Patents by Inventor Craig A. Hokanson

Craig A. Hokanson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FIBRONECTIN BINDING DOMAIN CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOF
    Publication number: 20220002384
    Abstract: Provided herein are chimeric antigen receptors (CARs) for binding with a target antigen, comprising at least one antigen specific targeting region comprising a fibronectin type 3 (FN3) domain polypeptide. Provided herein are multispecific chimeric antigen receptors for binding with two or more target antigens, comprising at least two antigen specific targeting regions comprising a fibronectin type 3 domain polypeptide. Also provided herein are compositions and methods of treatment relating to the use of subject CARs of the invention.
    Type: Application
    Filed: June 15, 2018
    Publication date: January 6, 2022
    Inventors: Roberto CREA, Jun YOON, Craig A. HOKANSON, Emanuela ZACCO
  • UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES
    Publication number: 20170253645
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Application
    Filed: February 15, 2017
    Publication date: September 7, 2017
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin type III binding-domain libraries
    Patent number: 9376483
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: June 28, 2016
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES
    Publication number: 20140206576
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 24, 2014
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES
    Publication number: 20140135474
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 15, 2014
    Applicant: PROTELICA, INC.
    Inventors: Guido Cappuccilli, Robert Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin type III binding-domain libraries
    Patent number: 8697608
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: April 15, 2014
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin Type III binding-domain libraries
    Patent number: 8680019
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: March 25, 2014
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin type III binding-domain libraries
    Patent number: 8470966
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: June 25, 2013
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES
    Publication number: 20110124527
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Application
    Filed: August 4, 2010
    Publication date: May 26, 2011
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES
    Publication number: 20110021746
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having hign binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Application
    Filed: June 21, 2010
    Publication date: January 27, 2011
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES
    Publication number: 20100152063
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Application
    Filed: September 18, 2009
    Publication date: June 17, 2010
    Applicant: ProtElix, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin type III binding-domain libraries
    Publication number: 20090176654
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Application
    Filed: August 11, 2008
    Publication date: July 9, 2009
    Applicant: ProtElix, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Rho Antibody And Tag To Purify Cell Surface Proteins
    Publication number: 20080097084
    Abstract: A process for the expression and purification of membrane associated proteins is provided. A process for the expression and purification of membrane proteins such as G-protein coupled receptors is provided. A hybrid polypeptide is constructed from a protein of interest and a peptide tag from the amino-terminus extracellular domain of rhodopsin. A method for purifying the hybrid protein using the rhodopsin tag is provided. Methods of detecting the expressed hybrid are also provided.
    Type: Application
    Filed: September 27, 2004
    Publication date: April 24, 2008
    Inventors: Michael J. Mendez, Craig Behnke, Craig Hokanson