Patents by Inventor Craig Bates

Craig Bates has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
    Patent number: 10766868
    Abstract: The present application relates to methods of preparing Compound A: or a salt thereof, and a polymorph of Compound A dihydrochloride salt:
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: September 8, 2020
    Assignee: ArQule, Inc.
    Inventors: Craig Bates, Jianmin Mao, David P. Reed
  • Solid forms of substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds
    Patent number: 10717710
    Abstract: The present application provides solid forms of (R)-6-(2-fluorophenyl)-N-(3-(2-(2-methoxyethylamino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine dihydrochloride, and methods of preparing and using same.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: July 21, 2020
    Assignee: ArQule, Inc.
    Inventors: Craig Bates, David P. Reed
  • SOLID FORMS OF TETRAHYDROPYRANYL AMINO-PYRROLOPYRIMIDINONE COMPOUNDS
    Publication number: 20200140442
    Abstract: The present application provides solid forms of (2-chloro-4-phenoxyphenyl)(4-(((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone free base, and methods of preparing and using the same.
    Type: Application
    Filed: August 13, 2019
    Publication date: May 7, 2020
    Inventors: Craig BATES, Erika VOLCKOVA
  • METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE
    Publication number: 20200102276
    Abstract: The present application relates to methods of preparing Compound A: or a salt thereof, and a polymorph of Compound A dihydrochloride salt:
    Type: Application
    Filed: October 3, 2019
    Publication date: April 2, 2020
    Inventors: Craig BATES, Jianmin MAO, David P. REED
  • SOLID FORMS OF SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
    Publication number: 20200002293
    Abstract: The present application provides solid forms of (R)-6-(2-fluorophenyl)-N-(3-(2-(2-methoxyethylamino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine dihydrochloride, and methods of preparing and using same.
    Type: Application
    Filed: January 30, 2019
    Publication date: January 2, 2020
    Inventors: Craig BATES, David P. REED
  • AMINO-PYRROLOPYRIMIDINONE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20190358233
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 28, 2019
    Inventors: Craig BATES, Sudharshan Eathiraj, Hiroaki Inagaki, Jean-Marc Lapierre, Takayuki Momose, Kiyoshi Nakayama, Takashi Odagiri, Masahiro Ota, Yusuke Ota, Yoshihiro Shibata, Manish Tandon, Tomoyuki Tsunemi
  • METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE
    Publication number: 20190241527
    Abstract: The present application relates to methods of preparing Compound A: or a salt thereof, and a polymorph of Compound A dihydrochloride salt:
    Type: Application
    Filed: April 22, 2019
    Publication date: August 8, 2019
    Inventors: Craig BATES, Jianmin MAO, David P. REED
  • Solid forms of substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds
    Patent number: 10227311
    Abstract: The present application provides solid forms of (R)-6-(2-fluorophenyl)-N-(3-(2-(2-methoxyethylamino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine dihydrochloride, and methods of preparing and using same.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: March 12, 2019
    Assignee: ArQule, Inc.
    Inventors: Craig Bates, David P. Reed
  • Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine
    Patent number: 10093632
    Abstract: The present application relates to methods of preparing Compound A: or a salt thereof, and a polymorph of Compound A dihydrochloride salt:
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: October 9, 2018
    Assignee: ArQule, Inc.
    Inventors: Craig Bates, Jianmin Mao, David P. Reed
  • SOLID FORMS OF SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
    Publication number: 20180258055
    Abstract: The present application provides solid forms of (R)-6-(2-fluorophenyl)-N-(3-(2-(2-methoxyethylamino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine dihydrochloride, and methods of preparing and using same.
    Type: Application
    Filed: April 30, 2018
    Publication date: September 13, 2018
    Inventors: Craig BATES, David P. REED
  • Solid forms of substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds
    Patent number: 9981921
    Abstract: The present application provides solid forms of (R)-6-(2-fluorophenyl)-N-(3-(2-(2-methoxyethylamino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine dihydrochloride, and methods of preparing and using same.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: May 29, 2018
    Assignee: ArQule, Inc.
