Abstract: The present disclosure provides a method of treating hemophilia A in a human subject in need thereof comprising administering to the subject a chimeric protein comprising (i) a factor VIII (FVIII) protein and (ii) a von Willebrand factor (VWF) fragment comprising a D? domain of VWF and a D3 domain of VWF.

Abstract: Several novel components for Travel Bags and Travel Bag accessories are disclosed including a retractable trolley which has multiple adjustable handle heights along substantially all of the range of distance of its telescopic trolley tubes which permits the user to select and to fix the trolley pull handles at a height of their selection, a retractable hingeless plastic cover which in a closed position covers and protects an opening for a removable battery and which in open position permits the removal of the removable battery and/or access by the user to the battery face for charging and recharging purposes; a divider which can be fastened in place with adjustable side squeeze buckles or releasing and fastening clips either of which are adjustable to hold the contents in place; a battery latching and ejection system for a removable battery, a retractable power chord for rechargeable batteries or rechargeable electronic devices, and a connector cap which connects a vacuum pump with a vacuum compression bag va

Abstract: Several novel components for Travel Bags and Travel Bag accessories are disclosed including a retractable trolley which has multiple adjustable handle heights along substantially all of the range of distance of its telescopic trolley tubes which permits the user to select and to fix the trolley pull handles at a height of their selection, a retractable hingeless plastic cover which in a closed position covers and protects an opening for a removable battery and which in open position permits the removal of the removable battery and/or access by the user to the battery face for charging and recharging purposes; a divider which can be fastened in place with adjustable side squeeze buckles or releasing and fastening clips either of which are adjustable to hold the contents in place; a battery latching and ejection system for a removable battery, a retractable power chord for rechargeable batteries or rechargeable electronic devices, and a connector cap which connects a vacuum pump with a vacuum compression bag va

Abstract: Various types of travel bags are provided with at least one portable self-contained vacuum compression system having a portable vacuum pump powered by a portable, preferably removable, rechargeable battery, a compression connection system, and a vacuum compression bag secured within the interior space of the travel bag. The portable self-contained vacuum compression system allows the user to pack more clothing or compressible goods into their travel bag via the use of vacuum compression. The air inside the compression bag can be evacuated by the attached self-contained vacuum pump assembly which is secured within the travel bag in a manner to hold the self-contained vacuum system within the travel bag's internal dimensions in one embodiment. The vacuum compression system can be held in place via a removable or a fixed frame that permits operation of the vacuum compression system within the internal dimensions of the travel bag.

Abstract: Various types of travel bags are provided with at least one portable self-contained vacuum compression system having a portable vacuum pump powered by a portable, preferably removable, rechargeable battery, a compression connection system, and a vacuum compression bag secured within the interior space of the travel bag. The portable self-contained vacuum compression system allows the user to pack more clothing or compressible goods into their travel bag via the use of vacuum compression. The air inside the compression bag can be evacuated by the attached self-contained vacuum pump assembly which is secured within the travel bag in a manner to hold the self-contained vacuum system within the travel bag's internal dimensions in one embodiment. The vacuum compression system can be held in place via a removable or a fixed frame that permits operation of the vacuum compression system within the internal dimensions of the travel bag.

Abstract: Various types of travel bags are provided with at least one portable self-contained vacuum compression system having a portable vacuum pump powered by a portable, preferably removable, rechargeable battery, a compression connection system, and a vacuum compression bag secured within the interior space of the travel bag. The portable self-contained vacuum compression system allows the user to pack more clothing or compressible goods into their travel bag via the use of vacuum compression. The air inside the compression bag can be evacuated by the attached self-contained vacuum pump assembly which is secured within the travel bag in a manner to hold the self-contained vacuum system within the travel bag's internal dimensions in one embodiment. The vacuum compression system can be held in place via a removable or a fixed frame that permits operation of the vacuum compression system within the internal dimensions of the travel bag.

