Abstract: The present disclosure relates generally to the treatment of subjects having endometriosis or at risk of developing endometriosis by administering an R-spondin 3 (RSPO3) inhibitor and/or an RSPO3 Receptor blocker to the subject.

Abstract: A method for taking medically precise measurements with amulti-touch input surface 206 having the steps of displaying, by a graphical user interface: a first point 101 on an ultrasound image 103, wherein the first point 101 is configured to translate with two dimensions of translational freedom upon actuation by a user, and a floating magnification window 102, wherein displaying the floating magnification window 102 comprises calculating a frame based on the first point 101, a size of an area of magnification, a set of dimensions of the multi-touch input surface 206, wherein the frame is configured to crop a copy 104 of the ultrasound image 103.

Abstract: A method for taking medically precise measurements with a multi-touch input surface 206 having the steps of displaying, by a graphical user interface: a first point 101 on an ultrasound image 103, wherein the first point 101 is configured to translate with two dimensions of translational freedom upon actuation by a user, and a floating magnification window 102, wherein displaying the floating magnification window 102 comprises calculating a square frame based on the first point 101, a size of an area of magnification, a width of the multi-touch input surface 206, and a height of the multi-touch input surface 206, wherein the square frame is configured to crop a copy 104 of the ultrasound image 103.

Abstract: A method for taking medically precise measurements with a multi-touch input surface 206 having the steps of displaying, by a graphical user interface: a first point 101 on an ultrasound image 103, wherein the first point 101 is configured to translate with two dimensions of translational freedom upon actuation by a user, and a floating magnification window 102, wherein displaying the floating magnification window 102 comprises calculating a square frame based on the first point 101, a size of an area of magnification, a width of the multi-touch input surface 206, and a height of the multi-touch input surface 206, wherein the square frame is configured to crop a copy 104 of the ultrasound image 103.

Abstract: An engine combustion air pre-cleaner includes a body shaped for effecting cyclonic air flow between an inlet and an outlet of the body. Located along a longitudinal axis of the body is a conical throttling member which is coupled to a control device which operates in response to increasing engine load, as represented by increasing boost pressure, torque and/or speed, to shift the throttling member so as to cause an increasing air flow with increasing engine load.

Abstract: An engine combustion air pre-cleaner includes a body shaped for effecting cyclonic air flow between an inlet and an outlet of the body. Located along a longitudinal axis of the body is a conical throttling member which is coupled to a control device which operates in response to increasing engine load, as represented by increasing boost pressure, torque and/or speed, to shift the throttling member so as to cause an increasing air flow with increasing engine load.

Abstract: A method of decompressing a facet joint comprises forming an opening in a facet capsule of the facet joint and inserting a spacer device through the opening into the facet capsule.

Abstract: A system for augmenting a spinal joint comprises a first flexible stabilizing device adapted to extend through a pedicle of a first vertebra, at least a portion of a vertebral body of the first vertebra, at least a portion of a vertebral body of a second vertebra, and a pedicle of the second vertebra.

Abstract: An intervertebral disc space preparation guide comprises a first member and a second member. The first member includes a first spacer portion adapted for insertion in an intervertebral disc space and a first cutting block portion through which a first bore extends. The second member includes a second spacer portion adapted for insertion in an intervertebral disc space and a second cutting block portion through which a second bore extends. The first member is movably connected to the second member.

Abstract: An intervertebral disc space preparation guide comprises a spacer portion having a first recess and a first machining guide comprising a first bore. The first bore and the first recess are aligned and adapted to receive a first bone removal mechanism.

Abstract: An intervertebral device comprises a first endplate assembly including a first exterior surface, a second endplate assembly including a second exterior surface, and a bone in-growth area located on the first exterior surface. The bone in-growth area includes an osteoconductive surface. The intervertebral device also comprises a bone in-growth indicator located on the first exterior surface and an access guide on the first endplate. The access guide is adapted for directing a revision instrument to the bone in-growth area.

Abstract: Instrumentation and techniques for preparing vertebral members for insertion of an implant. Foundation instruments provide a reference relative to the vertebral members. The foundation devices guide the placement of one or more instruments that prepare the vertebral members. The instruments operatively align with the foundation instruments in a specific orientation to ensure proper placement relative to the vertebral members. Preparatory instruments may be used to further remove bone from the vertebral members. The preparatory instruments may be used prior to or after the other instruments. An insert is inserted and mounted to the vertebral members after the bone has been removed. A holder may be used for holding and placing the implant relative to the vertebral members.