Patents by Inventor Craig Gough

Craig Gough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide compositions mimicking TGF-&bgr; activity
    Patent number: 6638912
    Abstract: Compositions suitable for pharmaceutical administration are provided in which one compound is a small peptide mimic of TGF-&bgr;. More preferably, pharmaceutical compositions of the present invention are formulated as combinations of two components, wherein one component includes a peptide mimic for TGF-&bgr; and the other component is structurally or biologically analogous to a small region of collagen and mimics the conformation recognized by collagen binding species. A particularly preferred combination is A-N-V-A-E-N-A (SEQ ID NO:1) and G-T-P-G-P-Q-G-I-A-G-Q-R-G-V-V (SEQ ID NO:17).
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: October 28, 2003
    Assignee: The Regents of the University of California
    Inventors: Rajendra S. Bhatnagar, Jing Jing Qian, Craig Gough
  • TGF-beta inhibitors and methods
    Publication number: 20030083265
    Abstract: A family of small peptides have been found to be inhibitory to TGF-&bgr; activity, and preferably have the primary structure of Formula 1:
    Type: Application
    Filed: November 25, 2002
    Publication date: May 1, 2003
    Inventors: Rajendra S. Bhatnagar, Craig A. Gough, Jing Jing Qian
  • TGF-B inhibitors and methods
    Patent number: 6509318
    Abstract: A family of small peptides have been found to be inhibitory to TGF-&bgr; activity, and preferably have the primary structure of Formula I: AA1-AA2-AA3-Pro-D-Glu-Ala  FORMULA I wherein AA1 is leucine, phenylalanine, &agr;-aminoisobutric acid, N-methylalanine, N-methylisoleucine, or isoleucine; AA2 is the same or a different amino acid residue as in AA1; and AA3 is alanine or N-methylalanine.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: January 21, 2003
    Assignee: The Regents of the University of California
    Inventors: Rajendra S. Bhatnagar, Craig A. Gough, Jing Jing Qian
  • PEPTIDE COMPOSITIONS MIMICKING TGF-BETA ACTIVITY
    Publication number: 20020010134
    Abstract: Compositions suitable for pharmaceutical administration are provided in which one compound is a small peptide mimic of TGF-&bgr;. More preferably, pharmaceutical compositions of the present invention are formulated as combinations of two components, wherein one component includes a peptide mimic for TGF-&bgr; and the other component is structurally or biologically analogous to a small region of collagen and mimics the conformation recognized by collagen binding species. A particularly preferred combination is A-N-V-A-E-N-A (SEQ ID NO:1) and G-G-T-P-Q-I-A-G-Q-R-G-V-V (SEQ ID NO:17).
    Type: Application
    Filed: July 10, 1998
    Publication date: January 24, 2002
    Inventors: RAJENDRA S. BHATNAGAR, JING JING QIAN, CRAIG GOUGH