    Inventors: Craig Bates, David P. Reed
  • METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE
    Publication number: 20180065937
    Abstract: The present application relates to methods of preparing Compound A: or a salt thereof, and a polymorph of Compound A dihydrochloride salt:
    Type: Application
    Filed: November 1, 2017
    Publication date: March 8, 2018
    Inventors: Craig BATES, Jianmin MAO, David P. REED
  • AMINO-PYRROLOPYRIMIDINONE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20180055846
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: August 23, 2017
    Publication date: March 1, 2018
    Inventors: Craig BATES, Sudharshan Eathiraj, Hiroaki Inagaki, Jean-Marc Lapierre, Takayuki Momose, Kiyoshi Nakayama, Takashi Odagiri, Masahiro Ota, Yusuke Ota, Yoshihiro Shibata, Manish Tandon, Tomoyuki Tsunemi
  • Process of preparing 3-(3-(4-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-YL)pyridin-2-amine
    Patent number: 9834556
    Abstract: The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: December 5, 2017
    Assignee: ArQule, Inc.
    Inventors: Craig Bates, Jian-Xie Chen, Jianmin Mao, David P. Reed
  • Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine
    Patent number: 9834519
    Abstract: The present application relates to methods of preparing Compound A: or a salt thereof, and a polymorph of Compound A dihydrochloride salt:
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: December 5, 2017
    Assignee: ArQule, Inc.
    Inventors: Craig Bates, Jianmin Mao, David P. Reed
  • METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE
    Publication number: 20170174637
    Abstract: The present application relates to methods of preparing Compound A: or a salt thereof, and a polymorph of Compound A dihydrochloride salt:
    Type: Application
    Filed: December 16, 2016
    Publication date: June 22, 2017
    Inventors: Craig BATES, Jianmin MAO, David P. REED
  • SOLID FORMS OF SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
    Publication number: 20170174636
    Abstract: The present application provides solid forms of (R)-6-(2-fluorophenyl)-N-(3-(2-(2-methoxyethylamino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine dihydrochloride, and methods of preparing and using same.
    Type: Application
    Filed: December 16, 2016
    Publication date: June 22, 2017
    Inventors: Craig BATES, David P. REED
  • PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE
    Publication number: 20160376270
    Abstract: The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:
    Type: Application
    Filed: September 7, 2016
    Publication date: December 29, 2016
    Inventors: Craig Bates, Jian-Xie Chen, Jianmin Mao, David P. Reed
  • Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-yl)pyridin-2-amine
    Patent number: 9464083
    Abstract: The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: October 11, 2016
    Assignee: ArQule Inc.
    Inventors: Craig Bates, Jian-Xie Chen, Jianmin Mao, David P. Reed
  • Salts and polymorphs of a substituted imidazopyridinyl-aminopyridine compound
    Patent number: 9422283
    Abstract: The present application relates to salts of Compound A, 3-(3-(4-(1-aminocyclobutyl) phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine, solid state forms of Compound A free base or of salts of Compound A, amorphous forms of Compound A free base or of salts of Compound A, crystalline forms of Compound A free base or of salts of Compound A, polymorphs of Compound A free base or of salts of Compound A, and mesomorphs of Compound A free base or of salts of Compound A. The present application also relates to pharmaceutical compositions comprising these salts, solid state forms, amorphous forms, crystalline forms, polymorphs, or mesomorphs of Compound A free base or of salts of Compound A. The present application provides methods for preparing these salts, solid state forms, amorphous forms, crystalline forms, polymorphs, or mesomorphs of Compound A free base or of salts of Compound A.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: August 23, 2016
    Assignee: ArQule, Inc.
    Inventors: Craig Bates, Jianmin Mao, David Reed