Abstract: Crystalline 2-hydroxy-N,N-dimethylethanaminium 1-(2-(5-(tert-butyl)-thiophene-2-carboxamido)-3-(4-(5-(4?-ethyl-[1,1?-bi(cyclohexan)]-3-en-4-yl)pyrimidin-2-yl)phenyl)propanoyl)azetidine-3-carboxylate salt, and methods related to synthesis and therapeutic use of the same.

Abstract: Crystalline 2-hydroxy-N,N-dimethylethanaminium 1-(2-(5-(tert-butyl)-thiophene-2-carboxamido)-3-(4-(5-(4?-ethyl-[1,1?-bi(cyclohexan)]-3-en-4-yl)pyrimidin-2-yl)phenyl)propanoyl)azetidine-3-carboxylate salt, and methods related to synthesis and therapeutic use of the same.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: The present invention provides methods for preventing or treating a condition characterized by undesired thrombosis in a mammal using a crystalline polymorph form of a maleate salt of a compound of Formula I that has activity against mammalian factor Xa.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: Crystalline forms of the sulfate salt of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid (4-isopropoxyphenyl)-amide, which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the sulfate salt are characterized by a variety of properties and physical measurements. As well, methods of producing the sulfate salts, and using such salts to inhibit excessive tyrosine kinase activity in subjects to treat a number of diseases including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer (e.g., leukemia such as acute lymphocytic leukemia), glomerulosclerosis fibrotic diseases and inflammation, and general treatment of cell-proliferative diseases, are also discussed.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.

Abstract: The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.

Abstract: A valve actuation system with cooperating pneumatic and hydraulic control features. Compressed pneumatic fluid is generated in a pneumatic fluid supply, and flows in response to requirements between a predetermined command signal and an existing position of a working fluid valve. Hydraulic fluid is pressurized by a pump, and stored within the system by an accumulator. A servo valve comprising a pneumatic fluid flow path and a hydraulic fluid flow path is included to facilitate the flow of hydraulic fluid through the servo valve hydraulic fluid path and a downstream actuator for the working fluid valve in proportion to changes in pneumatic fluid flow through the servo valve pneumatic fluid flow path. A saturated fluid feedback circuit is included to shut off the flow of pneumatic and hydraulic fluid during select periods, such periods typically coincident with static conditions within the actuator of the working fluid valve, thereby reducing pump duty cycle.

Abstract: A valve actuation system with cooperating pneumatic and hydraulic control features. Compressed pneumatic fluid is generated in a pneumatic fluid supply, and flows in response to requirements between a predetermined command signal and an existing position of a working fluid valve. Hydraulic fluid is pressurized by a pump, and stored within the system by an accumulator. A servo valve comprising a pneumatic fluid flow path and a hydraulic fluid flow path is included to facilitate the flow of hydraulic fluid through the servo valve hydraulic fluid path and a downstream actuator for the working fluid valve in proportion to changes in pneumatic fluid flow through the servo valve pneumatic fluid flow path. A saturated fluid feedback circuit is included to shut off the flow of pneumatic and hydraulic fluid during select periods, such periods typically coincident with static conditions within the actuator of the working fluid valve, thereby reducing pump duty cycle.

Abstract: An apparatus for heating a module mounted on a card includes a heating chamber adapted to receive the card and module, a nozzle adapted to surround the module and provide a flow of heated gas thereover, and a heated support surface for heating a bottom surface of a card immediately underlying the module. The method of removing and replacing a module on a card includes preheating the card and module prior to heating the contact sites to a solder reflow temperature and also preheating a card and a replacement module to an equilibrium temperature prior to increasing the temperature of the contact sites to the reflow temperature. The apparatus and method embodying the present invention effectively addresses the problem of providing a faster heating cycle, and a more even temperature distribution across the contact sites of the module and card.

Abstract: A foot operated door stop adapted to be positioned in a floor opening adjacent the door so as to effectively limit its degree of opening as a safety and anti-burglar means. This door stopper is in the form of inner and outer telescopically mounted cylindrical members. The inner cylinder is spring urged to an extended position wherein such member projects upwardly from the floor in a door blocking position. The inner member is guided by specific means at the upper and lower ends of the outer member and a particular detent assembly is mounted in such inner member so as to present the means by which the inner member may be held in its retracted or non-operative position. The inner cylinder is also adapted to freely rotate with respect to the outer cylinder.