Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: Disclosed herein are methods for identifying physicochemical properties associated with protein corona formation at the level of proteins and NP-functionalization. Further disclosed herein are compositions comprising combinations of particles configured for low abundance protein collection and deep proteomic analysis.

Abstract: A method of sealing a well having a casing wall comprises transporting a camera into the casing wall making a visual recording by visually recording perforations, microfractures or other breach type damages of the wall and vertical location thereof on the wall. Selecting a vertical location for sealing the well, the vertical location being determined from the visual recording. Transporting an expandable sealing device being made of an expandable metal and a hydraulic cylinder attached to the sealing device by a shear pin into the well. Expanding the sealing device to engage the casing wall such that a gas seal is made between the sealing device and the casing wall, the sealing device being expanded through engagement by the hydraulic cylinder.

Abstract: Provided herein are media, systems, and methods that identify the address of a rental property from public sources (e.g., rental listings, maps, and county property records). A data mining task process may be performed, by each of a plurality of first data ingestion interfaces to a unique external property data source, to determine at least one property record depiction, each property record depiction associated with a property record. A first machine learning algorithm may be applied to the at least one rental property depiction and the at least one property record depiction from each data source to identify one or more common property records, wherein each common property record comprises a property record that refers to the rental property. A data mining task process may be performed, by a second data ingestion interface to the one or more common property records to determine the street address of the rental property.

Abstract: The embodiments disclosed herein relate to an apparatus for monitoring a valve having a control element, wherein the control element is actuated by an actuator, having: an adaptor between the control element and the actuator, wherein the adaptor couples a valve stem of the control element to the actuator; and an electronics module contained within the adaptor, wherein the electronics module further comprises one or more sensors.

Abstract: Described are medias, systems, and computer-implemented methods to detect improper residency status by performing a data mining task to data source to detect one or more improper residency indicia, applying a machine learning algorithm to identify an initial candidate, calculating a probability that the initial candidate has an improper residency status, and validating the detection. Further described are medias, systems, and computer-implemented methods to detect improper occupancy tax status. Further described are medias, systems, and computer-implemented methods to detect an improper homeowner exemption.

Abstract: An apparatus and method of use for dampening shock and vibration imparted on a unified (e.g., single) and/or dual telemetry measurement-while-drilling (MWD) assembly by a drilling system during the drilling of a wellbore in a subterranean formation is provided. The apparatus may be configured to be threadably engaged and housed within the drilling system, wherein the apparatus reciprocates axially with the MWD assembly, dampening axial and torsional shock and vibration imparted on the assembly, while maintain mud-pulse and electromagnetic signals transmitted by the assembly.

Abstract: The embodiments disclosed herein relate to an apparatus for monitoring a valve having a control element, wherein the control element is actuated by an actuator, having: an adaptor between the control element and the actuator, wherein the adaptor couples a valve stem of the control element to the actuator; and an electronics module contained within the adaptor, wherein the electronics module further comprises one or more sensors.

Abstract: A method and an apparatus for sealing perforations or cracks found in an oil well casing. The apparatus includes a hydraulic cylinder with an oil supply section at one end and a rod at another end, a cylindrical liner at least a portion of which is a malleable metal and a receiver, the liner with an outer diameter suitable for entry in to the well casing; and a frusto-conical wedge being disposed at a lower end of the liner and fixedly connected to the rod, the frusto-conical wedge having a section with a diameter larger than an inner diameter of the liner.

Abstract: A magnetically coupled piston pump includes a piston, a pump body, and a set of drive magnets. The piston includes a set of piston magnets. Each piston magnet has poles arranged along a longitudinal axis of the piston, and each piston magnet is arranged in the piston so that the orientation of the poles of each piston magnet is the opposite of the orientation of each adjacent piston magnet. The piston is disposed in and permitted to move within the pump body. The set of drive magnets is arranged outside the pump body. Each drive magnet corresponds to a piston magnet, has poles arranged along the longitudinal axis, and is arranged so that the orientation of the poles is opposite the orientation of the poles of the corresponding piston magnet. A drive unit is coupled to the drive magnets for moving the drive magnets along the longitudinal axis.

Abstract: The embodiments disclosed herein relate to an apparatus for monitoring a valve having a control element, wherein the control element is actuated by an actuator, having: a valve stem, wherein the valve stem is connected to the control element; a cavity defined within the valve stem; an electronics module embedded within the cavity of the valve stem, wherein the electronics module further has one or more sensors within the valve stem; and wherein the electronic module further has a microprocessor within the valve stem; and a conductor connecting the electronics module to the actuator.

