Patents by Inventor Craig B. Thompson

Craig B. Thompson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210077529
    Abstract: The present invention provides methods for the induction and monitoring of T cell exhaustion in vitro. The methods are effective for both human and non-human T cells, and for both antigen-specific and polyclonal T cells. The present invention also provides methods to screen for and/or evaluate pharmacologic agents that can either induce or reverse T cell exhaustion. The present invention also provides certain agents that can reverse T cell exhaustion.
    Type: Application
    Filed: April 16, 2019
    Publication date: March 18, 2021
    Inventors: Santosha Vardhana, Lydia Whitney Stillman Finley, Craig B. Thompson
  • Publication number: 20200032315
    Abstract: The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
    Type: Application
    Filed: June 25, 2019
    Publication date: January 30, 2020
    Inventors: Andrew M. Intlekofer, Craig B. Thompson
  • Patent number: 10450596
    Abstract: The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: October 22, 2019
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Andrew M. Intlekofer, Craig B. Thompson
  • Publication number: 20190209503
    Abstract: Methods and compositions for treating cancer and other disorders associated with undesired cellular proliferation are provided comprising administering to a subject in need thereof an amino acid mixture, wherein the amino acid mixture comprises glycine, optionally comprising at least a 2:1 molar ratio of glycine to serine.
    Type: Application
    Filed: March 12, 2019
    Publication date: July 11, 2019
    Inventors: Joshua D. Rabinowitz, Craig B. Thompson, Jiangbin Ye, Jing Fan, Jurre Kamphorst
  • Publication number: 20180140584
    Abstract: Disclosed herein are compositions and methods for detecting and treating cancer. In some embodiments, the cancer is characterized by activation of Ras.
    Type: Application
    Filed: May 13, 2016
    Publication date: May 24, 2018
    Applicants: Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
    Inventors: Craig B. Thompson, Wilhelm Palm
  • Publication number: 20180030502
    Abstract: Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to suc an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. Pharmaceutical compositions and kits comprising that renders the cancer incapable of glycolysis and an autophagy inhibit are also disclosed. Methods of treating an individual who has a disease characterized b cell degeneration and cell death due to autophagy are disclosed. The methods comprise administering to the individual a permeable form of a metabolic substrate that can be oxidized in the tricarboxylic acid cycle to produce NADH. Methods for identifying an autophagy inhibitor comprising performing a test assay using an apopto sis-resistant cell are disclosed.
    Type: Application
    Filed: March 1, 2017
    Publication date: February 1, 2018
    Inventors: Craig B. Thompson, Julian Lum, Daniel Bauer
  • Publication number: 20170175164
    Abstract: The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
    Type: Application
    Filed: March 27, 2015
    Publication date: June 22, 2017
    Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Andrew M. INTLEKOFER, Craig B. THOMPSON
  • Publication number: 20170022475
    Abstract: Disclosed herein are compositions, systems, and methods for modulating proliferation, differentiation and pluripotency of cells.
    Type: Application
    Filed: April 7, 2015
    Publication date: January 26, 2017
    Applicant: Memorial Sloan Kettering Cancer Center
    Inventors: Lydia W.S. FINLEY, Bryce W. CAREY, Craig B. THOMPSON, C. David ALLIS
  • Publication number: 20160374971
    Abstract: Methods and compositions for treating cancer and other disorders associated with undesired cellular proliferation are provided comprising administering to a subject in need thereof an amino acid mixture, wherein the amino acid mixture comprises glycine, optionally comprising at least a 2:1 molar ratio of glycine to serine.
    Type: Application
    Filed: July 1, 2014
    Publication date: December 29, 2016
    Inventors: Joshua D. Rabinowitz, Craig B. Thompson, Jianbin Ye, Jing Fan, Jurre Kamphorst
  • Publication number: 20160033533
    Abstract: The present invention provides biomarkers for sensitive, specific, accurate and quantitative diagnosis and assessment of chronic hypoxia. In particular, the present invention provides 2-hydroxyglutarate as a biomarker that is differentially produced in chronic hypoxia. Furthermore, embodiments of the invention are able to differentiate between chronic and acute hypoxia. Assays for levels of 2-hydroxyglutarate may be used alone or in conjunction with additional biomarkers of hypoxia to increase the precision of analysis. In particular embodiments of the invention, the level of 2-hydroxyglutarate and at least one second biomarker may be assayed to generate a hypoxic profile that can be compared to a reference or control profile, thereby diagnosing a subject as normoxic, chronically hypoxic, or acutely hypoxic.
