstract: The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 30, 2004
    Assignees: Pharming Intellectual Property B.V., Cohesion Technologies
    Inventors: Costas N. Karatzas, Frank Pieper, Ineke De Wit, Richard Berg, Gerard Platenburg, Paul David Toman
  • Production of butyrylcholinesterases in transgenic mammals
    Publication number: 20040016005
    Abstract: The present invention provides methods for the large-scale production of recombinant butyrylcholinesterase in cell culture, and in the milk and/or urine of transgenic mammals. The recombinant butyrylcholinesterases of this invention can be used to treat and/or prevent organophosphate pesticide poisoning, nerve gas poisoning, cocaine intoxication, and succinylcholine-induced apnea.
    Type: Application
    Filed: December 20, 2002
    Publication date: January 22, 2004
    Inventors: Costas N. Karatzas, Yue-Jin Huang, Anthoula Lazaris
  • PRODUCTION OF BIOFILAMENTS IN TRANSGENIC ANIMALS
    Publication number: 20010042255
    Abstract: Disclosed is a method for the recombinant production of biofilaments, such as spider silk or insect fibroins, using transgenic animals which secrete the biofilaments in their milk and/or urine, and transgenic cells which secrete the biofilaments into culture media. Such a method is useful for producing large quantities of biofilament material. Also disclosed is a nucleic acid molecule for generating such transgenic animals.
    Type: Application
    Filed: March 17, 1998
    Publication date: November 15, 2001
    Inventors: COSTAS N. KARATZAS, JEFFREY D. TURNER, ANTHOULA LAZARIS KARATZAS
  • Aspergillus niger beta-galactosidase gene
    Patent number: 5821350
    Abstract: Disclosed are a cloned cDNA and a cloned genomic DNA, both encoding a .beta.-galactosidase polypeptide from Aspergillus niger. Also disclosed are .beta.-galactosidase expression vectors, transformed host cells that overexpress recombinant A. niger .beta.-galactosidase, and A. niger host cell strains with disrupted endogenous .beta.-galactosidase genes. Also disclosed are transgenic non-human mammals that express A. niger .beta.-galactosidase.
    Type: Grant
    Filed: November 1, 1995
    Date of Patent: October 13, 1998
    Assignee: Nexia Biotechnologies, Inc.
    Inventors: Yue Huang, Costas N. Karatzas, Anthoula Lazaris-Karatzas, Annick Delaquis