Abstract: The devices, methods and systems are described for providing controlled amounts of gas, gas pressure and vacuum to microfluidic devices the culturing of cells under flow conditions. The devices, methods, and systems contemplated here may also be used to control the environment surrounding the microfluidic devices; offer user control over experiments comprising microfluidic devices, such as the ability to directly or remotely control experiment conditions; and comprise information aggregation and transmission, such that experimental data may be collected, stored, aggregated and transmitted to users.

Abstract: Devices, methods and systems are described for providing controlled amounts of gas, gas pressure and vacuum to microfluidic devices the culturing of cells under flow conditions.

Abstract: A system for performing a laminoplasty procedure in a spinal vertebra includes an implant and an inserter tool. The implant is configured to be placed on a previously formed lamina opening of the spinal vertebra, and is shaped and dimensioned to be placed in the lamina opening after the opening has been distracted. The inserter tool is configured to insert the implant near the lamina opening and then to distract the lamina opening so that the lamina opening is dimensioned to receive the implant and then to place the implant into the distracted lamina opening while simultaneously holding the lamina opening in a distracted state.

Abstract: A connector assembly for translateral linking of bilateral spinal fixation rods includes first and second components. The first component has an elongated body having first and second ends, and the first end of the first component is configured to connect to a first spinal fixation rod. The second component has an elongated body having first and second ends, and the first end of the second component is configured to connect to a second spinal fixation rod. The second end of the first component is configured to be slidably connected to the second end of the second component.

Abstract: A method for fusing two adjacent stacked bones includes the following. First, inserting first and second pins into first and second locations of a first surface of one of the two adjacent stacked bones, respectively. Next, inserting a dilator over each of the first and second pins to dilate tissue around the first and second pins. Next, inserting a tissue protector over the dilator and removing the dilator. Next, inserting a cannulated drill through the tissue protector over each of the first and second pins and drilling first and second openings in the first and second locations, respectively, wherein the first and second opening extend through the two adjacent stacked bones. Next, tapping threads in the first opening and inserting a first bone fusing implant in the first opening, wherein the first bone fusing implant comprises threads configured to engage the threads of the first opening.

Abstract: An improved spinous process fixation implant assembly 50 includes a spinous process fixation implant 100 and an interspinous spacer implant 200. The spinous process fixation implant 100 includes elongated first and second components 110, 120, that are arranged opposite and parallel to each other. First and second spinous processes 90a, 90b of first and second adjacent vertebrae 80a, 80b are clamped between the first and second components 110, 120, respectively, and are separated by the interspinous spacer implant 200. The interspinous spacer implant 200 may be inserted between the spinous processes of adjacent vertebrae from two different directions.

Abstract: A system for performing a laminoplasty procedure in a spinal vertebra includes an implant and an inserter tool. The implant is configured to be placed on a previously formed lamina opening of the spinal vertebra, and is shaped and dimensioned to be placed in the lamina opening after the opening has been distracted. The inserter tool is configured to insert the implant near the lamina opening and then to distract the lamina opening so that the lamina opening is dimensioned to receive the implant and then to place the implant into the distracted lamina opening while simultaneously holding the lamina opening in a distracted state.

Abstract: A method for fusing two adjacent stacked bones includes the following. First, inserting first and second pins into first and second locations of a first surface of one of the two adjacent stacked bones, respectively. Next, inserting a dilator over each of the first and second pins to dilate tissue around the first and second pins. Next, inserting a tissue protector over the dilator and removing the dilator. Next, inserting a cannulated drill through the tissue protector over each of the first and second pins and drilling first and second openings in the first and second locations, respectively, wherein the first and second opening extend through the two adjacent stacked bones. Next, tapping threads in the first opening and inserting a first bone fusing implant in the first opening, wherein the first bone fusing implant comprises threads configured to engage the threads of the first opening.

Abstract: A method for spinal rod insertion includes providing a U-shaped hook tool comprising first and second legs, and inserting the first leg into a first location of a first vertebra and then pushing the hook tool along an arc-shaped path until the first leg exits through a second location of an adjacent second vertebra. Next, providing a spinal stabilization rod and a folded flexible wire comprising first and second open ends at the front end and a closed loop end. The closed loop end is attached to a first end of the spinal stabilization rod and the first and second open ends of the folded flexible wire are inserted into an open end of the second leg of the hook, and the folded flexible wire is threaded through the U-shaped hook and the first and second open ends of the flexible wire exit through an open end of the first leg.

Abstract: A cannula assembly for providing percutaneous access in minimally invasive spinal surgeries, includes an outer cannula, a nerve probe dilator and a multistage dilator system comprising a first dilator, a second dilator, a third dilator and a fourth dilator. The outer cannula and the dilators are slidable relative to each other and are arranged sequentially so that the fourth dilator surrounds the nerve probe dilator, the third dilator slides over a surface of the fourth dilator, the second dilator slides over a surface of the third dilator, the first dilator slides over a surface of the second dilator, and the outer cannula surrounds the first dilator.

