Patents by Inventor Craig D. Blanchette

Craig D. Blanchette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240059755
    Abstract: The present invention generally relates to nanolipoprotein particle conjugates comprising at least one polypeptide and nanolipoprotein particle conjugates comprising at least one short peptide between 20-60 amino acids in length. Also provided are related compositions and systems, and methods of preparing and using same. In particular, nanolipoprotein particle (NLP) conjugates with antigen-binding fragments (Fabs) are provided, where the NLP comprises a bilayer of membrane-forming lipids encircled by scaffold proteins, and the Fabs are conjugated to one or both bilayer surfaces. In some embodiments, the (NLP) conjugates further comprise a short peptide 20-60 amino acids in length.
    Type: Application
    Filed: December 9, 2022
    Publication date: February 22, 2024
    Applicant: Genentech, Inc
    Inventors: Whitney BINDER, Craig D. BLANCHETTE, Martine A. DARWISH, Rami HANNOUSH, Xinxin GAO
  • Publication number: 20220211866
    Abstract: A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a Chlamydia major outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems.
    Type: Application
    Filed: December 23, 2021
    Publication date: July 7, 2022
    Inventors: Matthew A. COLEMAN, Nicholas O. FISCHER, Amy RASLEY, Craig D. BLANCHETTE, Todd PETERSON
  • Patent number: 11207422
    Abstract: A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a Chlamydia major outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: December 28, 2021
    Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Matthew A. Coleman, Nicholas O. Fischer, Amy Rasley, Craig D. Blanchette, Todd Peterson
  • Publication number: 20200046848
    Abstract: A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a Chlamydia major outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems.
    Type: Application
    Filed: May 1, 2018
    Publication date: February 13, 2020
    Inventors: Matthew A. COLEMAN, Nicholas O. FISCHER, Amy RASLEY, Craig D. BLANCHETTE, Todd PETERSON
  • Publication number: 20190307692
    Abstract: Nanolipoprotein particles comprising at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems are described, in which the membrane lipid component comprises at least one or more membrane forming lipids and one or more lysoplipids.
    Type: Application
    Filed: March 3, 2017
    Publication date: October 10, 2019
    Inventors: Craig D. BLANCHETTE, Nicholas FISCHER, Sean Fitzpatrick GILMORE, Paul HENDERSON
  • Publication number: 20190142752
    Abstract: Nanolipoprotein particles having at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems are described. The membrane lipid component includes at least one or more membrane forming lipids, one or more polymerized lipids and/or one or more polymerizable lipids.
    Type: Application
    Filed: August 25, 2016
    Publication date: May 16, 2019
    Inventors: Craig D. BLANCHETTE, Nicholas FISCHER, Sean Fitzpatrick GILMORE, Amy RASLEY, Paul HENDERSON
  • Patent number: 10202567
    Abstract: According to one general embodiment, a membrane, includes a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network. According to another embodiment, a bioreactor includes a lattice of three dimensional structures, each structure including a membrane having: a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: February 12, 2019
    Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Joshuah K. Stolaroff, Roger Aines, Sarah Baker, Craig D. Blanchette, Amitesh Maiti, John Vericella, James S. Oakdale
  • Publication number: 20180318218
    Abstract: Nanolipoprotein particles comprising at least a scaffold protein component and a membrane lipid component and related complexes, compositions, methods and systems are described, in which the membrane lipid component comprises at least one or more membrane forming lipids and one or more cationic lipids.
    Type: Application
    Filed: May 2, 2018
    Publication date: November 8, 2018
    Inventors: Kurt I. Kamrud, Nathaniel S. Wang, Martina Felderman, Bolyn Hubby, Heather D. Gouvis, Nicholas O. Fischer, Matthew A. Coleman, Angela Clare Evans, Wei He, Amy Rasley, Craig D. Blanchette
  • Publication number: 20170211026
    Abstract: According to one general embodiment, a membrane, includes a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network. According to another embodiment, a bioreactor includes a lattice of three dimensional structures, each structure including a membrane having: a polymeric network configured to separate a first fluid and a second fluid, where the first and second fluids are different; and a plurality of enzymatic reactive components embedded within the polymeric network.
    Type: Application
    Filed: January 21, 2016
    Publication date: July 27, 2017
    Inventors: Joshuah K. Stolaroff, Roger Aines, Sarah Baker, Craig D. Blanchette, Amitesh Maiti, John Vericella, James S. Oakdale
  • Patent number: 8883729
    Abstract: Functionalized nanolipoprotein particle presenting an anchor substrate compound for binding with a corresponding anchor compound presented on a target molecule, and related compositions methods and systems.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: November 11, 2014
    Assignees: Lawrence Livermore National Security, LLC, The Board of Regents of the University of Texas System
    Inventors: Paul D. Hoeprich, Nicholas O. Fischer, Peter W. Mason, Craig D. Blanchette
  • Publication number: 20090311276
    Abstract: Functionalized nanolipoprotein particle presenting an anchor substrate compound for binding with a corresponding anchor compound presented on a target molecule, and related compositions methods and systems.
    Type: Application
    Filed: May 20, 2009
    Publication date: December 17, 2009
    Inventors: Paul D. Hoeprich, Nicholas O. Fischer, Peter W. Mason, Craig D. Blanchette