Abstract: A method of sealing a well having a casing wall comprises transporting a camera into the casing wall making a visual recording by visually recording perforations, microfractures or other breach type damages of the wall and vertical location thereof on the wall. Selecting a vertical location for sealing the well, the vertical location being determined from the visual recording. Transporting an expandable sealing device being made of an expandable metal and a hydraulic cylinder attached to the sealing device by a shear pin into the well. Expanding the sealing device to engage the casing wall such that a gas seal is made between the sealing device and the casing wall, the sealing device being expanded through engagement by the hydraulic cylinder.

Abstract: The embodiments disclosed herein relate to an apparatus for monitoring a valve having a control element, wherein the control element is actuated by an actuator, including a valve stem having a bore therethrough, wherein the bore is defined by a wall of the valve stem, and further wherein the valve stem is connected at a first end to the actuator and at a second end to the control element; and an electronics module within the bore of the valve stem, wherein the electronics module further includes one or more sensors within the valve stem.

Abstract: The disclosure relates to a valve having: an actuator; a valve position indicator coupled to the actuator, wherein the valve position indicator includes: an indicator cover mounted over an indicator mounting surface, wherein the indicator mounting surface has a rim; a plurality of LED lights arranged on the indicator mounting surface, wherein the LED lights are bordering the rim of the indicator cover; and a sensor in communicative connection with the actuator and the plurality of LED lights, wherein the sensor is configured to communicate the position of the valve to the plurality of LED lights.

Abstract: Provided herein are media, systems, and methods that identify the address of a rental property from public sources (e.g., rental listings, maps, and county property records). A data mining task process may be performed, by each of a plurality of first data ingestion interfaces to a unique external property data source, to determine at least one property record depiction, each property record depiction associated with a property record. A first machine learning algorithm may be applied to the at least one rental property depiction and the at least one property record depiction from each data source to identify one or more common property records, wherein each common property record comprises a property record that refers to the rental property. A data mining task process may be performed, by a second data ingestion interface to the one or more common property records to determine the street address of the rental property.

Abstract: Described are medias, systems, and computer-implemented methods to detect improper residency status by performing a data mining task to data source to detect one or more improper residency indicia, applying a machine learning algorithm to identify an initial candidate, calculating a probability that the initial candidate has an improper residency status, and validating the detection. Further described are medias, systems, and computer-implemented methods to detect improper occupancy tax status. Further described are medias, systems, and computer-implemented methods to detect an improper homeowner exemption.

Abstract: A magnetically coupled piston pump includes a piston, a pump body, and a set of drive magnets. The piston includes a set of piston magnets. Each piston magnet has poles arranged along a longitudinal axis of the piston, and each piston magnet is arranged in the piston so that the orientation of the poles of each piston magnet is the opposite of the orientation of each adjacent piston magnet. The piston is disposed in and permitted to move within the pump body. The set of drive magnets is arranged outside the pump body. Each drive magnet corresponds to a piston magnet, has poles arranged along the longitudinal axis, and is arranged so that the orientation of the poles is opposite the orientation of the poles of the corresponding piston magnet. A drive unit is coupled to the drive magnets for moving the drive magnets along the longitudinal axis.

Abstract: The embodiments disclosed herein relate to an apparatus for monitoring a valve having a control element, wherein the control element is actuated by an actuator, having: an adaptor between the control element and the actuator, wherein the adaptor couples a valve stem of the control element to the actuator; and an electronics module contained within the adaptor, wherein the electronics module further comprises one or more sensors.

Abstract: The embodiments disclosed herein relate to an apparatus for monitoring a valve having a control element, wherein the control element is actuated by an actuator, including a valve stem having a bore therethrough, wherein the bore is defined by a wall of the valve stem, and further wherein the valve stem is connected at a first end to the actuator and at a second end to the control element; and an electronics module within the bore of the valve stem, wherein the electronics module further includes one or more sensors within the valve stem.

Abstract: The disclosure relates to a valve having: an actuator; a valve position indicator coupled to the actuator, wherein the valve position indicator includes: an indicator cover mounted over an indicator mounting surface, wherein the indicator mounting surface has a rim; a plurality of LED lights arranged on the indicator mounting surface, wherein the LED lights are bordering the rim of the indicator cover; and a sensor in communicative connection with the actuator and the plurality of LED lights, wherein the sensor is configured to communicate the position of the valve to the plurality of LED lights