Abstract: A computing system wirelessly receives data from an ear-wearable device and determines, based on the data received from the ear-wearable device, a current position of the ear-wearable device. Additionally, the computing system determines, based on the current position of the ear-wearable device and data regarding a golf course, golf advice data that provides a recommendation regarding play of the golf course. Furthermore, the computing system wirelessly sends audio data to the ear-wearable device. The audio data represents soundwaves of a vocalization of the golf advice data.

Abstract: A computing system wirelessly receives data from an ear-wearable device and determines, based on the data received from the ear-wearable device, a current position of the ear-wearable device. Additionally, the computing system determines, based on the current position of the ear-wearable device and data regarding a golf course, golf advice data that provides a recommendation regarding play of the golf course. Furthermore, the computing system wirelessly sends audio data to the ear-wearable device. The audio data represents soundwaves of a vocalization of the golf advice data.

Abstract: The present subject matter include methods and apparatus for creating three dimensional digitized models of at least one ear impression, the apparatus comprising a frame, a linear axis mounted to the frame, the linear axis having an axis of motion, a first spindle axis mounted to the frame, the spindle axis having an axis of rotation, wherein the axis of rotation of the first spindle axis is parallel to the axis of motion of the linear axis, a first scanner mounted to the linear axis, the scanner includes a laser for projecting a narrowly localized spot of laser light at a target mounted on the first spindle axis and a sensor array for receiving at least a portion of the laser light reflected from the target and a controller configured to communicate with the first scanner.

Abstract: The present subject matter include methods and apparatus for creating three dimensional digitized models of at least one ear impression, the apparatus comprising a frame, a linear axis mounted to the frame, the linear axis having an axis of motion, a first spindle axis mounted to the frame, the spindle axis having an axis of rotation, wherein the axis of rotation of the first spindle axis is parallel to the axis of motion of the linear axis, a first scanner mounted to the linear axis, the scanner includes a laser for projecting a narrowly localized spot of laser light at a target mounted on the first spindle axis and a sensor array for receiving at least a portion of the laser light reflected from the target and a controller configured to communicate with the first scanner.

Abstract: Methods are provided for screening for the necessity for further diagnosis of one or more diseases or conditions in a subject, which methods are based on the discovery that abnormal levels of selected analytes in a sample fluid from a subject can be correlated with specific diseases or conditions. Further provided are criteria, and methods for the determine thereof, for selected analytes with respect to selected diseases or conditions. Thus, a variety of diseases or conditions can be screened in a rapid, cost-effective composite assay. The methods are useful for screening of newborn humans for a variety of diseases and conditions, whereby additional diagnostic procedures need only be conducted for those diseases or conditions indicated by the methods of the invention.

Abstract: The present subject matter include methods and apparatus for creating three dimensional digitized models of at least one ear impression, the apparatus comprising a frame, a linear axis mounted to the frame, the linear axis having an axis of motion, a first spindle axis mounted to the frame, the spindle axis having an axis of rotation, wherein the axis of rotation of the first spindle axis is parallel to the axis of motion of the linear axis, a first scanner mounted to the linear axis, the scanner includes a laser for projecting a narrowly localized spot of laser light at a target mounted on the first spindle axis and a sensor array for receiving at least a portion of the laser light reflected from the target and a controller configured to communicate with the first scanner.

Abstract: The present subject matter include methods and apparatus for creating three dimensional digitized models of at least one ear impression, the apparatus comprising a frame, a linear axis mounted to the frame, the linear axis having an axis of motion, a first spindle axis mounted to the frame, the spindle axis having an axis of rotation, wherein the axis of rotation of the first spindle axis is parallel to the axis of motion of the linear axis, a first scanner mounted to the linear axis, the scanner includes a laser for projecting a narrowly localized spot of laser light at a target mounted on the first spindle axis and a sensor array for receiving at least a portion of the laser light reflected from the target and a controller configured to communicate with the first scanner.

Abstract: A biochemical image is derived from specimens, preferably obtained from a statistically relevant sample of a subject population sharing a common characteristic. The biochemical images for one or more conditions present in the subject population and/or one or more test subjects are determined and made available for computer implemented diagnostic evaluations and medical research. In addition to using the information for general research purposes, information from the images may be used to classify diseases and disease states.