Patents by Inventor Craig Bentzen

Craig Bentzen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,1-and 1,2-Bisphosphonates as apoliprotein e modulators
    Publication number: 20060205692
    Abstract: The present invention relates to methods of use 1,1- and 1,2-bisphosphonate compounds to modulate apolipoprotein E levels and use of such compounds in therapy, including cardiovascular and neurological disease states.
    Type: Application
    Filed: May 9, 2003
    Publication date: September 14, 2006
    Inventors: Imber Montes, Hieu Pham, Lan Nguyen, Vinh Diep, Emanuele Burattini, Carlo Severi, Eric Neisor, Anne Perez, Jean-Luc Thuillard, Yves Guyon-Gellin, Craig Bentzen
  • Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators
    Publication number: 20060128667
    Abstract: The present invention relates to the novel hydroxyphosphonates and phosphonophosphates and the methods of their use to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states.
    Type: Application
    Filed: May 9, 2003
    Publication date: June 15, 2006
    Inventors: Imber Montes, Hieu Phan, Lan Nguyen, Emanuele Burattini, Eric Neisor, Anne Perez, Jean Luc Thuillard, Yves Guvon-Gellin, Craig Bentzen
  • Methods for inducing apolipoprotein e secretion
    Publication number: 20060035873
    Abstract: The invention provides a method for increasing apolipoprotein E (ApoE) in plasma and in tissues of a mammal by using a combination of an ApoE increasing amount of an activator of the orphan nuclear receptor FXR and an ApoE increasing amount of an activator of the orphan nuclear receptor LXR?. Also provided is the use of a combination of an ApoE increasing amount of a FXR activator and of an ApoE increasing amount of a LXR? activator, for the manufacture of a medicament for increasing ApoE in plasma and in tissues of a mammal.
    Type: Application
    Filed: August 2, 2001
    Publication date: February 16, 2006
    Inventors: Eric Niesor, Ane Perez, Jean-Luc Thuillard, Craig Bentzen, Lan Nguyen
  • Phosphonate-phosphate and diphosphonate apolipoprotein e modulators
    Publication number: 20060009423
    Abstract: The present invention relates to methods of use of phosphonate-phosphates and diphosphonates to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states.
    Type: Application
    Filed: February 14, 2003
    Publication date: January 12, 2006
    Inventors: Eric Joseph Niesor, Craig Bentzen, Lan Nguyen
  • Alpha-substituted beta-aminoethyl phosphonate derivatives
    Publication number: 20050187193
    Abstract: The present invention relates to novel ?-substituted-?-aminoethylphosphonate and ?-substituted-?-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Application
    Filed: December 1, 2004
    Publication date: August 25, 2005
    Inventors: Hieu Phan, Lan Nguyen, Vinh Van Diep, Raymond Azoulay, Harald Eschenhof, Eric Niesor, Craig Bentzen, Robert Ife
  • Alpha-substituted heteroarylalkyl phosphonate derivatives
    Publication number: 20050124581
    Abstract: The present invention relates to novel ?-substituted heteroarylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Application
    Filed: February 3, 2003
    Publication date: June 9, 2005
    Inventors: Hieu Phan, Lan Nguyen, Raymond Azoulay, Vinh Diep, Eric Niesor, Craig Bentzen, Robert Ife
  • Alpha-substituted arylalkyl phosphonate derivatives
    Publication number: 20050124586
    Abstract: The present invention relates to novel ?-substituted arylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Application
    Filed: February 3, 2003
    Publication date: June 9, 2005
    Inventors: Hieu Phan, Lan Nguyen, Raymond Azoulay, Vinh Diep, Harald Eschenhof, Eric Niesor, Craig Bentzen, Robert Ife
  • Aminodiphosphonate apolipoprotein e modulators
    Publication number: 20050075317
    Abstract: The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states.
    Type: Application
    Filed: February 14, 2003
    Publication date: April 7, 2005
    Inventors: Hieu Phan, Lan Nguyen, Raymond Azoulay, Vinh Diep, Eric Niesor, Craig Bentzen, Yves Gellin, Anne Perez, Jean-Luc Thulliard
  • Method for lowering plasma lipid levels or blood pressure
    Patent number: 5128331
    Abstract: The invention relates to new gem-diphosphonates derivatives substituted by phenol groups of formula (I): ##STR1## as well as the process for their preparation and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: July 7, 1992
    Assignee: Symphar S.A.
    Inventors: Lan Nguyen, Eric Niesor, Hieu Phan, Pierre Maechler, Craig Bentzen
  • Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them
    Patent number: 5043330
    Abstract: The invention relates to new gem-diphosphonates derivatives substituted by phenol groups of formula (I): ##STR1## as well as the process for their preparation and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 14, 1989
    Date of Patent: August 27, 1991
    Assignee: Symphar S.A.
    Inventors: Lan Nguyen, Eric Niesor, Hieu Phan, Pierre Maechler, Craig Bentzen