Patents by Inventor Craig Geoffrey Freeman
Craig Geoffrey Freeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9226939Abstract: The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.Type: GrantFiled: November 29, 2011Date of Patent: January 5, 2016Assignee: THE AUSTRALIAN NATIONAL UNIVERSITYInventors: Ross Wentworth Stephens, Christopher Richard Parish, Craig Geoffrey Freeman, Timothy John Senden
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Publication number: 20130338097Abstract: The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.Type: ApplicationFiled: November 29, 2011Publication date: December 19, 2013Applicant: THE AUSTRALIAN NATIONAL UNIVERSITYInventors: Ross Wentworth Stephens, Christopher Richard Parish, Craig Geoffrey Freeman, Timothy John Senden
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Publication number: 20130143840Abstract: The present invention relates to a method for inhibiting oxidative damage of islet beta cells in vivo in a subject by administering to the subject a therapeutically effective amount of heparan sulfate capable of protecting islet beta cells from reactive oxygen species or in vitro by exposing isolated islet beta cells, prior to transplantation, to a concentration of heparan sulfate that protects them from reactive oxygen species.Type: ApplicationFiled: March 11, 2011Publication date: June 6, 2013Inventors: Christopher Richard Parish, Charmaine Simeonovic, Craig Geoffrey Freeman
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Patent number: 7173019Abstract: The invention relates to compounds of the following formula (I). In these compounds, R1, R2, R3 and R4 are each independently a substituted or unsubstituted cyclitol with a ring comprising six carbon atoms, or hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, alkyloxycarbonyl, or alkylaminocarbonyl. At least two of R1, R2, R3 and R4 comprise the substituted or unsubstituted cyclitol. The linker can be any one of the following: —(CH2)w—, —(CH2)x—C6H4—(CH2)x—, —(CH2)y—NR5—(CH2)y—, and —(CH2)z—HCR6—(CH2)z—; wherein: w, x, y and z are independently an integer having a value of 0–10; R5 is a substituted or unsubstituted cyclitol with a ring comprising six carbon atoms; and, R6 is —OH, —OSO3Na, —OSO3Na substituted with alkyl, cycloalkyl or aryl, or substituted or unsubstituted alkyl, cycloalkyl or aryl. The compounds can also include substituted or unsubstituted cyclitol carbamides with the linker bond at the carbamide nitrogen.Type: GrantFiled: July 4, 2002Date of Patent: February 6, 2007Assignee: The Australian National UniversityInventors: Martin Gerhardt Banwell, Ligong Liu, Christopher Richard Parish, Craig Geoffrey Freeman
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Publication number: 20040019021Abstract: The invention relates to compounds of the following formula (I). In these compounds, R1, R2, R3 and R4 are each independently a substituted or unsubstituted cyclitol with a ring comprising six carbon atoms, or hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, alkyloxycarbonyl, or alkylaminocarbonyl. At least two of R1, R2, R3 and R4 comprise the substituted or unsubstituted cyclitol. The linker can be any one of the following: —(CH2)w—, —(CH2)x—C6H4—(CH2)x—, —(CH2)y—NR5—(CH2)y—, and —(CH2)z—HCR6—(CH2)z—; wherein: w, x, y and z are independently an integer having a value of 0-10; R5 is a substituted or unsubstituted cyclitol with a ring comprising six carbon atoms; and, R6 is —OH, —OSO3Na, —OSO3Na substituted with alkyl, cycloalkyl or aryl, or substituted or unsubstituted alkyl, cycloalkyl or aryl.Type: ApplicationFiled: April 8, 2003Publication date: January 29, 2004Inventors: Martin Gerhardt Banwell, Ligong Liu, Christopher Richard Parish, Craig Geoffrey Freeman
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Patent number: 6491913Abstract: The present invention relates generally to mammalian sulphamidase and to genetic sequences encoding same and to the use of these in the investigation, diagnosis and treatment of subjects suspected of or suffering from sulphamidase deficiency.Type: GrantFiled: December 4, 2000Date of Patent: December 10, 2002Assignee: Women's and Children's HospitalInventors: John Joseph Hopwood, Hamish Steele Scott, Craig Geoffrey Freeman, Charles Phillip Morris, Lianne Cheryl Blanch, Xiao Hui Guo
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Patent number: 6458579Abstract: The present invention relates generally to mammalian sulphamidase and to genetic sequences encoding same and to the use of these in the investigation, diagnosis and treatment of subjects suspected of or suffering from sulphamidase deficiency.Type: GrantFiled: December 4, 2000Date of Patent: October 1, 2002Assignee: Women's and Children's HospitalInventors: John Joseph Hopwood, Hamish Steele Scott, Craig Geoffrey Freeman, Charles Phillip Morris, Lianne Cheryl Blanch, Xiao Hui Guo