Abstract: A spinal stabilization implant assembly includes a first cervical stabilization plate comprising an elongated body having a top portion and a bottom portion, and a second cervical stabilization plate comprising an elongated body having a top portion and a bottom portion. The bottom portion of the first cervical stabilization plate is attached to a first vertebra and the top portion of the second stabilization plate is stacked end-to-end below the bottom portion of the first cervical stabilization plate and is attached to the same first vertebra. The top portion of the first cervical stabilization plate is attached to a second vertebra, and the bottom portion of the second stabilization plate is attached to a third vertebra. The second vertebra is superior to the first vertebra, and the third vertebra is inferior to the first vertebra.

Abstract: A connector assembly for translateral linking of bilateral spinal fixation rods includes first and second components. The first component has an elongated body having first and second ends, and the first end of the first component is configured to connect to a first spinal fixation rod. The second component has an elongated body having first and second ends, and the first end of the second component is configured to connect to a second spinal fixation rod. The second end of the first component is configured to be slidably connected to the second end of the second component.

Abstract: A spinal screw assembly includes a bone-anchoring member, a washer, and a seat. The bone-anchoring member includes a main shaft, a washer head, and a spherical head. The spherical head extends upward from the top end of the main shaft and the washer head extends laterally from a location of the main shaft between the main shaft's top end and bottom end. The washer is polyaxially rotatable and positionable around the washer head and is configured to be placed at a first angle relative to the main shaft. The seat is polyaxially rotatable and positionable around the spherical head independent from the washer and is configured to be placed at a second angle relative to the main shaft, wherein the second angle is independent from the first angle.

Abstract: An implantable cervical plate assembly includes a cervical plate, one or more bone fasteners and a driver tool. The cervical plate comprises an elongated asymmetric body having one or more through-openings extending from the front surface to the back surface of the elongated asymmetric body. The one or more bone fasteners are configured to be inserted through the one or more through-openings, respectively. The bone fasteners comprise a threaded main body and a head that includes one or more flexible structures configured to be flexed and inserted into a groove and then unflex and remain captured within the groove. The driver tool includes an elongated shaft, a handle and a bone fastener-engaging. The bone fastener-engaging component comprises one or more structures that complement and engage at least one of grooves and lobes of the bone fastener opening.

Abstract: A method for spinal rod insertion includes providing a U-shaped hook tool comprising first and second legs, and inserting the first leg into a first location of a first vertebra and then pushing the hook tool along an arc-shaped path until the first leg exits through a second location of an adjacent second vertebra. Next, providing a spinal stabilization rod and a folded flexible wire comprising first and second open ends at the front end and a closed loop end. The closed loop end is attached to a first end of the spinal stabilization rod and the first and second open ends of the folded flexible wire are inserted into an open end of the second leg of the hook, and the folded flexible wire is threaded through the U-shaped hook and the first and second open ends of the flexible wire exit through an open end of the first leg.

Abstract: A cannula assembly for providing percutaneous access in minimally invasive spinal surgeries, includes an outer cannula, a nerve probe dilator and a multistage dilator system comprising a first dilator, a second dilator, a third dilator and a fourth dilator. The outer cannula and the dilators are slidable relative to each other and are arranged sequentially so that the fourth dilator surrounds the nerve probe dilator, the third dilator slides over a surface of the fourth dilator, the second dilator slides over a surface of the third dilator, the first dilator slides over a surface of the second dilator, and the outer cannula surrounds the first dilator.

Abstract: An improved spinous process fixation implant assembly 50 includes a spinous process fixation implant 100 and an interspinous spacer implant 200. The spinous process fixation implant 100 includes elongated first and second components 110, 120, that are arranged opposite and parallel to each other. First and second spinous processes 90a, 90b of first and second adjacent vertebrae 80a, 80b are clamped between the first and second components 110, 120, respectively, and are separated by the interspinous spacer implant 200. The interspinous spacer implant 200 may be inserted between the spinous processes of adjacent vertebrae from two different directions.

Abstract: A spinal fixation and fusion assembly includes a bone anchoring member, a cylindrical rod and a cap. The bone anchoring member comprises an elongated body that is made entirely of bone type material. The elongated body includes a main shaft, a conical shaped distal end, a flared out proximal end, and a through-opening extending along an axis from the proximal end to the distal end. The cylindrical rod is shaped and dimensioned to be received within the through-opening and is made entirely of metal. The cap is made entirely of metal and is attached to a proximal end of the cylindrical rod.

Abstract: A spinal screw assembly includes a bone-anchoring member, a washer, and a seat. The bone-anchoring member includes a main shaft, a washer head, and a spherical head. The spherical head extends upward from the top end of the main shaft and the washer head extends laterally from a location of the main shaft between the main shaft's top end and bottom end. The washer is polyaxially rotatable and positionable around the washer head and is configured to be placed at a first angle relative to the main shaft. The seat is polyaxially rotatable and positionable around the spherical head independent from the washer and is configured to be placed at a second angle relative to the main shaft, wherein the second angle is independent from the first angle.