Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A tapered tool holder fixture for installing a retention knob into a tool holder and to determine whether the retention knob has produced distortions in a tool holder surface. A support stand supports a test gauge assembly that includes a mounting ring to which a tool holder is clamped, a gauge portion for receiving a tool holder surface and a camming ring for moving the gauge portion into and out of engagement with the tool holder surface. The mounting ring, camming ring and gauge portion are held together by bolts which allow the relative movement between the gauge portion and a tool holder held by the mounting ring and allow relative rotation between the camming and mounting rings whereby a rotatable detent arrangement moves the gauge portion towards and away from the tool holder. An indicator monitors the position of the gauge portion in order to detect distortions.

Abstract: An apparatus and method for refinishing a tapered surface of a machine tool component. The apparatus includes a head defining at least three tapered segments which are configured to conform precisely to the taper of the machine tool component being refinished. Each segment includes a surface for receiving an abrasive strip, the surfaces configured to conform and confront a conical surface of a taper to be refinished. The head is adapted to engage the tapered surface of the machine tool component so that upon rotation of the head, the abrasive strips abrade the conical surface of the component. A head for refinishing a spindle bore includes three outwardly extending segments whereas the head for refinishing a tool holder shank surface includes three segments extending between annular portions, each segment having an inner tapered surface for receiving the abrasive strips.

Abstract: A tapered tool holder fixture assembly for facilitating the installation of a retention knob into a tool holder and to determine whether the installation of a retention knob has produced distortions in a tapered tool holder surface. A support stand supports a test gauge assembly that includes a mounting ring to which a tool holder is clamped, a gauge portion for receiving a tool holder tapered surface and a camming ring for moving the gauge portion into an out of engagement with the tool holder tapered surface. The mounting ring, camming ring and gauging portion are held together by a plurality of longitudinally extending bolts which allow the relative movement between the gauge portion and a tool holder held by the mounting ring and further allows relative rotation between the camming ring and the mounting ring whereby a rotatable detent arrangement moves the gauging portion towards and away from the tool holder.

Abstract: An apparatus and method for refinishing a tapered surface of a machine tool component. The apparatus includes a head defining at least three tapered segments which are configured to conform precisely to the taper of the machine tool component being refinished. Each segment includes a surface for receiving an abrasive strip, the surfaces configured to conform and confront a conical surface of a taper to be refinished. The head is adapted to engage the tapered surface of the machine tool component so that upon rotation of the head, the abrasive strips abrade the conical surface of the component. A head for refinishing a spindle bore includes three outwardly extending segments whereas the head for refinishing a tool holder shank surface includes three segments extending between annular portions, each segment having an inner tapered surface for receiving the abrasive strips.

Abstract: An actuatable fastener (50) includes a body (80) including a head (82) and a shank (84). The body (80) includes an interior chamber (120) partially defined by a side wall (132) extending from the head (82) into the shank (84) and an end wall (138) positioned in the shank. A member (140) is disposed in the chamber (120). An initiator (160) is actuatable to produce combustion products in the chamber (120) that act on the member (140) to move the member in a first direction in the chamber to strike the end wall (138). The member (140) strikes the end wall (138) creating a fracture (222) in the shank (84) separating at least a portion of the shank from a remainder (220) of the shank. The combustion products moving the member (150) beyond the fracture (222) at least a predetermined distance (226) to move the portion of the shank (84) at least the predetermined distance from the remainder (220) of the shank.

Abstract: An inflator (14) includes a structure (20) that helps define a chamber (30) for containing a volume of inflation fluid (32). A closure member (90) is openable to provide fluid communication between the chamber (30) and an exterior of the inflator (14). A stamped end cap (100) is connectable with the structure (20) to help close the chamber (30). The end cap (100) is made of a steel plate material and has a stamped initiator support portion (112). The initiator support portion (112) has a passage (116) that extends through the end cap (100). An initiator (114) is supported in the initiator support portion (112) of the end cap (100).

Abstract: A shielded radioactive medical apparatus has a tubular housing with a quick release cap configured for closing an open end of the tubular housing. A quick release mechanism holds the quick release cap on an open end of the tubular housing. A data display module on the housing communicates with an outside computer for receiving and transmitting information. The data display model also calculates and displays the radioactivity of a dose within the housing.

Abstract: An actuatable fastener (50) includes a body (80) including a head (82) and a shank (84). The body (80) includes an interior chamber (120) partially defined by a side wall (132) extending from the head (82) into the shank (84) and an end wall (138) positioned in the shank. A member (140) is disposed in the chamber (120). An initiator (160) is actuatable to produce combustion products in the chamber (120) that act on the member (140) to move the member in a first direction in the chamber to strike the end wall (138). The member (140) strikes the end wall (138) creating a fracture (222) in the shank (84) separating at least a portion of the shank from a remainder (220) of the shank. The combustion products moving the member (150) beyond the fracture (222) at least a predetermined distance (226) to move the portion of the shank (84) at least the predetermined distance from the remainder (220) of the shank.

Abstract: A notebook computer (100) or other electronic device has a keyboard (106) using keys (40, 80) which can assume an active state for typing while a spring (64, 84) is pressed against a guide mechanism (44). By disengaging the spring (64, 84) from the guide mechanism, the keys (40, 80) assume a storage state at a lower height.

Abstract: Method and apparatus are disclosed for depositing a uniform layer of material, such as titanium dioxide, on the surface of an object, such as a silicon sphere of a solar array (7). Component gases are injected at predetermined rates into a heated reaction chamber (5) where they react. Because of the reaction rate and injection velocities of the gases, the reaction is substantially completed at a calculated location inside the reaction chamber (5). The object which is to receive the layer, such as the solar array (7), is placed at the calculated location in the reaction chamber (5). The platform (68) to which the solar array (7) is attached is simultaneously tilted and rotated such that all areas of the surface of the array (7) are uniformly exposed to the titanium dioxide reactant.

Abstract: The ASTM E84 flamespread of fibrous products such as hardboard is reduced by incorporation of a combination of alumina trihydrate and a source of B.sub.2 O.sub.3, such as boric acid. The B.sub.2 O.sub.3 source should be capable of providing B.sub.2 O.sub.3 at a temperature below 400.degree. C.