Abstract: Systems, devices, and methods for treating a patient are disclosed. The systems can include a cryotherapy apparatus for selectively treating targeted tissue. The cryotherapy apparatus includes one or more stress relief couplings located along a conduit to help keep an applicator positioned at a treatment site without significant rotational torque being imparted to the applicator by the conduit so that the applicator does not tend to move relative to patient skin during a tissue treatment. The stress relief couplings can include swivel connectors and clamps that cooperate to minimize or limit a rotational force exerted on the applicator by the conduit after the applicator is applied to the patient's skin.

Abstract: Disclosed are two-handed IUD insertion devices for positioning an intrauterine device (IUD) in the uterus which includes a plunger, a sheath, a grip and a handle where the axial movement of the plunger is controlled via features along the length of the plunger in communication with a grip feature.

Abstract: This invention relates generally to the use of ITK (IL-2 inducible T-cell kinase) inhibitors for the treatment of patients who have melanoma or other solid tumors. Applicants demonstrate that ITK lentiviral small hairpin RNA knockdowns and a small molecule inhibitor can each decrease the proliferation and migration of melanoma cell lines and a small molecule inhibitor can be used to inhibit the growth of melanomas in vivo.

Abstract: Systems, devices, and methods for treating a patient are disclosed. The systems can include a cryotherapy apparatus for selectively treating targeted tissue. The cryotherapy apparatus includes one or more stress relief couplings located along a conduit to help keep an applicator positioned at a treatment site without significant rotational torque being imparted to the applicator by the conduit so that the applicator does not tend to move relative to patient skin during a tissue treatment. The stress relief couplings can include swivel connectors and clamps that cooperate to minimize or limit a rotational force exerted on the applicator by the conduit after the applicator is applied to the patient's skin.

Abstract: This invention relates generally to the use of ITK (IL-2 inducible T-cell kinase) inhibitors for the treatment of patients who have melanoma or other solid tumors. Applicants demonstrate that ITK lentiviral small hairpin RNA knockdowns and a small molecule inhibitor can each decrease the proliferation and migration of melanoma cell lines and a small molecule inhibitor can be used to inhibit the growth of melanomas in vivo.

Abstract: A linen fastener, including: a hub; and a magnet at least partially disposed within the hub. The hub is arranged to be placed against a first exterior surface of layered linens such that magnetic force from the magnet engages an element located on a second exterior surface of the layered linens, opposite the first exterior surface, to clamp the layered linens between the hub and the element. A method of fastening linen using a fastener including a hub and a magnet at least partially disposed within the hub, including: placing the hub against a first exterior surface of layered linens; engaging, with magnetic force from the magnet, an element located on a second exterior surface of the layered linens, opposite the first exterior surface; and clamping the layered linens between the hub and the element.

Abstract: A plastic pallet having a deck and underside with numerous runners having arched members in the base of orifices in the runners. The pallet preferably has a corresponding concave entry in the underside of the deck forming the top of each orifice. The concave entries are substantially equidistant from the arched top portion of the base member. The pallet may include reinforcement bars that are C-shaped with lips on each end, wherein plastic forms around the edges of the lips. The pallet may have a center runner along a center of the underside of the pallet with two side runners each forming a passageway with the center runner so that all four sides of the pallet are accessible through orifices or passageways. The leading edge of the runner may be slightly angled upwardly to improve conveyability. The pallet may have ribs extending from the deck and underdeck channels, which may be reinforced, oriented at approximately right angles from the ribs.

Abstract: The identification and evaluation of mRNA and protein targets associated with mRNP complexes and implicated in the expression of proteins involved in common physiological pathways is described. Effective targets are useful for treating a disease, condition or disorder associated with the physiological pathway.

Abstract: Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor tissue. Ligands include antibodies that specifically bind RNA-binding or RNA-associated proteins present in the mRNP complex. The mRNP complex is separated by binding the ligand with a binding molecule specific for the ligand, where the binding molecule is attached to a solid support. The mRNP complex is collected by removing the mRNP complex from the solid support. After collecting the mRNP complex, the mRNA bound within the complex may be characterized and identified. Subsets of the total mRNA population of a cell may accordingly be characterized, and a gene expression profile of the cell obtained.

Abstract: A one-piece, hollow, continuous wall pallet having a deck and underside structural features that function in conjunction with the deck for support and reinforcement when a load is placed on the pallet or when a side of the pallet is impacted. The structural features may include an arched bottom recess, side impact depressions, and kiss-off structures, in one of the legs or portion of the underside. The pallet deck may have a dual entry rib configuration. The pallet is preferably made using rotational molding.

Abstract: A one-piece, hollow, continuous wall pallet having a deck and underside structural features that function in conjunction with the deck for support and reinforcement when a load is placed on the pallet or when a side of the pallet is impacted. The structural features may include an arched bottom recess, side impact depressions, and kiss-off structures, in one of the legs or portion of the underside. The pallet deck may have a dual entry rib configuration. The pallet is preferably made using rotational molding.

Abstract: A one-piece, hollow, continuous wall pallet having a deck and underside structural features that function in conjunction with the deck for support and reinforcement when a load is placed on the pallet or when a side of the pallet is impacted. The structural features include an arched bottom recess, side impact depressions, and kiss-off structures, in one of the legs or portion of the underside. The pallet is preferably made using rotational molding.