    Type: Application
    Filed: November 28, 2012
    Publication date: February 4, 2016
    Inventors: David R. Wise, Patrick S. Ward, Craig B. Thompson
  • Patent number: 9060993
    Abstract: Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tri-carboxylate transporter inhibitor are disclosed. of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: June 23, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Craig B. Thompson, Daniel Bauer, Georgia Hatzivassiliou
  • Publication number: 20140314728
    Abstract: The present invention provides biomarkers for sensitive, specific, accurate and quantitative diagnosis and assessment of chronic hypoxia. In particular, the present invention provides 2-hydroxyglutarate as a biomarker that is differentially produced in chronic hypoxia. Furthermore, embodiments of the invention are able to differentiate between chronic and acute hypoxia. Assays for levels of 2-hydroxyglutarate may be used alone or in conjunction with additional biomarkers of hypoxia to increase the precision of analysis. In particular embodiments of the invention, the level of 2-hydroxyglutarate and at least one second biomarker may be assayed to generate a hypoxic profile that can be compared to a reference or control profile, thereby diagnosing a subject as normoxic, chronically hypoxic, or acutely hypoxic.
    Type: Application
    Filed: November 18, 2012
    Publication date: October 23, 2014
    Inventors: David R. Wise, Patrick S. Ward, Craig B. Thompson
  • Patent number: 8747809
    Abstract: The present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as methods of using the single diastereomers of radiolabeled 4-fluoroglutamine as imaging agent is also described.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: June 10, 2014
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Hank F. Kung, Craig B. Thompson, Wenchao Qu, Karl Ploessl
  • Patent number: 8716307
    Abstract: The present invention is directed to methods of using a sirolimus drug and chloroquine or a quinoline derivative in combination. Methods of use are also described.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: May 6, 2014
    Assignee: The Trustees Of The University of Pennsylvania
    Inventors: Ravi Kumar Amaravadi, Craig B. Thompson
  • Patent number: 8574829
    Abstract: Methods of using phenformin to treat certain types of cancers are described.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: November 5, 2013
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Craig B. Thompson, Roland Knoblauch
  • Patent number: 8389276
    Abstract: The present invention relates to a composition comprising an immortalized cell line which is deficient in the expression of one or more gene(s) of the intrinsic apoptotic pathway, selected from the group consisting of Bax, Bak, and mixtures thereof. The present invention further relates to the product of a process for producing an immortalized mouse fibroblast cell line which is deficient in the expression of Bax, Bak, and mixtures thereof. Finally, the present invention relates to a method and a kit for identifying a compound or composition which induces or blocks the extrinsic apoptotic pathway.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: March 5, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Wei-Xing Zong, Craig B. Thompson, Tullia Lindsten
  • Publication number: 20120288444
    Abstract: The present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as methods of using the single diastereomers of radiolabeled 4-fluoroglutamine as imaging agent is also described.
    Type: Application
    Filed: August 13, 2010
    Publication date: November 15, 2012
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Hank F. Kung, Craig B. Thompson, Wenchao Qu, Karl Ploessl
  • Patent number: 8304182
    Abstract: The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: November 6, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Craig B Thompson, Wei-Xing Zong
  • Publication number: 20120129810
    Abstract: The present invention is directed to methods of using a sirolimus drug and chloroquine or a quinoline derivative in combination. Methods of use are also described.
    Type: Application
    Filed: May 4, 2010
    Publication date: May 24, 2012
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Ravi Kumar Amaravadi, Craig B. Thompson
  • Publication number: 20120114676
    Abstract: Methods of using phenformin to treat certain types of cancers are described.
    Type: Application
    Filed: March 30, 2010
    Publication date: May 10, 2012
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Craig B. Thompson, Roland Knoblauch