Abstract: A novel packaging for flat media having substantially square panels wherein at least one of the panels is adapted to form a compartment for storing a phonographic record, an audiovisual record or any flat media. The arrangement of the square panels enables the package to be folded in a compact, flat configuration for ease of storage and shipping. When erected, the package forms a cube that could be used as additional storage. The cube may be erected with either of the sides of the panels visible so as to afford greater opportunity for display.

Abstract: A novel packaging for flat media having substantially square panels wherein at least one of the panels is adapted to form a compartment for storing a phonographic record, an audiovisual record or any flat media. The arrangement of the square panels enables the package to be folded in a compact, flat configuration for ease of storage and shipping. When erected, the package forms a cube that could be used as additional storage. The cube may be erected with either of the sides of the panels visible so as to afford greater opportunity for display.

Abstract: Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extracellular matrix components, type II collagen and sulfated proteoglycans. The proliferated cells then are seeded into a pre-shaped well having a cell contacting, cell abhesive surface. The cells cultured in the well redifferentiate and begin to secrete cartilage-specific extracellular matrix again. Accordingly, essentially unlimited amounts of synthetic cartilage may be prepared from small samples of biopsy tissue. Also provided are methods for surgically repairing articular cartilage defects in mammals using the synthetic cartilage prepared in accordance with the invention.

Abstract: Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extracellular matrix components, type II collagen and sulfated proteoglycans. The proliferated cells then are seeded into a pre-shaped well having a cell contacting, cell abhesive surface. The cells cultured in the well redifferentiate and begin to secrete cartilage-specific extracellular matrix again. Accordingly, essentially unlimited amounts of synthetic cartilage may be prepared from small samples of biopsy tissue. Also provided are methods for surgically repairing articular cartilage defects in mammals using the synthetic cartilage prepared in accordance with the invention.