Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: A method of determining a diameter of a sheath of an optic nerve includes obtaining, by a processor, scan data representative of the optic nerve sheath, analyzing, by the processor, the scan data to find a position of a globe-optic nerve interface point, segmenting, by the processor, the scan data, processing, by the processor, the segmented scan data at an offset from the position of the globe-optic nerve interface point to determine boundary positions of the optic nerve sheath, and calculating, by the processor, the diameter of the optic nerve sheath based on the determined boundary positions.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

Abstract: There is provided a laser dazzle simulator system, comprising a video camera (20), a processor (50), and a display (60). The processor (50) is configured to receive video of a scene from the video camera (20); superimpose an influence of a laser (LSR) upon the video to simulate a view of the scene that a human would see if the human was viewing the scene whilst having the laser directed into their eyes; and output the simulated view to the display.

Abstract: There is provided a laser event recorder (100) comprising an image sensor, a processing unit coupled to the image sensor, and a wireless transceiver coupled to the processing unit. The processing unit is configured to identify when the image sensor is illuminated by a laser (16); in response to the identification, record a laser event comprising at least one characteristic feature of the laser (16); and send the recorded laser event to a central server (300) using the wireless transceiver. There is further provided an application software for configuring a smartphone as the laser event recorder, and a laser event recording system comprising the laser event recorder and the central server.

Abstract: A method and system for acquiring seismic data from a seismic survey plan is provided. A survey area is selected in which the seismic data will be acquired. A coordinate for at least one point of interest within the survey area is determined and input into a portable navigation device. A navigation solution is determined between a GPS-determined location of the portable navigation device and the determined coordinate and thereupon presented in a human cognizable media. A seismic device may be positioned at the determined coordinate to insonify a subterranean formation with seismic energy or for detecting reflected seismic energy. Data may be periodically entered into and retrieved from the portable navigation device by an in-field operator. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure.

Abstract: The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-?-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-?-carboline compounds.

Abstract: Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).

Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the e//i method comprises the steps of in order: a thiosulfonic acid formation (TSAF) as illustrated below, wherein the reaction is carried out in the presence of a thio sulfate and an oxidizing agent that is or comprises persulfate an oxidative coupling (OC); and a ring closure (RC). The resulting compounds and compositions comprising them (e.g., tablets, capsules) are useful in methods of medical treatment and diagnosis, etc., for example, tauopathies, or Alzheimer's disease (AD).

Abstract: The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-?-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-?-carboline compounds.

Abstract: A method and system for acquiring seismic data from a seismic survey plan is provided. A survey area is selected in which the seismic data will be acquired. A coordinate for at least one point of interest within the survey area is determined and input into a portable navigation device. A navigation solution is determined between a GPS-determined location of the portable navigation device and the determined coordinate and thereupon presented in a human cognizable media. A seismic device may be positioned at the determined coordinate to insonify a subterranean formation with seismic energy or for detecting reflected seismic energy. Data may be periodically entered into and retrieved from the portable navigation device by an in-field operator. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure.

Abstract: A racket toy for launching a ball includes a handle and a rim connected to the handle. The rim defines a central opening. A drumhead material covers the central opening. An arm is connected to the rim and extends towards a center of the central opening. A ball holder cup is positioned on the arm and features a central aperture sized to receive and hold a projectile ball by friction in contact with a front side of the drumhead material. A launching ball attached to the rim by an elastic strap in proximity to a back side of the drumhead material so that said launching ball may be pulled away from the back side of the drumhead material so as place the elastic strap in tension. When the launching ball is released, it strikes the back side of the drumhead material which causes the front side of the drumhead material to launch the projectile ball positioned in the ball bolder cup. The drumhead material produces a sound when it is struck by the launching ball.

Abstract: The present invention provides a barbecue (100) having an outer cabinet (1) which is adapted to fit into a bench top via hole in said bench, said cabinet (1) having an upper periphery adapted to engage an upper surface of said bench, said barbecue including along at least a portion of one side a trough (26) which extends downwardly from said upper periphery, said barbecue (100) having a wall (8) separating said trough (26) from a combustion chamber (2.2) wherein there is located at least one burner (2), whereby said wall (8) includes a viewing panel (8.3, 8.4) so that an operator standing close to said one side can view flame on said burner (2) through said trough (26) and said panel (8.3, 8.4). The present invention also provides a lid (200), a hotplate or griddle (12) and a grease collection system with a removable grease collector (11) which extends along at least a part of a forward edge of the hotplate (12) or grille (1325) so as to receive grease or liquid or other substances therefrom.