Abstract: Systems and methods directed to aldehyde detection are disclosed. An aldehyde detection system may capture aldehydes from a patient breath sample. Aldehydes of the breath sample may be used to form a mobile chromatography phase within an analysis device. The analysis device may include various modules configured to perform a high pressure liquid chromatography process that separates aldehydes according to size. A detection assembly may detect a relative value of the separated aldehydes. The analysis device may be configured to determine an aldehyde score or metric based on the detected aldehydes, which may assist in the diagnosis of certain medical conditions.

Abstract: Methods, systems and reagents are provided for detecting and quantifying carbonyl containing moieties in a variety of sample types.

Abstract: Systems and methods directed to aldehyde detection are disclosed. An aldehyde detection system may capture aldehydes from a patient breath sample. Aldehydes of the breath sample may be used to form a mobile chromatography phase within an analysis device. The analysis device may include various modules configured to perform a high pressure liquid chromatography process that separates aldehydes according to size. A detection assembly may detect a relative value of the separated aldehydes. The analysis device may be configured to determine an aldehyde score or metric based on the detected aldehydes, which may assist in the diagnosis of certain medical conditions.

Abstract: A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

Abstract: Methods, systems and reagents are provided for detecting and quantifying carbonyl containing moieties in a variety of sample types. The amount of time elapsed from capturing of the carbonyl containing moieties from a sample to the detection of the carbonyl containing moieties is less than about 2 hours. Compounds are provided to facilitate labeling and detection of the carbonyl containing moieties.

Abstract: A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.