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Publication number: 20020106358Abstract: The present invention relates generally to mammalian sulphamidase and to genetic sequences encoding same and to the use of these in the investigation, diagnosis ad treatment of subjects suspected of or suffering from sulphamidase deficiency.Type: ApplicationFiled: December 4, 2000Publication date: August 8, 2002Inventors: John Joseph Hopwood, Hamish Steele Scott, Craig Geoffrey Freeman, Charles Phillip Morris, Lianne Cheryl Blanch, Xiao Hui Guo
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Patent number: 6352852Abstract: A method for the purification of human platelet heparanase using chromatographic techniques is described. The method comprises detergent-aided solubilization of a heparanase-containing fraction followed by purification of the heparanase therefrom by concanavalin A, Zn2+-chelating Sepharose, a Blue A or Reactive Red matrix, octyl agarose and gel filtration chromatography. Heparanase so purified has a molecular mass (Mr) of about 50 kDa and degrades both heparin and heparan sulfates.Type: GrantFiled: January 24, 2000Date of Patent: March 5, 2002Assignee: The Australian National UniversityInventors: Craig Geoffrey Freeman, Christopher Richard Parish
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Publication number: 20010014323Abstract: The present invention relates generally to mammalian sulphamidase and to genetic sequences encoding same and to the use of these in the investigation, diagnosis and treatment of subjects suspected of or suffering from sulphamidase deficiency.Type: ApplicationFiled: December 4, 2000Publication date: August 16, 2001Inventors: John Joseph Hopwood, Hamish Steele Scott, Craig Geoffrey Freeman, Charles Phillip Morris, Lianne Cheryl Blanch, Xiao Hui Guo
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Patent number: 6242238Abstract: The present invention relates to isolated or recombinant mammalian endoglucuronidase enzymes, polypeptides and peptides, in particular human, murine and rat heparanases, genetic sequences encoding same and uses therefor, for example in the determination and characterisation of chemical compounds, proteins, polypeptides, small molecules and macromolecules capable of inhibiting metastasis, angiogenesis, angioplasty-induced restenosis, atherosclerosis, inflammation, promote wound healing and otherwise modulate physiological processes involving heparanase cleavage of heparan sulphate. The invention further relates to a method of altering, modifying or otherwise modulating the level of expression of mammalian heparanase in a cell. A further aspect of the invention relates to immunoreactive molecules capable of binding to and/or inhibiting mammalian heparanase, in particular monoclonal antibodies.Type: GrantFiled: October 28, 1998Date of Patent: June 5, 2001Assignee: The Australian National UniversityInventors: Craig Geoffrey Freeman, Mark Darren Hulett, Christopher Richard Parish, Brenton James Hamdorf
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Patent number: 6207402Abstract: A method for detecting mammalian heparanase activity in a sample such as mammalian tissue, cells or bodily fluids; and a method for the purification of mammalian heparanase from a heparanase-containing material, such as human platelets.Type: GrantFiled: December 28, 1998Date of Patent: March 27, 2001Assignee: The Australian National University ActInventors: Craig Geoffrey Freeman, Christopher Richard Parish
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Patent number: 6200563Abstract: The present invention relates generally to mammalian sulphamidase and to genetic sequences encoding same and to the use of these in the investigation, diagnosis and treatment of subjects suspected of or suffering from sulphamidase deficiency.Type: GrantFiled: August 9, 1999Date of Patent: March 13, 2001Assignee: Women's and Children's HospitalInventors: John Joseph Hopwood, Hamish Steele Scott, Craig Geoffrey Freeman, Charles Phillip Morris, Lianne Cheryl Blanch, Xiao Hui Guo
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Patent number: 5972333Abstract: The present invention relates generally to mammalian sulphamidase and to genetic sequences encoding same and to the use of these in the investigation, diagnosis and treatment of subjects suspected of or suffering from sulphamidase deficiency.Type: GrantFiled: June 13, 1997Date of Patent: October 26, 1999Assignee: Women's and Children HospitalInventors: John Joseph Hopwood, Hamish Steele Scott, Craig Geoffrey Freeman, Charles Phillip Morris, Lianne Cheryl Blanch, Xiao Hui Guo
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Patent number: 5863782Abstract: The present invention relates generally to mammalian sulphamidase and to genetic sequences encoding same and to the use of these in the investigation, diagnosis and treatment of subjects suspected of or suffering from sulphamidase deficiency.Type: GrantFiled: April 19, 1995Date of Patent: January 26, 1999Assignee: Women's and Children's HospitalInventors: John Joseph Hopwood, Hamish Steele Scott, Craig Geoffrey Freeman, Charles Phillip Morris, Liane Cheryl Blanch, Xiao-Nui Guo