Abstract: A massively parallel electrophoresis system comprised of capillaries, with means for parallel imaging of the capillary ends. The capillaries are aligned with parallel longitudinal axes and a set of ends that are substantially coplanar. The electrophoresis system has a source of excitation radiation for illuminating the ends while an imaging optical arrangement places substantially coplanar loci, one per capillary, within a focal region of the imaging optical arrangement. A detector module receives electromagnetic radiation that is emitted by fluorophores within the capillaries upon excitation by the excitation radiation and transmitted to the detector module by way of the imaging optical arrangement.

Abstract: A surgical instrument is adapted for applying a plurality of surgical fasteners to body tissue. The surgical instrument includes a frame having a proximal end and a distal end, with a handle positioned at the proximal end and an end effector positioned at the distal end. The end effector is shaped and dimensioned for supporting a cartridge housing and an anvil, the cartridge housing and anvil being relatively movable by actuation of a closure mechanism. The surgical instrument further includes a firing mechanism associated with the end effector and the cartridge housing for selective actuation of the surgical fasteners features. The surgical instrument also includes a retaining pin for enclosing tissue between the anvil and the cartridge housing. The retaining pin is moved by actuation of the closure mechanism from an open first position to a closed second position.